PMID- 36705502
OWN - NLM
STAT- MEDLINE
DCOM- 20230131
LR  - 20230202
IS  - 1477-8920 (Print)
IS  - 1477-8920 (Linking)
VI  - 21
IP  - 1
DP  - 2023 Jan
TI  - Vitamin D deficiency in patients with diabetes and its correlation with water 
      fluoride levels.
PG  - 125-137
LID - 10.2166/wh.2022.254 [doi]
AB  - Chronic exposure to fluoride through drinking water has been linked to insulin 
      resistance and resulting type 2 diabetes mellitus (T2DM). Here, we aim to study 
      the impact of water fluoride levels on blood glucose and vitamin D levels. A 
      hospital-based study was conducted on diabetic patients (n = 303) at All India 
      Institute of Medical Sciences (AIIMS), Raebareli outstation patient department 
      (OPD). The relationship between vitamin D or fasting blood glucose levels (BGLs) 
      with water fluoride levels was estimated through Spearman's rank correlation. We 
      found a significant negative correlation between water fluoride and vitamin D 
      levels [r(s) = -0.777, p-value < 0.001] and a positive correlation between water 
      fluoride and fasting BGLs [r(s) = 0.178, p-value <0.05]. The participants 
      residing in fluoride-endemic areas (F > 1.5 mg/L) had higher odds of severe 
      vitamin D deficiency (odds ratio: 5.07, 95% CI: 1.9-13.2, p-value = 0.0009). The 
      results demonstrate that vitamin D deficiency and fasting BGLs are significantly 
      associated with water fluoride levels. This study signifies the role of fluoride 
      toxicity in poor glycemic control and derived vitamin D deficiency. Vitamin D 
      supplementation and the application of standard household water purification 
      devices are recommended to tackle vitamin D deficiency in fluoride-endemic areas.
FAU - Kumar, Pramod
AU  - Kumar P
AD  - Department of General Medicine, All India Institute of Medical Sciences (AIIMS), 
      Raebareli, India.
FAU - Gupta, Rasna
AU  - Gupta R
AD  - Department of Biotechnology, Dr Ram Manohar Lohia Avadh University, Ayodhya, 
      India.
FAU - Gupta, Ankit
AU  - Gupta A
AD  - Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), 
      Raebareli, India E-mail: guptaankitbiochem07@gmail.com.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Water Health
JT  - Journal of water and health
JID - 101185420
RN  - 0 (Blood Glucose)
RN  - Q80VPU408O (Fluorides)
RN  - 059QF0KO0R (Water)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Humans
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Fluorides
MH  - Water
MH  - *Vitamin D Deficiency/epidemiology/complications
MH  - Vitamin D
EDAT- 2023/01/28 06:00
MHDA- 2023/02/01 06:00
CRDT- 2023/01/27 08:54
PHST- 2023/01/27 08:54 [entrez]
PHST- 2023/01/28 06:00 [pubmed]
PHST- 2023/02/01 06:00 [medline]
AID - 10.2166/wh.2022.254 [doi]
PST - ppublish
SO  - J Water Health. 2023 Jan;21(1):125-137. doi: 10.2166/wh.2022.254.