PMID- 36699515
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 16
DP  - 2022
TI  - Changes in the structure, perfusion, and function of the hippocampus in type 2 
      diabetes mellitus.
PG  - 1070911
LID - 10.3389/fnins.2022.1070911 [doi]
LID - 1070911
AB  - OBJECTIVE: This study aims to explore the changes in the structure, perfusion, 
      and function of the bilateral hippocampus in type 2 diabetes mellitus (T2DM) 
      applying multimodal MRI methods, hoping to provide reliable neuroimaging evidence 
      for the diagnosis of hippocampus-related brain injury in T2DM. METHODS: We 
      recruited 30 T2DM patients and 45 healthy controls (HCs), on which we performed 
      3D T1-weighted images, resting-state functional MRI (rs-fMRI), arterial spin 
      labeling (ASL) sequences, and a series of cognitive tests. Then, we compared the 
      differences of two groups in the cerebral blood flow (CBF) value, amplitude of 
      low-frequency fluctuation (ALFF) value, fractional ALFF (fALFF) value, 
      coherence-based regional homogeneity (Cohe-ReHo) value, and degree centrality 
      (DC) values of the bilateral hippocampus. RESULTS: In the T2DM group, the 
      bilateral hippocampal volumes and the CBF value of the right hippocampus were 
      lower than those in the HCs, while the ALFF value, fALFF value, and Cohe-ReHo 
      value of the bilateral hippocampus were higher than those in the HCs. Correlation 
      analysis showed that fasting blood glucose (FBG) was negatively correlated with 
      the residuals of left hippocampal volume (r = -0.407, P = 0.025) and right 
      hippocampal volume (r = -0.420, P = 0.021). The residual of the auditory-verbal 
      learning test (AVLT) (immediate) score was positively correlated with the 
      residual of right hippocampal volume (r = 0.369, P = 0.045). CONCLUSION: This 
      study indicated that the volume and perfusion of the hippocampus are decreased in 
      T2DM patients that related to chronic hyperglycemia. Local spontaneous neural 
      activity and coordination are increased in the hippocampus of T2DM patients, 
      possibly as an adaptive compensation for cognitive decline.
CI  - Copyright (c) 2023 Li, Li, Zhao, Tan, Chen, Qin, Qiu and Liang.
FAU - Li, Mingrui
AU  - Li M
AD  - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
AD  - Department of Magnetic Resonance Imaging, Zhanjiang First Hospital of Traditional 
      Chinese Medicine, Zhanjiang, China.
FAU - Li, Yifan
AU  - Li Y
AD  - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Zhao, Kui
AU  - Zhao K
AD  - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Tan, Xin
AU  - Tan X
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Chen, Yuna
AU  - Chen Y
AD  - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Qin, Chunhong
AU  - Qin C
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Qiu, Shijun
AU  - Qiu S
AD  - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Liang, Yi
AU  - Liang Y
AD  - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20230109
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC9868830
OTO - NOTNLM
OT  - cerebral blood flow
OT  - hippocampus
OT  - resting-state functional MRI
OT  - type 2 diabetes mellitus
OT  - volume
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/27 06:00
MHDA- 2023/01/27 06:01
PMCR- 2022/01/01
CRDT- 2023/01/26 02:46
PHST- 2022/10/15 00:00 [received]
PHST- 2022/12/06 00:00 [accepted]
PHST- 2023/01/26 02:46 [entrez]
PHST- 2023/01/27 06:00 [pubmed]
PHST- 2023/01/27 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2022.1070911 [doi]
PST - epublish
SO  - Front Neurosci. 2023 Jan 9;16:1070911. doi: 10.3389/fnins.2022.1070911. 
      eCollection 2022.