PMID- 36699031 OWN - NLM STAT- MEDLINE DCOM- 20230130 LR - 20230208 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 13 DP - 2022 TI - The relationship between sugar-sweetened beverages, sleep disorders, and diabesity. PG - 1041977 LID - 10.3389/fendo.2022.1041977 [doi] LID - 1041977 AB - BACKGROUND: Diabetes and obesity in adults are global issues. Obesity and type 2 diabetes mellitus (T2DM) are increasingly categorized under the umbrella term "diabesity." Health risk factors (HRFs), which include altering sleep habits and reducing sugar-sweetened beverages (SSBs) consumption, have emerged as relatively novel and crucial strategies for preventing and treating diabetes. OBJECTIVE: We aimed to explore: 1) whether SSBs could affect diabesity in China's community; 2) whether HRFs could moderate this relationship; and 3) whether a three-way interaction exists between HRFs, SSBs, and diabesity. METHODS: On December 10, 2018, we investigated diabetes complications in four cities in Anhui Province and obtained basic and lifestyle information using a detailed questionnaire. The primary exposure was SSBs and outcomes were body mass index (BMI) and waist circumference (WC), while glycated hemoglobin (HbA1c) and sleep patterns (including duration and disorders) were considered moderators. RESULTS: Overall, 1920 participants were enrolled, and those who did not complete the questionnaire were excluded. Finally, this study included 1765 participants, with a response rate of 92.0%. The mean age was (57.10 +/- 10.0) years. Patients with lower educational levels were more likely to have a lower prevalence of WC (chi (2) = 2.73) and BMI (chi (2) = 3.47), and some HRFs were positively correlated with WC and BMI. Additionally, SSBs were significantly associated with BMI (beta = 1.29) and WC (beta = 2.97), and there was also differences based on sex, some HRFs, such as HbA1c, FBG and TG, showed higher levels in male participants, whereas TC level was higher in female participants. In the moderation analysis, sleep patterns were also associated with total cholesterol, triglyceride, and BMI. Furthermore, there were three-way interaction effects among HbA1c, sleep patterns, and SSBs on total cholesterol, triglyceride, BMI, and WC. Moreover, sensitivity analysis demonstrated that our results were robust. CONCLUSION: SSBs positively correlated with patterns dose-dependently. Moreover, SSBs could also be associated with sleep patterns, and blood glucose levels were correlated with diabesity. A three-way interaction effect was discovered between SSBs, sleep patterns, blood glucose levels, and patterns. Therefore, understanding the diabesity caused by SSBs and other HRFs can help prevent its occurrence. CI - Copyright (c) 2023 Zhang, Liu, Xu, Wang, Zhang, Jiang, Zhang and the China National Diabetic Chronic Complications Study Group. FAU - Zhang, Yi AU - Zhang Y AD - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China. FAU - Liu, Chao AU - Liu C AD - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Xu, Yijing AU - Xu Y AD - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Wang, Yanlei AU - Wang Y AD - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Zhang, Yulin AU - Zhang Y AD - The Second Clinical Medical College, Anhui Medical University, Hefei, Anhui, China. FAU - Jiang, Tian AU - Jiang T AD - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Zhang, Qiu AU - Zhang Q AD - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. CN - China National Diabetic Chronic Complications Study Group LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230109 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Blood Glucose) RN - 97C5T2UQ7J (Cholesterol) RN - 0 (Glycated Hemoglobin) RN - 0 (Triglycerides) SB - IM MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Blood Glucose MH - Cholesterol MH - *Diabetes Mellitus, Type 2/etiology/complications MH - Glycated Hemoglobin MH - *Obesity/etiology/complications MH - *Sleep Wake Disorders/etiology/complications MH - *Sugar-Sweetened Beverages/adverse effects MH - Triglycerides MH - China PMC - PMC9869278 OTO - NOTNLM OT - BMI OT - diabesity OT - diabetes OT - sugar-sweetened beverage OT - waist circumference COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/01/27 06:00 MHDA- 2023/01/28 06:00 PMCR- 2022/01/01 CRDT- 2023/01/26 02:41 PHST- 2022/09/12 00:00 [received] PHST- 2022/12/08 00:00 [accepted] PHST- 2023/01/26 02:41 [entrez] PHST- 2023/01/27 06:00 [pubmed] PHST- 2023/01/28 06:00 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2022.1041977 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2023 Jan 9;13:1041977. doi: 10.3389/fendo.2022.1041977. eCollection 2022.