PMID- 36695937
OWN - NLM
STAT- MEDLINE
DCOM- 20230926
LR  - 20230926
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 478
IP  - 10
DP  - 2023 Oct
TI  - Chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and 
      therapy.
PG  - 2173-2190
LID - 10.1007/s11010-022-04640-9 [doi]
AB  - Chaperone-mediated autophagy (CMA) is the selective degradation process of 
      intracellular components by lysosomes, which is required for the degradation of 
      aggregate-prone proteins and contributes to proteostasis maintenance. 
      Proteostasis is essential for normal cell function and survival, and it is 
      determined by the balance of protein synthesis and degradation. Because 
      postmitotic neurons are highly susceptible to proteostasis disruption, CMA is 
      vital for the nervous system. Since Parkinson's disease (PD) was first linked to 
      CMA dysfunction, an increasing number of studies have shown that CMA loss, as 
      seen during aging, occurs in the pathogenetic process of neurodegenerative 
      diseases. Here, we review the molecular mechanisms of CMA, as well as the 
      physiological function and regulation of this autophagy pathway. Following, we 
      highlight its potential role in neurodegenerative diseases, and the latest 
      advances and challenges in targeting CMA in therapy of neurodegenerative 
      diseases.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Liu, Yi
AU  - Liu Y
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 
      China.
FAU - Tan, Lan
AU  - Tan L
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 
      China. dr.tanlan@163.com.
FAU - Tan, Meng-Shan
AU  - Tan MS
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 
      China. tanmengshan@163.com.
LA  - eng
GR  - tsqn20161078/Taishan Scholars Program of Shandong Province/
GR  - 2021-WJZD001/Medical Science Research Guidance Plan of Qingdao/
GR  - 81971032/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Review
DEP - 20230125
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Molecular Chaperones)
SB  - IM
MH  - Humans
MH  - *Neurodegenerative Diseases/therapy/metabolism
MH  - *Chaperone-Mediated Autophagy
MH  - Molecular Chaperones/metabolism
MH  - Autophagy/physiology
MH  - *Parkinson Disease/therapy/metabolism
MH  - Lysosomes/metabolism
OTO - NOTNLM
OT  - Chaperone-mediated autophagy
OT  - LAMP2A
OT  - Mechanisms
OT  - Neurodegenerative diseases
OT  - Proteostasis
OT  - Therapy
EDAT- 2023/01/26 06:00
MHDA- 2023/09/26 13:44
CRDT- 2023/01/25 11:18
PHST- 2022/07/18 00:00 [received]
PHST- 2022/12/09 00:00 [accepted]
PHST- 2023/09/26 13:44 [medline]
PHST- 2023/01/26 06:00 [pubmed]
PHST- 2023/01/25 11:18 [entrez]
AID - 10.1007/s11010-022-04640-9 [pii]
AID - 10.1007/s11010-022-04640-9 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2023 Oct;478(10):2173-2190. doi: 10.1007/s11010-022-04640-9. 
      Epub 2023 Jan 25.