PMID- 36694955
OWN - NLM
STAT- MEDLINE
DCOM- 20230505
LR  - 20230505
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 64
IP  - 5
DP  - 2023 May
TI  - Diagnostic outcome and safety of plugged liver biopsy in high-risk patients: a 
      systematic review and meta-analysis.
PG  - 1775-1782
LID - 10.1177/02841851231151513 [doi]
AB  - BACKGROUND: Percutaneous liver biopsy is the gold standard test for the 
      assessment of liver disease. In patients with coagulopathy, ascites, 
      post-transplantation, and hypervascular tumors, biopsy is associated with 
      increased risk of adverse events (AEs). Transjugular liver biopsy (TJLB) is 
      recommended in these conditions but is expensive and unavailable at many centers. 
      Plugged liver biopsy (PLB) provides an alternate diagnostic modality in these 
      high-risk cases. PURPOSE: To analyze the pooled diagnostic outcome and safety of 
      PLB in high-risk cases. MATERIAL AND METHODS: A literature search of various 
      databases from January 1990 to July 2022 was conducted for studies evaluating the 
      outcome of PLB in high-risk cases. The primary outcomes were pooled sample 
      adequacy and AEs. Pooled event rates across studies were expressed with summative 
      statistics. RESULTS: A total of 17 studies (2329 patients) were included in the 
      meta-analysis. The pooled proportion of sample adequacy was 98.9% (95% confidence 
      interval [CI]=98.2-99.6). Severe AEs, major bleeding, and minor AEs were seen in 
      0.7% (95% CI=0.1-1.3), 0.4% (95% CI=0.1-0.8), and 11.5% (95% CI=2.4-20.6) of the 
      patients. There was only one reported mortality, giving a pooled incidence of 
      0.0002% (95% CI=0.0-0.0038). Compared to TJLB (5 studies, n = 336), there was no 
      difference in either sample adequacy (odds ratio [OR]=2.34, 95% CI=0.83-6.58) or 
      risk of serious AEs (OR=0.47, 95% CI=0.173-1.31). CONCLUSION: PLB can be safely 
      performed on patients with coagulopathy and/or ascites with high sample adequacy 
      rates and low incidence of AEs and mortality.
FAU - Giri, Suprabhat
AU  - Giri S
AUID- ORCID: 0000-0002-9626-5243
AD  - Department of Gastroenterology, Nizam's Institute of Medical Sciences, Hyderabad, 
      India.
FAU - Agrawal, Dhiraj
AU  - Agrawal D
AD  - Department of Gastroenterology, PACE Hospital, Hyderabad, India.
FAU - Gopan, Amrit
AU  - Gopan A
AD  - Department of Gastroenterology, Seth GS Medical College and KEM Hospital, Mumbai, 
      India. RINGGOLD: 29549
FAU - Varghese, Jijo
AU  - Varghese J
AD  - Department of Gastroenterology, KM Cherian Institute of Medical Sciences, 
      Kallissery, India.
FAU - Tripathy, Taraprasad
AU  - Tripathy T
AUID- ORCID: 0000-0003-3763-9089
AD  - Department of Radiodiagnosis, All India Institute of Medical Sciences, 
      Bhubaneswar, India.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20230124
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
SB  - IM
MH  - Humans
MH  - *Ascites
MH  - Liver/pathology
MH  - Biopsy
MH  - *Liver Diseases
MH  - Biopsy, Needle
OTO - NOTNLM
OT  - Liver biopsy
OT  - cirrhosis
OT  - coil
OT  - gel foam
OT  - meta-analysis
OT  - transjugular liver biopsy
EDAT- 2023/01/26 06:00
MHDA- 2023/05/05 06:42
CRDT- 2023/01/25 02:22
PHST- 2023/05/05 06:42 [medline]
PHST- 2023/01/26 06:00 [pubmed]
PHST- 2023/01/25 02:22 [entrez]
AID - 10.1177/02841851231151513 [doi]
PST - ppublish
SO  - Acta Radiol. 2023 May;64(5):1775-1782. doi: 10.1177/02841851231151513. Epub 2023 
      Jan 24.