PMID- 36704541
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 2052-4374 (Print)
IS  - 2052-4374 (Electronic)
IS  - 2052-4374 (Linking)
VI  - 34
DP  - 2022
TI  - Exposure to polycyclic aromatic hydrocarbons and serum total IgE in the Korean 
      adults: the Third Korean National Environmental Health Survey (2015-2017).
PG  - e43
LID - 10.35371/aoem.2022.34.e43 [doi]
LID - e43
AB  - BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) have become common pollutants 
      with industrial development. Although the effect of exposure to PAHs on allergic 
      disease in humans has been evaluated, evidence of an association is sparse. The 
      association between PAH exposure and serum total immunoglobulin E (IgE) levels 
      was evaluated in Korean adults. METHODS: In total, this study included 3,269 
      participants in the Third Korean National Environmental Health Survey 
      (2015-2017). Four urinary PAH metabolites were used to assessed exposure to PAHs: 
      1-hydroxypyrene, 1-hydroxyphenanthrene, 2-naphthol, and 2-hydroxyfluorene. The 
      analyses were performed on 3 cutoff levels (100 IU/mL, 114 IU/mL, and 150 IU/mL) 
      set as the total IgE elevation. Prevalence of total IgE elevation by PAH exposure 
      group and general characteristics (age, sex, BMI, smoking, alcohol drinking, and 
      occupation) were analyzed using the Rao-Scott chi(2) test. Multiple logistic 
      regression analyses were conducted to calculate adjusted odds ratios (ORs) for 
      total IgE elevation by PAH exposure groups. RESULTS: Total IgE elevation differed 
      significantly by age, sex, smoking status, alcohol drinking status, and 
      occupation. For 2-hydroxyfluorene, the fourth quartile showed a significant 
      association with IgE elevation compared to the first quartile in the analyses of 
      cutoff-level 100 IU/mL (OR: 1.372, 95% confidence interval [CI]: 1.007-1.869) and 
      114 IU/mL (OR: 1.643, 95% CI: 1.167-2.312). In the analysis of cutoff-level 150 
      IU/mL, the adjusted ORs of the third and fourth quartile of 2-hydroxyfluorene 
      were significantly higher than the first quartile (3rd quartile: OR: 1.478, 95% 
      CI: 1.034-2.113; 4th quartile: OR: 1.715, 95% CI: 1.161-2.534). However, there 
      were no significant positive associations for the other metabolites. CONCLUSIONS: 
      This study implied that PAHs exposure is associated with total IgE elevation in 
      Korean adults. More research is needed to confirm the effect of exposure to PAHs 
      on serum IgE and allergic diseases.
CI  - Copyright (c) 2022 Korean Society of Occupational & Environmental Medicine.
FAU - Jo, Jeong Hun
AU  - Jo JH
AUID- ORCID: 0000-0002-8982-3649
AD  - Department of Occupational and Environmental Medicine, Inje University Haeundae 
      Paik Hospital, Busan, Korea.
FAU - Kim, Dae Hwan
AU  - Kim DH
AUID- ORCID: 0000-0002-0521-3561
AD  - Department of Occupational and Environmental Medicine, Inje University Haeundae 
      Paik Hospital, Busan, Korea.
FAU - Ryu, Ji Young
AU  - Ryu JY
AUID- ORCID: 0000-0002-9797-5853
AD  - Department of Occupational and Environmental Medicine, Inje University Haeundae 
      Paik Hospital, Busan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20221214
PL  - Korea (South)
TA  - Ann Occup Environ Med
JT  - Annals of occupational and environmental medicine
JID - 101609244
PMC - PMC9836823
OTO - NOTNLM
OT  - Allergens
OT  - Environmental pollutants
OT  - Hypersensitivity
OT  - Immunoglobulin E
OT  - Polycyclic aromatic hydrocarbons
COIS- Competing interests: The authors declare that they have no competing interests.
EDAT- 2023/01/28 06:00
MHDA- 2023/01/28 06:01
PMCR- 2022/12/14
CRDT- 2023/01/27 02:27
PHST- 2022/08/05 00:00 [received]
PHST- 2022/10/07 00:00 [revised]
PHST- 2022/11/15 00:00 [revised]
PHST- 2022/11/15 00:00 [accepted]
PHST- 2023/01/27 02:27 [entrez]
PHST- 2023/01/28 06:00 [pubmed]
PHST- 2023/01/28 06:01 [medline]
PHST- 2022/12/14 00:00 [pmc-release]
AID - 10.35371/aoem.2022.34.e43 [doi]
PST - epublish
SO  - Ann Occup Environ Med. 2022 Dec 14;34:e43. doi: 10.35371/aoem.2022.34.e43. 
      eCollection 2022.