PMID- 36699111
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230802
IS  - 2040-6223 (Print)
IS  - 2040-6231 (Electronic)
IS  - 2040-6223 (Linking)
VI  - 14
DP  - 2023
TI  - Hematological parameters and early-onset coronary artery disease: a retrospective 
      case-control study based on 3366 participants.
PG  - 20406223221142670
LID - 10.1177/20406223221142670 [doi]
LID - 20406223221142670
AB  - BACKGROUND: Thrombosis and inflammation are crucial elements in the pathogenesis 
      of cardiovascular disease. Hematological parameters elucidate information 
      involving the inflammatory and blood coagulation processes. OBJECTIVES: The 
      current study explored the association of hematological parameters with EOCAD to 
      identify specific risk factors. DESIGN: A single-center retrospective 
      case-control study was conducted with 1693 coronary artery disease patients and 
      1693 controls. METHODS: Hematological parameters were examined through an 
      automated analyzer. RESULTS: The basophil percentage was significantly reduced in 
      EOCAD (0.43 +/- 0.26, p < 0.001) and MI (0.33 +/- 0.24, p < 0.001) groups compared 
      with controls (0.54 +/- 0.28). The eosinophil percentage was also significantly 
      lower in EOCAD (2.21 +/- 1.71, p < 0.001) and MI (1.71 +/- 2.44, p < 0.001) groups 
      compared with controls (2.41 +/- 1.75). The lymphocyte percentage in patients of 
      EOCAD and MI and controls was 31.65 +/- 7.93, 25.48 +/- 9.43, and 34.82 +/- 7.28, 
      respectively. A significant difference was observed among the groups (p < 0.001). 
      Except for the mean corpuscular hemoglobin (MCH), other red blood cell (RBC) 
      parameters significantly differed between EOCAD patients and controls. The red 
      blood cell distribution width (RDW), hematocrit (HCT), RBC count, mean 
      corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and 
      hemoglobin level were associated with EOCAD prevalence after adjusting for 
      baseline differences. Platelet volume distribution width (PDW) also correlated 
      with EOCAD prevalence (OR(adjust) = 1.087, 95% CI: 1.044-1.131). CONCLUSIONS: 
      Hematological parameters are closely associated with EOCAD. Moreover, leukocyte 
      parameters correlated with the presence and severity of the disease. In addition, 
      erythrocyte parameters were associated with the disease presence but not with the 
      disease severity. Among the platelet parameters, only PDW was related to the 
      disease presence.
CI  - (c) The Author(s), 2023.
FAU - Wang, Huan
AU  - Wang H
AD  - Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Li, Hui
AU  - Li H
AD  - Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Health Management Institute, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Zhao, Cong
AU  - Zhao C
AD  - Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, 
      China.
FAU - Tian, Qing-Wu
AU  - Tian QW
AD  - Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Wang, Qing
AU  - Wang Q
AD  - Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - He, Guo-Wei
AU  - He GW
AD  - Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, 
      Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
AD  - Department of Surgery, Oregon Health and Science University, Portland, OR, USA.
FAU - Lun, Li-Min
AU  - Lun LM
AD  - Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Xuan, Chao
AU  - Xuan C
AUID- ORCID: 0000-0001-8273-0178
AD  - Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, 
      No. 1677, Wutai Mountain Road, Qingdao 266500, China.
LA  - eng
PT  - Journal Article
DEP - 20230118
PL  - United States
TA  - Ther Adv Chronic Dis
JT  - Therapeutic advances in chronic disease
JID - 101532140
CIN - Ther Adv Chronic Dis. 2023 Jul 26;14:20406223231185250. PMID: 37529505
CIN - Ther Adv Chronic Dis. 2023 Jul 26;14:20406223231185248. PMID: 37529506
PMC - PMC9869207
OTO - NOTNLM
OT  - cardiovascular diseases
OT  - early-onset coronary artery disease
OT  - hematological parameters
COIS- The authors declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2023/01/27 06:00
MHDA- 2023/01/27 06:01
PMCR- 2023/01/18
CRDT- 2023/01/26 02:42
PHST- 2022/05/23 00:00 [received]
PHST- 2022/11/15 00:00 [accepted]
PHST- 2023/01/26 02:42 [entrez]
PHST- 2023/01/27 06:00 [pubmed]
PHST- 2023/01/27 06:01 [medline]
PHST- 2023/01/18 00:00 [pmc-release]
AID - 10.1177_20406223221142670 [pii]
AID - 10.1177/20406223221142670 [doi]
PST - epublish
SO  - Ther Adv Chronic Dis. 2023 Jan 18;14:20406223221142670. doi: 
      10.1177/20406223221142670. eCollection 2023.