PMID- 36695699
OWN - NLM
STAT- MEDLINE
DCOM- 20230314
LR  - 20230323
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 23
IP  - 3
DP  - 2023 Mar
TI  - Prevalence and progression of intraductal papillary mucinous neoplasms of the 
      pancreas in solid organ transplant recipients: A systematic review.
PG  - 429-436
LID - S1600-6135(22)29296-X [pii]
LID - 10.1016/j.ajt.2022.11.024 [doi]
AB  - Solid organ transplantation (SOT) recipients are known to carry an increased risk 
      of malignancy because of long-term immunosuppression. However, the progression of 
      intraductal papillary mucinous neoplasm of the pancreas (IPMN) in this population 
      remains unclear. We performed a systematic review by searching PubMed, Embase, 
      Scopus, and Google Scholar. All studies containing IPMNs in solid organ 
      transplantation recipients were screened. We included 11 studies in our final 
      analysis, totaling 274 patients with IPMNs of the 8213 SOT recipients. The 
      prevalence from 8 studies was 4.7% (95% CI 2.4%-7.7%) in a random-effects model 
      with median study periods of 24 to 220 months. The median rate for all 
      progressions from 10 studies was 20% (range, 0%-88%) within 13 to 41 months of 
      the median follow-up time. By utilizing the results of 3 case-control studies, 
      the relative risk from a random-effects model for progression (worrisome features 
      and high-risk stigmata) of IPMNs was 0.39 (95% CI 0.12-1.31). No adenocarcinoma 
      derived from IPMN was reported in the included studies. Overall, this study 
      indicates that the progression of pretransplant IPMN does not increase 
      drastically compared with the general nontransplant population. However, 
      considering the limited literature, further studies are required for 
      confirmation.
CI  - Copyright (c) 2022 American Society of Transplantation & American Society of 
      Transplant Surgeons. Published by Elsevier Inc. All rights reserved.
FAU - Sugawara, Toshitaka
AU  - Sugawara T
AD  - Division of Surgical Oncology, Department of Surgery, University of Colorado 
      School of Medicine, Aurora, Colorado, USA; Department of Hepatobiliary and 
      Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental 
      University, Tokyo, Japan.
FAU - Franco, Salvador Rodriguez
AU  - Franco SR
AD  - Division of Surgical Oncology, Department of Surgery, University of Colorado 
      School of Medicine, Aurora, Colorado, USA.
FAU - Ishida, Jun
AU  - Ishida J
AD  - Division of Surgical Oncology, Department of Surgery, University of Colorado 
      School of Medicine, Aurora, Colorado, USA.
FAU - Kalra, Avash
AU  - Kalra A
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, University 
      of Colorado School of Medicine, Aurora, Colorado, USA.
FAU - Saben, Jessica L
AU  - Saben JL
AD  - Division of Transplant Surgery, Department of Surgery, University of Colorado 
      School of Medicine, Aurora, Colorado, USA.
FAU - Galvez, Karla Navarrete
AU  - Galvez KN
AD  - Division of Surgical Oncology, Department of Surgery, University of Colorado 
      School of Medicine, Aurora, Colorado, USA.
FAU - Kirsch, Michael J
AU  - Kirsch MJ
AD  - Department of Surgery, University of Colorado School of Medicine, Aurora, 
      Colorado, USA.
FAU - Al-Musawi, Mohammed H
AU  - Al-Musawi MH
AD  - Department of Surgery, University of Colorado School of Medicine, Aurora, 
      Colorado, USA.
FAU - Kaplan, Bruce
AU  - Kaplan B
AD  - Division of Transplant Surgery, Department of Surgery, University of Colorado 
      School of Medicine, Aurora, Colorado, USA.
FAU - Pomfret, Elizabeth A
AU  - Pomfret EA
AD  - Division of Transplant Surgery, Department of Surgery, University of Colorado 
      School of Medicine, Aurora, Colorado, USA.
FAU - Schulick, Richard D
AU  - Schulick RD
AD  - Department of Surgery, University of Colorado School of Medicine, Aurora, 
      Colorado, USA; University of Colorado Cancer Center, Aurora, Colorado, USA.
FAU - Del Chiaro, Marco
AU  - Del Chiaro M
AD  - Division of Surgical Oncology, Department of Surgery, University of Colorado 
      School of Medicine, Aurora, Colorado, USA; University of Colorado Cancer Center, 
      Aurora, Colorado, USA. Electronic address: marco.delchiaro@cuanschutz.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20230112
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Humans
MH  - *Pancreatic Intraductal Neoplasms
MH  - *Carcinoma, Pancreatic Ductal/pathology
MH  - Prevalence
MH  - Retrospective Studies
MH  - *Adenocarcinoma, Mucinous/pathology
MH  - *Pancreatic Neoplasms/pathology
MH  - Pancreas
MH  - *Organ Transplantation
OTO - NOTNLM
OT  - immunosuppression
OT  - intraductal papillary mucinous neoplasm (IPMN)
OT  - prevalence
OT  - progression
OT  - recipient
OT  - solid organ transplant
OT  - systematic review
EDAT- 2023/01/26 06:00
MHDA- 2023/03/15 06:00
CRDT- 2023/01/25 09:42
PHST- 2022/08/08 00:00 [received]
PHST- 2022/11/17 00:00 [revised]
PHST- 2022/11/27 00:00 [accepted]
PHST- 2023/01/26 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
PHST- 2023/01/25 09:42 [entrez]
AID - S1600-6135(22)29296-X [pii]
AID - 10.1016/j.ajt.2022.11.024 [doi]
PST - ppublish
SO  - Am J Transplant. 2023 Mar;23(3):429-436. doi: 10.1016/j.ajt.2022.11.024. Epub 
      2023 Jan 12.