PMID- 36701640 OWN - NLM STAT- MEDLINE DCOM- 20240129 LR - 20240204 IS - 1744-5078 (Electronic) IS - 0927-3948 (Linking) VI - 32 IP - 2 DP - 2024 Feb TI - Diagnosis, Treatment, and Prevention of Noninfectious Acute Anterior Uveitis with or without Human Leukocyte Antigen B27 in Adults - Expert Consensus in Taiwan. PG - 226-233 LID - 10.1080/09273948.2023.2165113 [doi] AB - BACKGROUND: Anterior uveitis is the most common anatomical type of uveitis. Patients with noninfectious anterior uveitis may develop various ocular complications and eventually visual impairment. Appropriately differentiating the etiologies can help clinicians to predict the outcome, arrange clinical follow-up, and decide the treatment or prevention strategy. Adequate treatment and effective prevention strategies can reduce the frequency of recurrence and the risk of developing complications. Human leukocyte antigen (HLA)-B27 is the most common positive finding in patients with noninfectious AAU in many countries including Taiwan. PURPOSE: To report a consensus from experienced uveitis specialists and rheumatologists was made in Taiwan. METHODS: A panel of nine ophthalmologists from nine different referral centers with expertise in the management of uveitis and an experienced rheumatologist was held on January 16, 2022. A comprehensive literature review was performed. Differential diagnoses for etiologies, general treatments, and prevention strategies were discussed. Each statement in the consensus was made only if more than 70% of the experts agreed. RESULTS: A flow chart and seven statements regarding the differential diagnoses for etiologies, treatments and preventions, and co-management with rheumatologists were included in the consensus. CONCLUSIONS: This article discusses the general diagnosis, treatment, and prevention of noninfectious acute anterior uveitis, with or without HLA-B27, in adults for general ophthalmologists to improve overall outcomes of these patients. FAU - Chao, Yu-Jang AU - Chao YJ AD - Department of Ophthalmology, Cheng Hsin General Hospital, Taipei, Taiwan, ROC. AD - School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC. FAU - Hung, Jia-Horung AU - Hung JH AUID- ORCID: 0000-0002-9582-439X AD - Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC. AD - Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC. FAU - Lin, Chang-Ping AU - Lin CP AD - Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan, ROC. FAU - Kuo, Hsi-Kung AU - Kuo HK AD - Department of Ophthalmology, Kaohsiung Chang-Gung Memorial Hospital, Kaohsiung, Taiwan, ROC. AD - College of Medicine, Chang Gung University, Taoyuan City, Taiwan, ROC. FAU - Chen, San-Ni AU - Chen SN AUID- ORCID: 0000-0002-0871-381X AD - Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC. AD - Department of Medication, China Medical University, Taichung, Taiwan, ROC. FAU - Hwang, Yih-Shiou AU - Hwang YS AD - College of Medicine, Chang Gung University, Taoyuan City, Taiwan, ROC. AD - Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan City, Taiwan, ROC. AD - Department of Ophthalmology, Chang Gung Memorial Hospital, Xiamen Branch, Xiamen, China. AD - Department of Ophthalmology, Jen-Ai Hospital Dali Branch, Taichung, Taiwan. FAU - Li, Ko-Jen AU - Li KJ AD - Division of Rheumatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC. AD - Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. FAU - Lin, Chun-Ju AU - Lin CJ AUID- ORCID: 0000-0002-7880-9198 AD - Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC. AD - Department of Optometry, Asia University, Taichung, Taiwan, ROC. FAU - Hwang, De-Kuang AU - Hwang DK AD - School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC. AD - Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. FAU - Sheu, Shwu-Jiuan AU - Sheu SJ AUID- ORCID: 0000-0003-2644-2475 AD - Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. AD - Department of Ophthalmology, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. LA - eng PT - Journal Article PT - Review DEP - 20230126 PL - England TA - Ocul Immunol Inflamm JT - Ocular immunology and inflammation JID - 9312169 RN - 0 (HLA-B27 Antigen) SB - IM MH - Adult MH - Humans MH - HLA-B27 Antigen MH - Consensus MH - Taiwan/epidemiology MH - *Uveitis, Anterior/diagnosis/prevention & control MH - *Uveitis/complications MH - Acute Disease MH - *Spondylitis, Ankylosing/complications OTO - NOTNLM OT - Ankylosing spondylitis OT - B27 OT - Taiwan OT - anterior OT - diagnosis OT - human leukocyte antigen OT - prevention OT - spondyloarthropathy OT - treatment OT - uveitis EDAT- 2023/01/27 06:00 MHDA- 2024/01/29 06:43 CRDT- 2023/01/26 15:42 PHST- 2024/01/29 06:43 [medline] PHST- 2023/01/27 06:00 [pubmed] PHST- 2023/01/26 15:42 [entrez] AID - 10.1080/09273948.2023.2165113 [doi] PST - ppublish SO - Ocul Immunol Inflamm. 2024 Feb;32(2):226-233. doi: 10.1080/09273948.2023.2165113. Epub 2023 Jan 26.