PMID- 36709023
OWN - NLM
STAT- MEDLINE
DCOM- 20230228
LR  - 20230317
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 222
DP  - 2023 Apr 1
TI  - Cross-sectional associations of persistent organic pollutants measured in adipose 
      tissue and metabolic syndrome in clinically diagnosed middle-aged adults.
PG  - 115350
LID - S0013-9351(23)00142-1 [pii]
LID - 10.1016/j.envres.2023.115350 [doi]
AB  - INTRODUCTION: Although often overlooked in clinical settings, accumulation of 
      persistent organic pollutants (POPs) in visceral adipose tissue (VAT) is thought 
      to be a relevant risk factor for metabolic syndrome (MetS). METHODS: One hundred 
      and seventeen patients undergoing non-oncological surgery were randomly recruited 
      and classified as MetS + if presented 3 out of the 5 MetS components: waist 
      circumference (WC), systolic and diastolic blood pressure (SBP and DBP, 
      respectively), serum glucose, insulin, triglycerides (TG) and high-density 
      lipoprotein (HDL) cholesterol levels, according International Diabetes Federation 
      (IDF) criteria. Seventeen organochlorine pesticides (OCPs) and polychlorinated 
      biphenyls (PCBs) were measured in adipose tissue samples. Linear, logistic and 
      weighted quantile sum (WQS) regression models, adjusted for age and sex, were 
      performed. RESULTS: One third of the participants were males (36.8%) with a 
      median age of 44 years, showing clinical evidences of MetS (35.0%). Adjusted 
      linear regression models showed that WC correlated positively with all OCP 
      concentrations. Higher fasting serum glucose levels were related to higher HCB 
      and gamma-HCH concentrations. The remaining OCPs and PCBs were not associated with 
      this MetS component. HCB was inversely associated with HDL cholesterol levels, 
      while PCB-180 was positively associated. HCB and gamma-HCH concentrations were also 
      positively correlated with DBP and SBP levels. PCB-138 was also positively 
      associated with SBP. Adjusted logistic models revealed that exposure to HCB and 
      gamma-HCH were associated with increased odds of MetS [ORs (95%CI) 1.53 (1.22-1.92) 
      and 1.39 (1.10-1.76) respectively; p < 0.01]. No associations were observed for 
      the remaining POPs. WQS models showed a positive and significant mixture effect 
      of POPs on the odds of MetS (exp [beta] = 2.34; p < 0.001), with gamma-HCH (52.9%), 
      o,p'-DDT (26.9%) and HCB (19.7%) driving the association. CONCLUSIONS: Our 
      findings support that POPs accumulated in VAT, specifically HCB and (gamma)-HCH, 
      are associated with both isolated components and clinically diagnosed SMT.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Reina-Perez, Iris
AU  - Reina-Perez I
AD  - Centro de Investigacion Biomedica y Departamento de Radiologia y Medicina Fisica, 
      Facultad de Medicina, Universidad de Granada, E-18016 Granada, Spain; Instituto 
      de Investigacion Biosanitaria (ibs.GRANADA), E-18012 Granada, Spain.
FAU - Artacho-Cordon, Francisco
AU  - Artacho-Cordon F
AD  - Centro de Investigacion Biomedica y Departamento de Radiologia y Medicina Fisica, 
      Facultad de Medicina, Universidad de Granada, E-18016 Granada, Spain; Instituto 
      de Investigacion Biosanitaria (ibs.GRANADA), E-18012 Granada, Spain; Centro de 
      Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBEResp), 
      E-28029 Madrid, Spain.
FAU - Mustieles, Vicente
AU  - Mustieles V
AD  - Centro de Investigacion Biomedica y Departamento de Radiologia y Medicina Fisica, 
      Facultad de Medicina, Universidad de Granada, E-18016 Granada, Spain; Instituto 
      de Investigacion Biosanitaria (ibs.GRANADA), E-18012 Granada, Spain; Centro de 
      Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBEResp), 
      E-28029 Madrid, Spain.
FAU - Castellano-Castillo, Daniel
AU  - Castellano-Castillo D
AD  - Unidad de Gestion Clinica Intercentro de Oncologia Medica, Hospitales 
      Universitarios Regional y Virgen de la Victoria, Instituto de Investigacion 
      Biomedica de Malaga (IBIMA)-CIMES-UMA-29010 Malaga, Spain.
FAU - Cardona, Fernando
AU  - Cardona F
AD  - Department of Surgical Specialties, Biochemistry and Immunology School of 
      Medicine, University of Malaga, 29010 Malaga, Spain; Unidad de Gestion Clinica de 
      Pediatria, Hospital Universitario Regional de Malaga, Instituto de Investigacion 
      Biomedica de Malaga (IBIMA), 29010 Malaga, Spain.
