PMID- 36700170
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 1687-8337 (Print)
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Linking)
VI  - 2023
DP  - 2023
TI  - The Effect of the Interaction between Abnormal Body Mass Index and Hypertension 
      on the Risk of Type 2 Diabetes.
PG  - 6009414
LID - 10.1155/2023/6009414 [doi]
LID - 6009414
AB  - OBJECTIVE: Many patients with type 2 diabetes have an abnormal body mass index 
      (BMI) and hypertension together, but few studies on the interaction of the two on 
      the risk of T2DM are reported. We aim to explore the effect of the interaction 
      between abnormal BMI and hypertension on the risk of type 2 diabetes mellitus 
      (T2DM) in Uyghur residents. METHODS AND RESULTS: Based on the physical 
      examination data of 27,4819 Uygur residents in Moyu County, a logistic regression 
      model was used to analyze the correlation between BMI abnormality, hypertension, 
      and T2DM disease, and then, the effect of their interaction on the risk of T2DM 
      was evaluated by an additive model and a multiplicative model. The results showed 
      that the detectable rate of T2DM was 5.58%, the proportion of abnormal BMI was 
      59.49%, and the proportion of hypertension was 25.14%. The risk of T2DM in people 
      with an abnormal BMI and hypertension was higher than that in people with a 
      normal weight and without hypertension, and the difference was statistically 
      significant (P < 0.05). The additive model showed that after adjusting for 
      confounding factors such as gender, age, family history of diabetes, abdominal 
      obesity, and alcohol consumption, abnormal BMI and hypertension had a synergistic 
      effect on the risk of T2DM and the evaluation indicators RERI, AP, and S were 
      0.90 (0.32 approximately 1.49), 0.20 (0.11 approximately 0.30), and 1.36 (1.17 approximately 1.57), respectively. But there 
      was no multiplicative interaction between the two (OR = 0.97, (95% CI: 
      0.89 approximately 1.06). 3). CONCLUSION: The interaction between abnormal BMI and hypertension 
      can increase the risk of T2DM, and improving BMI and controlling blood pressure 
      within the normal range can effectively reduce the risk of T2DM.
CI  - Copyright (c) 2023 Conghui Hu et al.
FAU - Hu, Conghui
AU  - Hu C
AUID- ORCID: 0000-0001-9494-9871
AD  - School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China.
FAU - Su, Yinxia
AU  - Su Y
AD  - School of Medical Engineering and Technology, Xinjiang Medical University, 
      Urumqi, Xinjiang, China.
FAU - Hu, Xiaoyuan
AU  - Hu X
AD  - The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 
      China.
FAU - Luo, Kun
AU  - Luo K
AD  - The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 
      China.
FAU - Abudireyimu, Alimire
AU  - Abudireyimu A
AD  - School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China.
FAU - Li, Yuanyuan
AU  - Li Y
AD  - School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China.
FAU - Yao, Hua
AU  - Yao H
AUID- ORCID: 0000-0002-9572-5578
AD  - Health Management Institute of Xinjiang Medical University, Urumqi, Xinjiang, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20230116
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC9870675
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2023/01/27 06:00
MHDA- 2023/01/27 06:01
PMCR- 2023/01/16
CRDT- 2023/01/26 02:54
PHST- 2022/07/30 00:00 [received]
PHST- 2022/12/21 00:00 [revised]
PHST- 2023/01/06 00:00 [accepted]
PHST- 2023/01/26 02:54 [entrez]
PHST- 2023/01/27 06:00 [pubmed]
PHST- 2023/01/27 06:01 [medline]
PHST- 2023/01/16 00:00 [pmc-release]
AID - 10.1155/2023/6009414 [doi]
PST - epublish
SO  - Int J Endocrinol. 2023 Jan 16;2023:6009414. doi: 10.1155/2023/6009414. 
      eCollection 2023.