PMID- 36708209
OWN - NLM
STAT- MEDLINE
DCOM- 20230321
LR  - 20230321
IS  - 0722-5091 (Print)
IS  - 0722-5091 (Linking)
VI  - 42
IP  - 2
DP  - 2023 Mar-Apr
TI  - Some CNS sarcomas seen: A 22-year series.
PG  - 54-65
LID - 10.5414/NP301512 [doi]
AB  - AIMS: Central nervous system (CNS) and spine are seldom impacted by primary or 
      metastatic sarcomas. We reviewed our 22-year experience with metastatic versus 
      primary mesenchymal sarcomas in adults versus pediatric patients, additionally 
      asking how many might today undergo nomenclature changes using CNS World Health 
      Organization, 5(th) edition criteria. MATERIALS AND METHODS: Case identification 
      via text word search of pathology databases from our adult and pediatric referral 
      hospitals, 2000 to August 2022, with exclusion of peripheral nervous system and 
      primary chondro-osseous and notochordal tumors. Demographic, immunohistochemical, 
      fluorescence in situ hybridization (FISH), and fusion results performed at the 
      time of original diagnosis were acquired from reports. RESULTS: 57 cases were 
      identified, with a 16 : 15 primary and 19 : 7 metastatic ratio in adult versus 
      pediatric patients. Ewing sarcoma was the most frequent type (n = 18, 7 adult, 11 
      pediatric), with a rare primary PEComa, 2 alveolar soft part sarcomas, and 
      metastatic angiosarcoma in the cohort. Only 3 cases, an intracranial sarcoma, 
      DICER-1 mutant formerly diagnosed as rhabdomyosarcoma, an intracranial 
      mesenchymal tumor, FET::CREB fusion-positive formerly diagnosed as angiomatoid 
      fibrous histiocytoma, and a CIC-rearranged sarcoma required nomenclature updating 
      by CNS WHO5 criteria. CONCLUSIONS: Few primary or metastatic, adult or pediatric, 
      CNS/spinal sarcomas required nomenclature updates; almost all had been 
      satisfactorily classified at the time of diagnosis, using immunohistochemistry, 
      FISH, or fusion results.
FAU - Kleinschmidt-DeMasters, Bette K
AU  - Kleinschmidt-DeMasters BK
FAU - Gilani, Ahmed
AU  - Gilani A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Clin Neuropathol
JT  - Clinical neuropathology
JID - 8214420
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Sarcoma/pathology
MH  - *Sarcoma, Ewing/diagnosis/pathology
MH  - *Bone Neoplasms/pathology
MH  - *Rhabdomyosarcoma
MH  - *Brain Neoplasms/genetics
MH  - Biomarkers, Tumor
EDAT- 2023/01/29 06:00
MHDA- 2023/03/22 06:00
CRDT- 2023/01/28 04:33
PHST- 2023/02/09 00:00 [accepted]
PHST- 2023/01/29 06:00 [pubmed]
PHST- 2023/03/22 06:00 [medline]
PHST- 2023/01/28 04:33 [entrez]
AID - 190049 [pii]
AID - 10.5414/NP301512 [doi]
PST - ppublish
SO  - Clin Neuropathol. 2023 Mar-Apr;42(2):54-65. doi: 10.5414/NP301512.