PMID- 36699697
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231106
IS  - 2296-889X (Print)
IS  - 2296-889X (Electronic)
IS  - 2296-889X (Linking)
VI  - 9
DP  - 2022
TI  - Extracellular vesicles regulate the transmission of insulin resistance and 
      redefine noncommunicable diseases.
PG  - 1024786
LID - 10.3389/fmolb.2022.1024786 [doi]
LID - 1024786
AB  - Noncommunicable diseases (NCDs), such as diabetes and related neurological 
      disorders, are considered to not be directly transmissible from one person to 
      another. However, NCDs may be transmissible in vivo through extracellular 
      vesicles (EVs). A long-term high-fat diet (HFD) can induce a series of health 
      issues like hyperlipidemia, type 2 diabetes mellitus (T2DM), and diabetic 
      peripheral neuropathy (DPN) due to insulin resistance. Multiple molecular 
      signaling changes can stimulate insulin resistance, especially blocking insulin 
      signaling by increased insulin resistance inducer (phosphorylation of negative 
      regulatory sites of insulin receptor substrate (IRS) proteins) and decreased 
      tyrosine phosphorylation of insulin receptor substrate (phosphorylation of 
      positive regulatory sites of IRS), thus leading to reduced phosphorylation of AKT 
      enzymes. Current efforts to treat T2DM and prevent its complications mainly focus 
      on improving insulin sensitivity, enhancing insulin secretion, or supplementing 
      exogenous insulin based on a common assumption that insulin resistance is 
      noncommunicable. However, insulin resistance is transmissible within multiple 
      tissues or organs throughout the body. Exploring the regulatory roles of EVs in 
      developing insulin resistance may provide novel and effective preventive and 
      therapeutic strategies.
CI  - Copyright (c) 2023 Li, Li, Liu and Zha.
FAU - Li, Biao
AU  - Li B
AD  - Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of 
      Tropical Disease Research, National Medical Products Administration Key 
      Laboratory of Cosmetic Safety Evaluation, School of Public Health, Southern 
      Medical University, Guangzhou, Guangdong, China.
FAU - Li, Wan
AU  - Li W
AD  - School of Physical Education, Hubei Minzu University, Enshi, China.
FAU - Liu, Tiancai
AU  - Liu T
AD  - Key Laboratory of Antibody Engineering of Guangdong Higher Education Institutes, 
      School of Laboratory Medicine and Biotechnology, Southern Medical University, 
      Guangzhou, Guangdong, China.
FAU - Zha, Longying
AU  - Zha L
AD  - Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of 
      Tropical Disease Research, National Medical Products Administration Key 
      Laboratory of Cosmetic Safety Evaluation, School of Public Health, Southern 
      Medical University, Guangzhou, Guangdong, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230109
PL  - Switzerland
TA  - Front Mol Biosci
JT  - Frontiers in molecular biosciences
JID - 101653173
PMC - PMC9868246
OTO - NOTNLM
OT  - T2DM
OT  - diabetes
OT  - extracellular vesicle
OT  - insulin receptor substrate
OT  - insulin resistance
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/27 06:00
MHDA- 2023/01/27 06:01
PMCR- 2022/01/01
CRDT- 2023/01/26 02:48
PHST- 2022/08/22 00:00 [received]
PHST- 2022/12/19 00:00 [accepted]
PHST- 2023/01/26 02:48 [entrez]
PHST- 2023/01/27 06:00 [pubmed]
PHST- 2023/01/27 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 1024786 [pii]
AID - 10.3389/fmolb.2022.1024786 [doi]
PST - epublish
SO  - Front Mol Biosci. 2023 Jan 9;9:1024786. doi: 10.3389/fmolb.2022.1024786. 
      eCollection 2022.