PMID- 36696497
OWN - NLM
STAT- MEDLINE
DCOM- 20230127
LR  - 20230204
IS  - 2375-2548 (Electronic)
IS  - 2375-2548 (Linking)
VI  - 9
IP  - 4
DP  - 2023 Jan 25
TI  - Stacking the odds: Multiple sites for HSV-1 latency.
PG  - eadf4904
LID - 10.1126/sciadv.adf4904 [doi]
LID - eadf4904
AB  - A hallmark of herpes simplex virus (HSV) infection is the establishment of latent 
      virus in peripheral sensory ganglia of the latently infected host. We and others 
      originally reported that the latency-associated transcript (LAT) is the only 
      abundantly expressed viral gene in neurons within trigeminal ganglia (TG) of a 
      latently infected host. Here, we investigated the possible contribution of 
      various cells [i.e., B cells, dendritic cells (DCs), fibroblasts, glial cells, 
      innate lymphoid cells (ILCs), macrophages, microglia, monocytes, natural killer 
      cells, neurons, neutrophils, and T cells] isolated from TG of latently infected 
      mice. Our results demonstrated that all of these cell types contain LAT, with 
      DCs, neurons, and ILCs having the most LAT(+) cells. These results suggest that 
      HSV-1 can establish a quiescent/latent infection in a subset of nonneuronal 
      cells, which enhances the chances that the virus will survive in its host.
FAU - Wang, Shaohui
AU  - Wang S
AUID- ORCID: 0000-0001-7764-0581
AD  - Center for Neurobiology and Vaccine Development, Ophthalmology Research, 
      Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
FAU - Song, Xueying
AU  - Song X
AD  - Applied Genomics, Computation, and Translational Core, Cedars-Sinai Medical 
      Center, Los Angeles, CA, USA.
FAU - Rajewski, Alex
AU  - Rajewski A
AUID- ORCID: 0000-0003-3475-1999
AD  - Applied Genomics, Computation, and Translational Core, Cedars-Sinai Medical 
      Center, Los Angeles, CA, USA.
FAU - Santiskulvong, Chintda
AU  - Santiskulvong C
AD  - Applied Genomics, Computation, and Translational Core, Cedars-Sinai Medical 
      Center, Los Angeles, CA, USA.
FAU - Ghiasi, Homayon
AU  - Ghiasi H
AUID- ORCID: 0000-0003-3291-1995
AD  - Center for Neurobiology and Vaccine Development, Ophthalmology Research, 
      Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
LA  - eng
PT  - Journal Article
DEP - 20230125
PL  - United States
TA  - Sci Adv
JT  - Science advances
JID - 101653440
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Herpesvirus 1, Human/physiology
MH  - Immunity, Innate
MH  - Virus Latency
MH  - Lymphocytes/metabolism
MH  - *Herpes Simplex
PMC - PMC9876545
EDAT- 2023/01/26 06:00
MHDA- 2023/01/28 06:00
PMCR- 2023/01/25
CRDT- 2023/01/25 14:03
PHST- 2023/01/25 14:03 [entrez]
PHST- 2023/01/26 06:00 [pubmed]
PHST- 2023/01/28 06:00 [medline]
PHST- 2023/01/25 00:00 [pmc-release]
AID - adf4904 [pii]
AID - 10.1126/sciadv.adf4904 [doi]
PST - ppublish
SO  - Sci Adv. 2023 Jan 25;9(4):eadf4904. doi: 10.1126/sciadv.adf4904. Epub 2023 Jan 
      25.