PMID- 36703927
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 13
DP  - 2022
TI  - Exaggerated exercise pressor reflex in male UC Davis type 2 diabetic rats is due 
      to the pathophysiology of the disease and not aging.
PG  - 1063326
LID - 10.3389/fphys.2022.1063326 [doi]
LID - 1063326
AB  - Introduction: Studies in humans and animals have found that type 2 diabetes 
      mellitus (T2DM) exaggerates the blood pressure (BP) response to exercise, which 
      increases the risk of adverse cardiovascular events such as heart attack and 
      stroke. T2DM is a chronic disease that, without appropriate management, 
      progresses in severity as individuals grow older. Thus, it is possible that aging 
      may also exaggerate the BP response to exercise. Therefore, the purpose of the 
      current study was to determine the effect of the pathophysiology of T2DM on the 
      exercise pressor reflex independent of aging. Methods: We compared changes in 
      peak pressor (mean arterial pressure; DeltaMAP), BP index (DeltaBPi), heart rate (DeltaHR), 
      and HR index (DeltaHRi) responses to static contraction, intermittent contraction, 
      and tendon stretch in UCD-T2DM rats to those of healthy, age-matched Sprague 
      Dawley rats at three different stages of the disease. Results: We found that the 
      DeltaMAP, DeltaBPi, DeltaHR, and DeltaHRi responses to static contraction were significantly 
      higher in T2DM rats (DeltaMAP: 29 +/- 4 mmHg; DeltaBPi: 588 +/- 51 mmHg*s; DeltaHR: 22 +/- 5 bpm; 
      DeltaHRi: 478 +/- 45 bpm*s) compared to controls (DeltaMAP: 10 +/- 1 mmHg, p < 0.0001; DeltaBPi: 
      121 +/- 19 mmHg*s, p < 0.0001; DeltaHR: 5 +/- 2 bpm, p = 0.01; DeltaHRi: 92 +/- 19 bpm*s, p < 
      0.0001) shortly after diabetes onset. Likewise, the DeltaMAP, DeltaBPi, and DeltaHRi to 
      tendon stretch were significantly higher in T2DM rats (DeltaMAP: 33 +/- 7 mmHg; DeltaBPi: 
      697 +/- 70 mmHg*s; DeltaHRi: 496 +/- 51 bpm*s) compared to controls (DeltaMAP: 12 +/- 5 mmHg, p 
      = 0.002; DeltaBPi: 186 +/- 30 mmHg*s, p < 0.0001; DeltaHRi: 144 +/- 33 bpm*s, p < 0.0001) 
      shortly after diabetes onset. The DeltaBPi and DeltaHRi, but not DeltaMAP, to intermittent 
      contraction was significantly higher in T2DM rats (DeltaBPi: 543 +/- 42 mmHg*s; DeltaHRi: 
      453 +/- 53 bpm*s) compared to controls (DeltaBPi: 140 +/- 16 mmHg*s, p < 0.0001; DeltaHRi: 
      108 +/- 22 bpm*s, p = 0.0002) shortly after diabetes onset. Discussion: Our 
      findings suggest that the exaggerated exercise pressor reflex and mechanoreflex 
      seen in T2DM are due to the pathophysiology of the disease and not aging.
CI  - Copyright (c) 2023 Huo, Grotle, McCuller, Samora, Stanhope, Havel, Harrison and 
      Stone.
FAU - Huo, Yu
AU  - Huo Y
AD  - Department of Kinesiology and Health Education, The University of Texas at 
      Austin, Austin, TX, United States.
FAU - Grotle, Ann-Katrin
AU  - Grotle AK
AD  - Department of Sport, Food and Natural Sciences, Western Norway University of 
      Applied Science, Bergen, Norway.
FAU - McCuller, Richard K
AU  - McCuller RK
AD  - Department of Kinesiology and Health Education, The University of Texas at 
      Austin, Austin, TX, United States.
FAU - Samora, Milena
AU  - Samora M
AD  - Department of Kinesiology and Health Education, The University of Texas at 
      Austin, Austin, TX, United States.
FAU - Stanhope, Kimber L
AU  - Stanhope KL
AD  - Department of Molecular Biosciences, School of Veterinary Medicine and Department 
      of Nutrition, University of California, Davis, Davis, CA, United States.
FAU - Havel, Peter J
AU  - Havel PJ
AD  - Department of Molecular Biosciences, School of Veterinary Medicine and Department 
      of Nutrition, University of California, Davis, Davis, CA, United States.
FAU - Harrison, Michelle L
AU  - Harrison ML
AD  - Department of Kinesiology and Health Education, The University of Texas at 
      Austin, Austin, TX, United States.
FAU - Stone, Audrey J
AU  - Stone AJ
AD  - Department of Kinesiology and Health Education, The University of Texas at 
      Austin, Austin, TX, United States.
LA  - eng
PT  - Journal Article
DEP - 20230110
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC9871248
OTO - NOTNLM
OT  - autonomic control of circulation
OT  - blood pressure
OT  - cardiovascular response
OT  - mechanoreflex
OT  - metaboreflex
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/28 06:00
MHDA- 2023/01/28 06:01
PMCR- 2023/01/10
CRDT- 2023/01/27 02:17
PHST- 2022/10/06 00:00 [received]
PHST- 2022/12/16 00:00 [accepted]
PHST- 2023/01/27 02:17 [entrez]
PHST- 2023/01/28 06:00 [pubmed]
PHST- 2023/01/28 06:01 [medline]
PHST- 2023/01/10 00:00 [pmc-release]
AID - 1063326 [pii]
AID - 10.3389/fphys.2022.1063326 [doi]
PST - epublish
SO  - Front Physiol. 2023 Jan 10;13:1063326. doi: 10.3389/fphys.2022.1063326. 
      eCollection 2022.