PMID- 36694808 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230201 IS - 2472-1972 (Electronic) IS - 2472-1972 (Linking) VI - 7 IP - 3 DP - 2023 Jan 6 TI - Combined Hypophysitis and Type 1 Diabetes Mellitus Related to Immune Checkpoint Inhibitors. PG - bvad002 LID - 10.1210/jendso/bvad002 [doi] LID - bvad002 AB - CONTEXT: The occurrence of multiple endocrinopathies due to immune checkpoint inhibitors (ICIs) is a relatively common adverse event. However, the occurrence of a combination of hypophysitis and type 1 diabetes mellitus (T1DM) is extremely rare, and its clinical features are unclear. OBJECTIVE: We comparatively analyzed the clinical features of this combination and each individual ICI-induced endocrinopathy. METHODS: We reported 3 cases that we encountered and reviewed previously reported cases of patients with combined hypophysitis and T1DM due to ICIs. RESULTS: Anti-programmed cell death-1 (anti-PD-1) antibodies were prescribed to all 3 cases. The duration from ICI initiation to the onset of endocrine disease was 12 to 48 weeks. Several human leukocyte antigen (HLA) haplotypes that have disease susceptibility to hypophysitis were detected in all 3 patients. With the 17 previously reported cases, combined endocrinopathies were more common in men (85%). The onset age was in the 60s for both combined and single endocrinopathies. Anti-PD-1 antibodies were used in most of the cases (90%). The time from ICI initiation to the onset of endocrinopathies was 24 (8-76) weeks for hypophysitis and 32 (8-76) weeks for T1DM in patients with combined endocrinopathies, which was not significantly different from that for each single endocrinopathy. CONCLUSION: We presented 3 cases of patients with combined endocrinopathies of hypophysitis and T1DM that may have been caused by anti-PD-1 antibodies. There was no difference in the time from ICI initiation to the onset of endocrinopathies between combined and single endocrinopathies. Further case accumulation and pathogenic investigations are required. CI - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Fujita, Yasunori AU - Fujita Y AD - Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Kamitani, Fumika AU - Kamitani F AD - Department of Diabetes and Endocrinology, Nara Medical University, Nara, Japan. FAU - Yamamoto, Masaaki AU - Yamamoto M AD - Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Fukuoka, Hidenori AU - Fukuoka H AUID- ORCID: 0000-0001-9255-653X AD - Division of Diabetes and Endocrinology, Kobe University Hospital, Kobe, Japan. FAU - Hirota, Yushi AU - Hirota Y AD - Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Nishiyama, Nobuharu AU - Nishiyama N AD - Division of Diabetes and Endocrinology, Kobe University Hospital, Kobe, Japan. FAU - Goda, Naho AU - Goda N AD - Division of Diabetes and Endocrinology, Kobe University Hospital, Kobe, Japan. FAU - Okada, Yuko AU - Okada Y AD - Division of Diabetes and Endocrinology, Kobe University Hospital, Kobe, Japan. FAU - Inaba, Yuiko AU - Inaba Y AD - Division of Diabetes and Endocrinology, Kobe University Hospital, Kobe, Japan. FAU - Nakajima, Hiroki AU - Nakajima H AD - Department of Diabetes and Endocrinology, Nara Medical University, Nara, Japan. FAU - Kurematsu, Yukako AU - Kurematsu Y AD - Department of Diabetes and Endocrinology, Nara Medical University, Nara, Japan. FAU - Kanie, Keitaro AU - Kanie K AUID- ORCID: 0000-0002-9004-9857 AD - Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Shichi, Hiroki AU - Shichi H AD - Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Urai, Shin AU - Urai S AD - Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Suzuki, Masaki AU - Suzuki M AD - Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Yamamoto, Naoki AU - Yamamoto N AD - Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Bando, Hironori AU - Bando H AUID- ORCID: 0000-0002-7421-2714 AD - Division of Diabetes and Endocrinology, Kobe University Hospital, Kobe, Japan. AD - Division of Development of Advanced Therapy for Metabolic Diseases, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Iguchi, Genzo AU - Iguchi G AD - Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan. AD - Medical Center for Student Health, Kobe University, Kobe, Japan. AD - Division of Biosignal Pathophysiology, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Suto, Hirotaka AU - Suto H AD - Division of Medical Oncology and Hematology, Kobe University Graduate School of Medicine, Kobe, Japan. AD - Department of Medical Oncology and Hematology, Cancer Center, Kobe University Hospital, Kobe, Japan. FAU - Funakoshi, Yohei AU - Funakoshi Y AD - Division of Medical Oncology and Hematology, Kobe University Graduate School of Medicine, Kobe, Japan. AD - Department of Medical Oncology and Hematology, Cancer Center, Kobe University Hospital, Kobe, Japan. FAU - Kiyota, Naomi AU - Kiyota N AD - Division of Medical Oncology and Hematology, Kobe University Graduate School of Medicine, Kobe, Japan. AD - Department of Medical Oncology and Hematology, Cancer Center, Kobe University Hospital, Kobe, Japan. FAU - Takahashi, Yutaka AU - Takahashi Y AD - Department of Diabetes and Endocrinology, Nara Medical University, Nara, Japan. FAU - Ogawa, Wataru AU - Ogawa W AD - Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan. LA - eng PT - Journal Article DEP - 20230106 PL - United States TA - J Endocr Soc JT - Journal of the Endocrine Society JID - 101697997 PMC - PMC9856268 OTO - NOTNLM OT - HLA haplotype OT - combined endocrinopathies OT - diabetes mellitus OT - hypophysitis OT - immune checkpoint inhibitors EDAT- 2023/01/26 06:00 MHDA- 2023/01/26 06:01 PMCR- 2023/01/06 CRDT- 2023/01/25 01:48 PHST- 2022/09/30 00:00 [received] PHST- 2023/01/25 01:48 [entrez] PHST- 2023/01/26 06:00 [pubmed] PHST- 2023/01/26 06:01 [medline] PHST- 2023/01/06 00:00 [pmc-release] AID - bvad002 [pii] AID - 10.1210/jendso/bvad002 [doi] PST - epublish SO - J Endocr Soc. 2023 Jan 6;7(3):bvad002. doi: 10.1210/jendso/bvad002. eCollection 2023 Jan 6.