PMID- 36700264
OWN - NLM
STAT- MEDLINE
DCOM- 20230127
LR  - 20230215
IS  - 2687-4792 (Electronic)
IS  - 2687-4784 (Print)
IS  - 2687-4792 (Linking)
VI  - 34
IP  - 1
DP  - 2023
TI  - Non-vertebral hydatidosis in bone: Difficulties in management.
PG  - 58-62
LID - jdrs.2023.825 [pii]
LID - 10.52312/jdrs.2023.825 [doi]
AB  - OBJECTIVES: This study presents our experience in surgical treatment of 
      extravertebral bone hydatidosis and aims to investigate the utility of specific 
      immunoglobulin E (IgE) in diagnosis and prognosis of the disease. PATIENTS AND 
      METHODS: Between January 1990 and December 2019, a total of 10 patients (6 males, 
      4 females; mean age: 47.2+/-14.7 years; range, 27 to 71 years) with non-vertebral 
      bone hydatidosis surgically treated in our hospital were retrospectively 
      included. Curettage or wide resection was performed in all cases, followed by 
      medical antihelminthic therapy. Specific IgE p2 was studied in seven patients 
      during and at final follow-up. RESULTS: At the time of diagnosis, secondary 
      infection of the cyst was observed as the initial symptom in two patients 
      mimicking an abscess and, in both cases, more surgeries were required without 
      final healing. In two cases, over five specific IgE presented a false negative at 
      the time of diagnosis and it was not correlated with clinical evolution in three 
      cases over seven. In six cases, diagnosis was obtained before surgery. In 
      treatment, pelvic disease had the worst prognosis (none healed) and bacterial 
      overinfection was a common complication after surgery. At the final follow-up, 
      only two femoral cases (20%) were free of disease. Other four cases (three in 
      iliac bone, one in proximal femur) needed several surgeries without healing. The 
      other four patients showed no progression or refused a new surgical treatment. 
      CONCLUSION: Location, bone defect, when it is possible to perform a radical 
      surgery, and associated bacterial overinfection after surgery make cystic 
      hydatidosis in bone an infection very difficult to treat definitively in humans. 
      Negative specific IgE does not exclude bone hydatidosis.
FAU - Garcia-Alvarez, Felicito
AU  - Garcia-Alvarez F
AD  - Servicio de Cirugia Ortopedica y Traumatologia, Hospital Clinico Universitario 
      Lozano Blesa, 50.009 Zaragoza, Spain fegarcia@comz.org.
FAU - Estella, Ruben
AU  - Estella R
FAU - Albareda, Jorge
AU  - Albareda J
LA  - eng
PT  - Journal Article
DEP - 20230114
PL  - Turkey
TA  - Jt Dis Relat Surg
JT  - Joint diseases and related surgery
JID - 101764223
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - Adult
MH  - Middle Aged
MH  - Treatment Outcome
MH  - Retrospective Studies
MH  - *Echinococcosis/complications/diagnosis/surgery
MH  - Prognosis
MH  - Immunoglobulin E
PMC - PMC9903126
COIS- Conflict of Interest: The authors declared no conflicts of interest with respect 
      to the authorship and/or publication of this article.
EDAT- 2023/01/27 06:00
MHDA- 2023/01/28 06:00
PMCR- 2023/01/14
CRDT- 2023/01/26 02:56
PHST- 2022/08/20 00:00 [received]
PHST- 2022/09/13 00:00 [accepted]
PHST- 2023/01/26 02:56 [entrez]
PHST- 2023/01/27 06:00 [pubmed]
PHST- 2023/01/28 06:00 [medline]
PHST- 2023/01/14 00:00 [pmc-release]
AID - jdrs.2023.825 [pii]
AID - 10.52312/jdrs.2023.825 [doi]
PST - ppublish
SO  - Jt Dis Relat Surg. 2023;34(1):58-62. doi: 10.52312/jdrs.2023.825. Epub 2023 Jan 
      14.