PMID- 36698793
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 9
DP  - 2022
TI  - Peripapillary and macular microvasculature in neovascular age-related macular 
      degeneration in long-term and recently started anti-VEGF therapy versus healthy 
      controls.
PG  - 1080052
LID - 10.3389/fmed.2022.1080052 [doi]
LID - 1080052
AB  - AIM: To investigate the peripapillary and macular microvasculature in neovascular 
      age-related macular degeneration (nAMD) in recently started versus long-term 
      anti-vascular endothelial growth factor (VEGF) therapy and healthy controls. 
      METHODS: Eyes with nAMD treated in a treat-and-extend regimen were assigned to 
      group 1 (<5 injections) or 2 (>/=20 injections) whereas group 3 constituted the 
      healthy age-matched controls. Blood flow signals were acquired using PLEX((R)) 
      Elite 9000 swept-source optical coherence tomography angiography (OCTA) of the 
      macular and peripapillary regions. Mean ganglion cell complex (GCC) thickness 
      values were quantified using spectral-domain optical coherence tomography 
      (SD-OCT). RESULTS: Including 80 eyes whereof 40 controls, macular superficial 
      perfusion density was significantly reduced in group 1 and 2 compared to controls 
      (p < 0.001; p = 0.010) without a difference between groups 1 and 2. Peripapillary 
      perfusion parameters did not correlate with post-operative intraocular pressure 
      (IOP) or number of anti-VEGF injections. Mean peripapillary flux index was 
      significantly lower in group 2 than in controls (p = 0.023) and significantly 
      decreased in the nasal quadrants for both AMD groups compared to group 3 (p = 
      0.013; p < 0.001). Mean peripapillary perfusion density was significantly reduced 
      in both AMD groups compared to controls (0.515 +/- 0.02 versus 0.556 +/- 0.03, p < 
      0.0001). CONCLUSION: Frequency of anti-VEGF treatment in nAMD and post-operative 
      IOP showed no correlation with peripapillary perfusion parameters, but anti-VEGF 
      treated nAMD patients exhibited partly altered peripapillary perfusion compared 
      to healthy controls. Reduced macular perfusion density of the inner retina in 
      anti-VEGF treated nAMD compared to healthy controls might be discussed as an 
      anti-VEGF treatment effect or a characteristic of nAMD.
CI  - Copyright (c) 2023 Turksever, Hoffmann and Hatz.
FAU - Turksever, Cengiz
AU  - Turksever C
AD  - Medical Retina Department, Vista Augenklinik Binningen, Binningen, Switzerland.
AD  - Faculty of Medicine, University of Basel, Basel, Switzerland.
FAU - Hoffmann, Laura
AU  - Hoffmann L
AD  - Medical Retina Department, Vista Augenklinik Binningen, Binningen, Switzerland.
AD  - Augenklinik, Charite - Universitatsmedizin Berlin, Berlin, Germany.
FAU - Hatz, Katja
AU  - Hatz K
AD  - Medical Retina Department, Vista Augenklinik Binningen, Binningen, Switzerland.
AD  - Faculty of Medicine, University of Basel, Basel, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20230109
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC9870592
OTO - NOTNLM
OT  - age-related macular degeneration
OT  - flux index
OT  - intraocular pressure
OT  - microvasculature
OT  - optical coherence tomography angiography
OT  - perfusion density
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/27 06:00
MHDA- 2023/01/27 06:01
PMCR- 2023/01/09
CRDT- 2023/01/26 02:39
PHST- 2022/10/25 00:00 [received]
PHST- 2022/12/16 00:00 [accepted]
PHST- 2023/01/26 02:39 [entrez]
PHST- 2023/01/27 06:00 [pubmed]
PHST- 2023/01/27 06:01 [medline]
PHST- 2023/01/09 00:00 [pmc-release]
AID - 10.3389/fmed.2022.1080052 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2023 Jan 9;9:1080052. doi: 10.3389/fmed.2022.1080052. 
      eCollection 2022.