PMID- 36695463
OWN - NLM
STAT- MEDLINE
DCOM- 20230126
LR  - 20230505
IS  - 1560-7917 (Electronic)
IS  - 1025-496X (Print)
IS  - 1025-496X (Linking)
VI  - 27
IP  - 48
DP  - 2022 Dec
TI  - Nosocomial outbreak of vancomycin-resistant Enterococcus faecium (VRE) ST796, 
      Switzerland, 2017 to 2020.
LID - 10.2807/1560-7917.ES.2022.27.48.2200285 [doi]
LID - 2200285
AB  - A large clonal outbreak caused by vancomycin-resistant Enterococcus faecium (VRE) 
      affected the Bern University Hospital group from the end of December 2017 until 
      July 2020. We describe the characteristics of the outbreak and the bundle of 
      infection prevention and control (IPC) measures implemented. The outbreak was 
      first recognised when two concomitant cases of VRE bloodstream infection were 
      identified on the oncology ward. During 32 months, 518 patients in the 1,300-bed 
      hospital group were identified as vanB VRE carriers. Eighteen (3.5%) patients 
      developed an invasive infection, of whom seven had bacteraemia. In 2018, a subset 
      of 328 isolates were analysed by whole genome sequencing, 312 of which were 
      identified as sequence type (ST) 796. The initial IPC measures were implemented 
      with a focus on the affected wards. However, in June 2018, ST796 caused another 
      increase in cases, and the management strategy was intensified and escalated to a 
      hospital-wide level. The clinical impact of this large nosocomial VRE outbreak 
      with the emergent clone ST796 was modest. A hospital-wide approach with a 
      multimodal IPC bundle was successful against this highly transmissible strain.
FAU - Piezzi, Vanja
AU  - Piezzi V
AD  - Department of Infectious Diseases, University Hospital Bern, University of Bern, 
      Bern, Switzerland.
FAU - Wassilew, Nasstasja
AU  - Wassilew N
AD  - Department of Infectious Diseases, University Hospital Bern, University of Bern, 
      Bern, Switzerland.
FAU - Atkinson, Andrew
AU  - Atkinson A
AD  - Department of Infectious Diseases, University Hospital Bern, University of Bern, 
      Bern, Switzerland.
FAU - D'Incau, Stephanie
AU  - D'Incau S
AD  - Department of Infectious Diseases, Lucerne Cantonal Hospital, Lucerne, 
      Switzerland.
FAU - Kaspar, Tanja
AU  - Kaspar T
AD  - Department of Infectious Diseases, University Hospital Bern, University of Bern, 
      Bern, Switzerland.
FAU - Seth-Smith, Helena Mb
AU  - Seth-Smith HM
AD  - Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
AD  - Division of Clinical Bacteriology and Mycology, University Hospital Basel, Basel, 
      Switzerland and Applied Microbiology Research, Department of Biomedicine, 
      University of Basel, Basel, Switzerland.
FAU - Casanova, Carlo
AU  - Casanova C
AD  - Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
FAU - Bittel, Pascal
AU  - Bittel P
AD  - Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
FAU - Jent, Philipp
AU  - Jent P
AD  - Department of Infectious Diseases, University Hospital Bern, University of Bern, 
      Bern, Switzerland.
FAU - Sommerstein, Rami
AU  - Sommerstein R
AD  - Department Health Sciences and Medicine, Clinic St. Anna, University of Lucerne, 
      Lucerne, Switzerland.
AD  - Department of Infectious Diseases, University Hospital Bern, University of Bern, 
      Bern, Switzerland.
FAU - Buetti, Niccolo
AU  - Buetti N
AD  - INSERM, IAME, Universite Paris-Cite, Paris, France.
AD  - Infection Control Programme, University of Geneva Hospitals and Faculty of 
      Medicine, Geneva, Switzerland.
FAU - Marschall, Jonas
AU  - Marschall J
AD  - Division of Infectious Diseases, Department of Internal Medicine, Washington 
      University School of Medicine, St. Louis, MO, United States.
AD  - Department of Infectious Diseases, University Hospital Bern, University of Bern, 
      Bern, Switzerland.
LA  - eng
PT  - Journal Article
PL  - Sweden
TA  - Euro Surveill
JT  - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European 
      communicable disease bulletin
JID - 100887452
RN  - 6Q205EH1VU (Vancomycin)
SB  - IM
MH  - Humans
MH  - Vancomycin
MH  - *Enterococcus faecium/genetics
MH  - *Cross Infection/epidemiology
MH  - Switzerland/epidemiology
MH  - *Vancomycin-Resistant Enterococci/genetics
MH  - Disease Outbreaks
MH  - Hospitals, University
MH  - *Gram-Positive Bacterial Infections/epidemiology
PMC - PMC9716646
OTO - NOTNLM
OT  - VRE
OT  - Vancomycin resistant Enterococcus faecium
OT  - Whole genome sequencing
OT  - antibiotic resistance
OT  - infection prevention and control
OT  - nosocomial outbreak
OT  - outbreak management
COIS- Conflict of interest: None declared.
EDAT- 2023/01/26 06:00
MHDA- 2023/01/27 06:00
PMCR- 2022/12/01
CRDT- 2023/01/25 07:13
PHST- 2023/01/25 07:13 [entrez]
PHST- 2023/01/26 06:00 [pubmed]
PHST- 2023/01/27 06:00 [medline]
PHST- 2022/12/01 00:00 [pmc-release]
AID - 2200285 [pii]
AID - 10.2807/1560-7917.ES.2022.27.48.2200285 [doi]
PST - ppublish
SO  - Euro Surveill. 2022 Dec;27(48):2200285. doi: 
      10.2807/1560-7917.ES.2022.27.48.2200285.