PMID- 36695738
OWN - NLM
STAT- MEDLINE
DCOM- 20230309
LR  - 20230315
IS  - 1530-6992 (Electronic)
IS  - 1530-6984 (Linking)
VI  - 23
IP  - 5
DP  - 2023 Mar 8
TI  - One-Dimensional Rod-like Tobacco Mosaic Virus Promotes Macrophage Polarization 
      for a Tumor-Suppressive Microenvironment.
PG  - 2056-2064
LID - 10.1021/acs.nanolett.2c03809 [doi]
AB  - The phenotype of tumor-associated macrophages plays an important role in their 
      function of regulating the tumor immune microenvironment. The M1-phenotype 
      macrophages display tumor-killing and immune activating functions. Here we show 
      that the tobacco mosaic virus (TMV), a rod-like plant virus, can polarize 
      macrophages to an M1 phenotype and shape a tumor-suppressive microenvironment. 
      RAW 264.7 cells and bone marrow derived-macrophages (BMDMs) can recognize TMV via 
      Toll-like receptor-4, and then the MAPK and NF-kappaB signaling pathways are 
      activated, leading to the production of pro-inflammatory factors. Furthermore, 
      the in vivo assessments on a subcutaneous co-injection tumor model show that the 
      TMV-polarized BMDMs shape a tumor-suppressive microenvironment, resulting in 
      remarkable delay of 4T1 tumor growth. Another in vivo assessment on an 
      established tumor model indicates the high tumor-metastasis-inhibiting capacity 
      of TMV-polarized BMDMs. This work suggests a role for this plant virus in 
      macrophage-mediated therapeutic approaches and provides a strategy for tumor 
      immunotherapy.
FAU - Ou, Jinzhao
AU  - Ou J
AD  - Key Laboratory of Photochemical Conversion and Optoelectronic Materials, 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 
      Zhongguancun East Road, Beijing 100190, P.R. China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
FAU - Zhu, Meng
AU  - Zhu M
AUID- ORCID: 0000-0001-6722-0487
AD  - Key Laboratory of Photochemical Conversion and Optoelectronic Materials, 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 
      Zhongguancun East Road, Beijing 100190, P.R. China.
FAU - Ju, Xiaoyan
AU  - Ju X
AD  - Key Laboratory of Photochemical Conversion and Optoelectronic Materials, 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 
      Zhongguancun East Road, Beijing 100190, P.R. China.
FAU - Xu, Dandan
AU  - Xu D
AD  - Key Laboratory of Photochemical Conversion and Optoelectronic Materials, 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 
      Zhongguancun East Road, Beijing 100190, P.R. China.
FAU - Lu, Guojun
AU  - Lu G
AD  - Key Laboratory of Photochemical Conversion and Optoelectronic Materials, 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 
      Zhongguancun East Road, Beijing 100190, P.R. China.
FAU - Li, Kejia
AU  - Li K
AD  - Key Laboratory of Photochemical Conversion and Optoelectronic Materials, 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 
      Zhongguancun East Road, Beijing 100190, P.R. China.
FAU - Jiang, Wei
AU  - Jiang W
AD  - Key Laboratory of Photochemical Conversion and Optoelectronic Materials, 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 
      Zhongguancun East Road, Beijing 100190, P.R. China.
FAU - Wan, Chenxiao
AU  - Wan C
AD  - Key Laboratory of Photochemical Conversion and Optoelectronic Materials, 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 
      Zhongguancun East Road, Beijing 100190, P.R. China.
FAU - Zhao, Yuexia
AU  - Zhao Y
AD  - Biochemical Engineering College, Beijing Union University, No. 97, North Fourth 
      Ring East Road, Beijing 100023, P.R. China.
FAU - Han, Yongping
AU  - Han Y
AD  - Biochemical Engineering College, Beijing Union University, No. 97, North Fourth 
      Ring East Road, Beijing 100023, P.R. China.
FAU - Tian, Ye
AU  - Tian Y
AUID- ORCID: 0000-0002-4607-2785
AD  - Key Laboratory of Photochemical Conversion and Optoelectronic Materials, 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 
      Zhongguancun East Road, Beijing 100190, P.R. China.
FAU - Niu, Zhongwei
AU  - Niu Z
AUID- ORCID: 0000-0002-6119-3227
AD  - Key Laboratory of Photochemical Conversion and Optoelectronic Materials, 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 
      Zhongguancun East Road, Beijing 100190, P.R. China.
AD  - School of Future Technology, University of Chinese Academy of Sciences, Beijing 
      100049, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230125
PL  - United States
TA  - Nano Lett
JT  - Nano letters
JID - 101088070
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Tobacco Mosaic Virus
MH  - Macrophages
MH  - Immunotherapy
MH  - RAW 264.7 Cells
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Toll-like receptor-4
OT  - macrophage polarization
OT  - tobacco mosaic virus
OT  - tumor microenvironment
EDAT- 2023/01/26 06:00
MHDA- 2023/03/10 06:00
CRDT- 2023/01/25 10:12
PHST- 2023/01/26 06:00 [pubmed]
PHST- 2023/03/10 06:00 [medline]
PHST- 2023/01/25 10:12 [entrez]
AID - 10.1021/acs.nanolett.2c03809 [doi]
PST - ppublish
SO  - Nano Lett. 2023 Mar 8;23(5):2056-2064. doi: 10.1021/acs.nanolett.2c03809. Epub 
      2023 Jan 25.