FAU - Jimenez-Diaz, Inmaculada
AU  - Jimenez-Diaz I
AD  - Instituto de Investigacion Biosanitaria (ibs.GRANADA), E-18012 Granada, Spain.
FAU - Lopez-Medina, Jose A
AU  - Lopez-Medina JA
AD  - Unidad de Gestion Clinica de Endocrinologia, Hospital Universitario Virgen de la 
      Victoria. Instituto de Investigacion Biomedica de Malaga (IBIMA), E-29010 Malaga, 
      Spain.
FAU - Alcaide, Juan
AU  - Alcaide J
AD  - Unidad de Gestion Clinica de Endocrinologia, Hospital Universitario Virgen de la 
      Victoria. Instituto de Investigacion Biomedica de Malaga (IBIMA), E-29010 Malaga, 
      Spain.
FAU - Ocana-Wilhelmi, Luis
AU  - Ocana-Wilhelmi L
AD  - Unidad de Cirugia Metabolica, Hospital Clinico Universitario Virgen de la 
      Victoria, 29010 Malaga, Spain.
FAU - Iribarne-Duran, Luz M
AU  - Iribarne-Duran LM
AD  - Instituto de Investigacion Biosanitaria (ibs.GRANADA), E-18012 Granada, Spain.
FAU - Arrebola, Juan P
AU  - Arrebola JP
AD  - Instituto de Investigacion Biosanitaria (ibs.GRANADA), E-18012 Granada, Spain; 
      Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica 
      (CIBEResp), E-28029 Madrid, Spain; Departmento de Medicina Preventiva y Salud 
      Publica, Facultad de Medicina Universidad de Granada, E-18016 Granada, Spain.
FAU - Olea, Nicolas
AU  - Olea N
AD  - Centro de Investigacion Biomedica y Departamento de Radiologia y Medicina Fisica, 
      Facultad de Medicina, Universidad de Granada, E-18016 Granada, Spain; Instituto 
      de Investigacion Biosanitaria (ibs.GRANADA), E-18012 Granada, Spain; Centro de 
      Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBEResp), 
      E-28029 Madrid, Spain.
FAU - Tinahones, Francisco J
AU  - Tinahones FJ
AD  - Unidad de Gestion Clinica de Pediatria, Hospital Universitario Regional de 
      Malaga, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29010 Malaga, 
      Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad 
      y la Nutricion, (CIBERobn), E-28029 Madrid, Spain. Electronic address: 
      fjtinahones@uma.es.
FAU - Fernandez, Mariana F
AU  - Fernandez MF
AD  - Centro de Investigacion Biomedica y Departamento de Radiologia y Medicina Fisica, 
      Facultad de Medicina, Universidad de Granada, E-18016 Granada, Spain; Instituto 
      de Investigacion Biosanitaria (ibs.GRANADA), E-18012 Granada, Spain; Centro de 
      Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBEResp), 
      E-28029 Madrid, Spain. Electronic address: marieta@ugr.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230126
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - 0 (Persistent Organic Pollutants)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - D4K93Z1TBH (o,p'-DDT)
RN  - 0 (Pesticides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Middle Aged
MH  - Male
MH  - Adult
MH  - Humans
MH  - Female
MH  - *Polychlorinated Biphenyls
MH  - *Metabolic Syndrome
MH  - Persistent Organic Pollutants
MH  - Environmental Exposure
MH  - Hexachlorocyclohexane
MH  - Cross-Sectional Studies
MH  - *Environmental Pollutants/metabolism
MH  - *Hydrocarbons, Chlorinated/analysis
MH  - Adipose Tissue/chemistry
MH  - *Pesticides
MH  - Glucose
OTO - NOTNLM
OT  - Adipose tissue
OT  - Endocrine disruptors
OT  - Hexachlorobenzene (HCB)
OT  - Hexachlorohexane (HCH)
OT  - Metabolic syndrome (MetS)
OT  - Persistent organic pollutants (POPs)
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/01/29 06:00
MHDA- 2023/03/03 06:00
CRDT- 2023/01/28 19:29
PHST- 2022/10/10 00:00 [received]
PHST- 2022/12/27 00:00 [revised]
PHST- 2023/01/22 00:00 [accepted]
PHST- 2023/01/29 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/01/28 19:29 [entrez]
AID - S0013-9351(23)00142-1 [pii]
AID - 10.1016/j.envres.2023.115350 [doi]
PST - ppublish
SO  - Environ Res. 2023 Apr 1;222:115350. doi: 10.1016/j.envres.2023.115350. Epub 2023 
      Jan 26.