PMID- 36693879
OWN - NLM
STAT- MEDLINE
DCOM- 20230126
LR  - 20230316
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Jan 24
TI  - Experimental validation of proton boron capture therapy for glioma cells.
PG  - 1341
LID - 10.1038/s41598-023-28428-z [doi]
LID - 1341
AB  - Proton boron capture therapy (PBCT) has emerged from particle acceleration 
      research for enhancing the biological effectiveness of proton therapy. The 
      mechanism responsible for the dose increase was supposed to be related to 
      proton-boron fusion reactions ((11)B + p --> 3alpha + 8.7 MeV). There has been some 
      experimental evidence that the biological efficiency of protons is significantly 
      higher for boron-11-containing prostate or breast cancer cells. The aim of this 
      study was to evaluate the sensitizing potential of sodium borocaptate (BSH) under 
      proton irradiation at the Bragg peak of cultured glioma cells. To address this 
      problem, cells of two glioma lines were preincubated with 80 or 160 ppm boron-11, 
      irradiated both at the middle of 200 MeV beam Spread-Out Bragg Peak (SOBP) and at 
      the distal end of the 89.7 MeV beam SOBP and assessed for the viability, as well 
      as their ability to form colonies. Our results clearly show that BSH provides for 
      only a slight, if any, enhancement of the effect of proton radiation on the 
      glioma cells in vitro. In addition, we repeated the experiments using the Du145 
      prostate cancer cell line, for which an increase in the biological efficiency of 
      proton irradiation in the presence of sodium borocaptate was demonstrated 
      previously. The data presented add new argument against the efficiency of proton 
      boron capture therapy when based solely on direct dose-enhancement effect by the 
      proton capture nuclear reaction, underlining the need to investigate the indirect 
      effects of the secondary alpha irradiation depending on the state and treatment 
      conditions of the irradiated tissue.
CI  - (c) 2023. The Author(s).
FAU - Shtam, Tatiana
AU  - Shtam T
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300. Shtam_TA@pnpi.nrcki.ru.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova Pl. 1, 
      Moscow, Russian Federation, 123182. Shtam_TA@pnpi.nrcki.ru.
AD  - Institute of Cytology of Russian Academy of Sciences, St. Petersburg, Russian 
      Federation. Shtam_TA@pnpi.nrcki.ru.
FAU - Burdakov, Vladimir
AU  - Burdakov V
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova Pl. 1, 
      Moscow, Russian Federation, 123182.
FAU - Garina, Alina
AU  - Garina A
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova Pl. 1, 
      Moscow, Russian Federation, 123182.
AD  - Peter the Great St.Petersburg Polytechnic University, Politehnicheskaya 29, St. 
      Petersburg, Russian Federation.
FAU - Garaeva, Luiza
AU  - Garaeva L
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova Pl. 1, 
      Moscow, Russian Federation, 123182.
AD  - Peter the Great St.Petersburg Polytechnic University, Politehnicheskaya 29, St. 
      Petersburg, Russian Federation.
FAU - Tran, Nhan Hau
AU  - Tran NH
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
AD  - Peter the Great St.Petersburg Polytechnic University, Politehnicheskaya 29, St. 
      Petersburg, Russian Federation.
FAU - Volnitskiy, Andrey
AU  - Volnitskiy A
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova Pl. 1, 
      Moscow, Russian Federation, 123182.
FAU - Kuus, Eva
AU  - Kuus E
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
AD  - Peter the Great St.Petersburg Polytechnic University, Politehnicheskaya 29, St. 
      Petersburg, Russian Federation.
AD  - Proton Therapy Center MIBS, St. Petersburg, Russian Federation.
FAU - Amerkanov, Dmitry
AU  - Amerkanov D
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova Pl. 1, 
      Moscow, Russian Federation, 123182.
FAU - Pack, Fedor
AU  - Pack F
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova Pl. 1, 
      Moscow, Russian Federation, 123182.
FAU - Andreev, Georgy
AU  - Andreev G
AD  - Proton Therapy Center MIBS, St. Petersburg, Russian Federation.
FAU - Lubinskiy, Andrey
AU  - Lubinskiy A
AD  - Proton Therapy Center MIBS, St. Petersburg, Russian Federation.
FAU - Shabalin, Konstantin
AU  - Shabalin K
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova Pl. 1, 
      Moscow, Russian Federation, 123182.
FAU - Verlov, Nicolay
AU  - Verlov N
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova Pl. 1, 
      Moscow, Russian Federation, 123182.
FAU - Ivanov, Evgeniy
AU  - Ivanov E
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
FAU - Ezhov, Victor
AU  - Ezhov V
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
FAU - Lebedev, Dmitry
AU  - Lebedev D
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova Pl. 1, 
      Moscow, Russian Federation, 123182.
FAU - Konevega, Andrey L
AU  - Konevega AL
AD  - Petersburg Nuclear Physics Institute Named By B.P. Konstantinov of National 
      Research Centre "Kurchatov Institute", Leningradskaya Oblast, Mkr. Orlova Roshcha 
      1, Gatchina, Russian Federation, 188300. konevega_al@pnpi.nrcki.ru.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova Pl. 1, 
      Moscow, Russian Federation, 123182. konevega_al@pnpi.nrcki.ru.
AD  - Peter the Great St.Petersburg Polytechnic University, Politehnicheskaya 29, St. 
      Petersburg, Russian Federation. konevega_al@pnpi.nrcki.ru.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230124
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Protons)
RN  - N9E3X5056Q (Boron)
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Male
MH  - Humans
MH  - Protons
MH  - Boron/pharmacology
MH  - *Proton Therapy
MH  - *Glioma/radiotherapy/metabolism
MH  - Sodium
PMC - PMC9873635
COIS- The authors declare no competing interests.
EDAT- 2023/01/25 06:00
MHDA- 2023/01/27 06:00
PMCR- 2023/01/24
CRDT- 2023/01/24 23:16
PHST- 2022/05/25 00:00 [received]
PHST- 2023/01/18 00:00 [accepted]
PHST- 2023/01/24 23:16 [entrez]
PHST- 2023/01/25 06:00 [pubmed]
PHST- 2023/01/27 06:00 [medline]
PHST- 2023/01/24 00:00 [pmc-release]
AID - 10.1038/s41598-023-28428-z [pii]
AID - 28428 [pii]
AID - 10.1038/s41598-023-28428-z [doi]
PST - epublish
SO  - Sci Rep. 2023 Jan 24;13(1):1341. doi: 10.1038/s41598-023-28428-z.