PMID- 36704768
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230214
IS  - 1643-8876 (Print)
IS  - 2299-0038 (Electronic)
IS  - 1643-8876 (Linking)
VI  - 21
IP  - 4
DP  - 2022 Dec
TI  - Association of age at menopause with type 2 diabetes mellitus in postmenopausal 
      women in the United States: National Health and Nutrition Examination Survey 
      2011-2018.
PG  - 229-235
LID - 10.5114/pm.2022.123514 [doi]
AB  - INTRODUCTION: The present study aimed to examine the impact of age at menopause 
      on the type 2 diabetes mellitus (T2DM) risk in postmenopausal women. MATERIAL AND 
      METHODS: We included 4,968 postmenopausal women from the National Health and 
      Nutrition Examination Survey 2011-2018. Age at menopause was measured by single 
      year and categorically (< 40 years, 40-44 years, 45-54 years, 55 years and 
      above). The outcome variable T2DM was measured with self-report and fasting blood 
      glucose level. We performed logistic regression to estimate the odds ratio (OR) 
      (95% confidence interval [CI]). Linear regression was used to examine the 
      correlation between age at menopause and age at T2DM. RESULTS: Of the 4,968 
      postmenopausal women, 796 (16.0%) had T2DM after menopause. The mean age at 
      menopause was 44.2 years. The mean age at T2DM was 57.2 years. Adjusting for 
      potential confounders, the ORs for the association between age at menopause of < 
      40 years, 40-44 years and >/= 55 years and T2DM were 1.97 (95% CI: 1.47-2.63), 1.27 
      (95% CI: 0.90-1.79) and 0.98 (95% CI: 0.66-1.45), respectively, compared to women 
      having menopause at age 45 to 54 years. Each increase by 1 year in age at 
      menopause was associated with a 3% reduction in the prevalence of T2DM (95% CI: 
      2-5). Age at menopause was significantly correlated with age at T2DM. Each 1-year 
      increase in age at menopause might lead to a decrease of 0.39 years in age at 
      T2DM. CONCLUSIONS: Premature menopause was associated with increased T2DM risk in 
      women. The earlier menopause occurs, the younger is the age at which T2DM may 
      occur.
CI  - Copyright (c) 2022 Termedia.
FAU - Xing, Zailing
AU  - Xing Z
AD  - College of Public Health, University of South Florida, Tampa, United States.
FAU - Kirby, Russell S
AU  - Kirby RS
AD  - Birth Defects Surveillance Program, Chiles Center, College of Public Health, 
      University of South Florida, Tampa, United States.
AD  - College of Public Health, University of South Florida, Tampa, United States.
FAU - Alman, Amy C
AU  - Alman AC
AD  - College of Public Health, University of South Florida, Tampa, United States.
LA  - eng
PT  - Journal Article
DEP - 20221230
PL  - Poland
TA  - Prz Menopauzalny
JT  - Przeglad menopauzalny = Menopause review
JID - 101263235
PMC - PMC9871996
OTO - NOTNLM
OT  - age at menopause
OT  - menopause
OT  - type 2 diabetes
OT  - women
COIS- The authors report no conflict of interest.
EDAT- 2023/01/28 06:00
MHDA- 2023/01/28 06:01
PMCR- 2022/12/01
CRDT- 2023/01/27 02:33
PHST- 2022/03/25 00:00 [received]
PHST- 2022/04/19 00:00 [accepted]
PHST- 2023/01/27 02:33 [entrez]
PHST- 2023/01/28 06:00 [pubmed]
PHST- 2023/01/28 06:01 [medline]
PHST- 2022/12/01 00:00 [pmc-release]
AID - 49549 [pii]
AID - 10.5114/pm.2022.123514 [doi]
PST - ppublish
SO  - Prz Menopauzalny. 2022 Dec;21(4):229-235. doi: 10.5114/pm.2022.123514. Epub 2022 
      Dec 30.