PMID- 36706090
OWN - NLM
STAT- MEDLINE
DCOM- 20230131
LR  - 20230313
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 18
IP  - 1
DP  - 2023
TI  - Aquaporin 5 (AQP5) expression in breast cancer and its clinicopathological 
      characteristics.
PG  - e0270752
LID - 10.1371/journal.pone.0270752 [doi]
LID - e0270752
AB  - The role of aquaporin water channels (AQPs) has become an area of great interest 
      in human carcinogenesis. In this report, we have demonstrated the expression of 
      AQP5 in breast cancer by analyzing 591 tissue samples with 7-year follow-ups. By 
      immunochemistry analysis, AQP5 overexpression was observed in 36% (212/591 
      cases). Then, we have focused on the clinicopathologic variables among cancer 
      tissue samples with strong AQP5 expression (3+ expression, 60/591 cases). The 
      strong AQP5 expression was positively correlated with tumor grade in BCs 
      (p<0.001) and was more frequent in ER/PR-negative BCs than positive ones (14.9% 
      vs. 3.3% and 13.1% vs. 4.8%, respectively, both p<0.001), while Her2/neu-positive 
      status was positively correlated with strong expression of AQP5 (p = 0.005). Of 
      note, breast cancer patients with positive AQP expression (212/591 cases) showed 
      a less favorable breast cancer specific survival rate over 7 years of follow and 
      we further conclude that AQP5 expression is an independent molecular marker 
      associated with worse clinical outcomes. By fluorescence in situ hybridization 
      (FISH), we have identified evidence of gene amplification in 3 of 30 readable 
      breast cancer and further conclude that, in breast cancer, at least some part of 
      AQP5 overexpression is associated with an aberration in the genome level.
CI  - Copyright: (c) 2023 Jang, Moon. This is an open access article distributed under 
      the terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Jang, Se Jin
AU  - Jang SJ
AD  - Department of Pathology, Asan Medical Center, College of Medicine, Ulsan 
      University, Seoul, Republic of Korea.
FAU - Moon, Chulso
AU  - Moon C
AUID- ORCID: 0000-0003-3863-4298
AD  - Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical 
      Institution, Cancer Research Building II, Baltimore, Maryland, United States of 
      America.
AD  - HJM Cancer Research Foundation Corporation, Lutherville, Maryland, United States 
      of America.
LA  - eng
GR  - P50 CA096784/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20230127
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Aquaporin 5)
RN  - 0 (AQP5 protein, human)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Breast Neoplasms/pathology
MH  - Aquaporin 5/genetics/metabolism
MH  - In Situ Hybridization, Fluorescence
PMC - PMC9882752
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/01/28 06:00
MHDA- 2023/02/01 06:00
PMCR- 2023/01/27
CRDT- 2023/01/27 13:43
PHST- 2021/09/22 00:00 [received]
PHST- 2022/06/16 00:00 [accepted]
PHST- 2023/01/27 13:43 [entrez]
PHST- 2023/01/28 06:00 [pubmed]
PHST- 2023/02/01 06:00 [medline]
PHST- 2023/01/27 00:00 [pmc-release]
AID - PONE-D-21-30448 [pii]
AID - 10.1371/journal.pone.0270752 [doi]
PST - epublish
SO  - PLoS One. 2023 Jan 27;18(1):e0270752. doi: 10.1371/journal.pone.0270752. 
      eCollection 2023.