PMID- 36704810
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 2671-8804 (Electronic)
IS  - 2671-8790 (Print)
IS  - 2671-8790 (Linking)
VI  - 36
IP  - 4
DP  - 2022 Dec 31
TI  - Trends in contemporary advanced heart failure management: an in-depth review over 
      30 years of heart transplant service in Hong Kong.
PG  - 267-277
LID - 10.4285/kjt.22.0038 [doi]
AB  - BACKGROUND: The year 2022 marks the 30th anniversary of heart transplant service 
      in Hong Kong (HK). In this study, we describe prevailing trends and outcomes of 
      advanced heart failure (AHF), including heart transplantations (HTx), in HK over 
      the past 30 years. METHODS: Trends in heart failure prevalence in HK from 1993 to 
      2021 were analyzed based on data from the Hospital Authority Clinical Data and 
      Reporting System. All AHF patients referred for HTx consideration between 1992 
      and 2021 were reviewed. The bridge-to-transplant (BTT) utilization of short-term 
      mechanical circulatory support (ST-MCS) devices, including venoarterial 
      extracorporeal membrane oxygenation (VA-ECMO) and durable left ventricular assist 
      devices (LVADs), from 2010 to 2021 was reviewed. RESULTS: Overall, 237 heart 
      transplants were performed in HK, with 10-year posttransplant and median survival 
      of 68.1% and 18.7 years, respectively. An increase in AHF clinic referrals was 
      correlated with increasing heart failure prevalence (R(2)=0.635, P<0.001). In 
      total, 146 referrals were made for ST-MCS, and an observed increase in ST-MCS 
      referrals was correlated with increasing VA-ECMO utilization (R(2)=0.849, 
      P<0.001). Among 62 patients accepted for AHF therapy, those with durable LVAD 
      implementation had better 1-year survival (71.5%) than those receiving an 
      extracorporeal CentriMag (Levitronix) device as BTT (40%, P=0.008). In total, 143 
      LVADs were implanted, with 130 as BTT or bridge-to-candidacy (BTC) methods. The 
      survival rate among the 130 BTT/BTC LVAD patients resembled that of HTx 
      recipients (73.8% vs. 69.8% at 9 years, P=0.296). CONCLUSIONS: The burden of AHF 
      management has increased and gained complexity over the past 30 years in Hong 
      Kong.
CI  - (c) 2022 The Korean Society for Transplantation.
FAU - Fan, Yue Yan Katherine
AU  - Fan YYK
AUID- ORCID: 0000-0002-0604-8166
AD  - Cardiac Medical Unit, Grantham Hospital, Hong Kong.
FAU - Wong, Ka Lam
AU  - Wong KL
AUID- ORCID: 0000-0002-5328-0320
AD  - Cardiac Medical Unit, Grantham Hospital, Hong Kong.
FAU - Ho, Ka Lai Cally
AU  - Ho KLC
AUID- ORCID: 0000-0002-5735-9351
AD  - Department of Cardiothoracic Surgery, Queen Mary Hospital, Hong Kong.
FAU - Chan, Tai Leung Daniel
AU  - Chan TLD
AUID- ORCID: 0000-0002-0043-1252
AD  - Department of Cardiothoracic Surgery, Queen Mary Hospital, Hong Kong.
FAU - Lee, Oswald Joseph
AU  - Lee OJ
AUID- ORCID: 0000-0001-7284-5246
AD  - Department of Cardiothoracic Surgery, Queen Mary Hospital, Hong Kong.
FAU - Yung, Chi Yui
AU  - Yung CY
AUID- ORCID: 0000-0002-0506-4332
AD  - Cardiac Medical Unit, Grantham Hospital, Hong Kong.
FAU - Lun, Kin Shing
AU  - Lun KS
AUID- ORCID: 0000-0003-3899-4744
AD  - Cardiology Centre, Department of Paediatrics and Adolescent Medicine, Hong Kong 
      Children's Hospital, Hong Kong.
FAU - Chau, Mo Chee Elaine
AU  - Chau MCE
AUID- ORCID: 0000-0002-3141-2740
AD  - Department of Cardiology, Hong Kong Sanatorium and Hospital, Hong Kong.
FAU - Chiu, Shui Wah Clement
AU  - Chiu SWC
AUID- ORCID: 0000-0002-4411-2034
AD  - Department of Cardiothoracic Surgery, Hong Kong Sanatorium and Hospital, Hong 
      Kong.
FAU - Cheng, Lik Cheung
AU  - Cheng LC
AUID- ORCID: 0000-0002-2191-5790
AD  - Department of Surgery, Hong Kong University School of Clinical Medicine, Hong 
      Kong.
FAU - Au, Wing Kuk Timmy
AU  - Au WKT
AUID- ORCID: 0000-0002-6196-7317
AD  - Department of Cardiothoracic Surgery, Queen Mary Hospital, Hong Kong.
LA  - eng
PT  - Journal Article
DEP - 20221129
PL  - Korea (South)
TA  - Korean J Transplant
JT  - Korean journal of transplantation
JID - 101775609
PMC - PMC9832593
OTO - NOTNLM
OT  - Heart failure
OT  - Heart transplantation
OT  - Heart-assist devices
COIS- Conflict of Interest No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2023/01/28 06:00
MHDA- 2023/01/28 06:01
PMCR- 2022/11/29
CRDT- 2023/01/27 02:34
PHST- 2022/08/01 00:00 [received]
PHST- 2022/10/05 00:00 [revised]
PHST- 2022/10/06 00:00 [accepted]
PHST- 2023/01/27 02:34 [entrez]
PHST- 2023/01/28 06:00 [pubmed]
PHST- 2023/01/28 06:01 [medline]
PHST- 2022/11/29 00:00 [pmc-release]
AID - kjt-36-4-267 [pii]
AID - 10.4285/kjt.22.0038 [doi]
PST - ppublish
SO  - Korean J Transplant. 2022 Dec 31;36(4):267-277. doi: 10.4285/kjt.22.0038. Epub 
      2022 Nov 29.