PMID- 36709215
OWN - NLM
STAT- MEDLINE
DCOM- 20230301
LR  - 20230429
IS  - 1432-2323 (Electronic)
IS  - 0364-2313 (Linking)
VI  - 47
IP  - 4
DP  - 2023 Apr
TI  - Assessment and Reporting of Perioperative Adverse Events and Complications in 
      Patients Undergoing Inguinal Lymphadenectomy for Melanoma, Vulvar Cancer, and 
      Penile Cancer: A Systematic Review and Meta-analysis.
PG  - 962-974
LID - 10.1007/s00268-022-06882-6 [doi]
AB  - BACKGROUND: Inguinal lymph node dissection (ILND) plays a crucial role in the 
      oncological management of patients with melanoma, penile, and vulvar cancer. This 
      study aims to systematically evaluate perioperative adverse events (AEs) in 
      patients undergoing ILND and its reporting. METHODS: A systematic review was 
      conducted according to PRISMA. PubMed, MEDLINE, Scopus, and Embase were queried 
      to identify studies discussing perioperative AEs in patients with melanoma, 
      penile, and vulvar cancer following ILND. RESULTS: Our search generated 3.469 
      publications, with 296 studies meeting the inclusion criteria. Details of 14.421 
      patients were analyzed. Of these studies, 58 (19.5%) described intraoperative AEs 
      (iAEs) as an outcome of interest. Overall, 68 (2.9%) patients reported at least 
      one iAE. Postoperative AEs were reported in 278 studies, combining data on 10.898 
      patients. Overall, 5.748 (52.7%) patients documented >/=1 postoperative AEs. The 
      most reported ILND-related AEs were lymphatic AEs, with a total of 4.055 (38.8%) 
      events. The pooled meta-analysis confirmed that high BMI (RR 1.09; p = 0.006), >/=1 
      comorbidities (RR 1.79; p = 0.01), and diabetes (RR 1.81; p =  < 0.00001) are 
      independent predictors for any AEs after ILND. When assessing the quality of the 
      AEs reporting, we found 25% of studies reported at least 50% of the required 
      criteria. CONCLUSION: ILND performed in melanoma, penile, and vulvar cancer 
      patients is a morbid procedure. The quality of the AEs reporting is suboptimal. A 
      more standardized AEs reporting system is needed to produce comparable data 
      across studies for furthering the development of strategies to decrease AEs.
CI  - (c) 2023. The Author(s) under exclusive licence to Societe Internationale de 
      Chirurgie.
FAU - Cacciamani, Giovanni E
AU  - Cacciamani GE
AD  - Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck 
      School of Medicine,, University of Southern California, Los Angeles, CA, USA. 
      Giovanni.cacciamani@med.usc.edu.
FAU - Medina, Luis G
AU  - Medina LG
AD  - Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck 
      School of Medicine,, University of Southern California, Los Angeles, CA, USA.
FAU - Sayegh, Aref S
AU  - Sayegh AS
AD  - Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck 
      School of Medicine,, University of Southern California, Los Angeles, CA, USA.
FAU - La Riva, Anibal
AU  - La Riva A
AD  - Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck 
      School of Medicine,, University of Southern California, Los Angeles, CA, USA.
AD  - Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland 
      Clinic Foundation, Cleveland, OH, USA.
FAU - Perez, Laura C
AU  - Perez LC
AD  - Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck 
      School of Medicine,, University of Southern California, Los Angeles, CA, USA.
AD  - Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, 
      MD, USA.
FAU - Eppler, Michael B
AU  - Eppler MB
AD  - Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck 
      School of Medicine,, University of Southern California, Los Angeles, CA, USA.
FAU - Gill, Inderbir
AU  - Gill I
AD  - Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck 
      School of Medicine,, University of Southern California, Los Angeles, CA, USA.
FAU - Sotelo, Rene
AU  - Sotelo R
AUID- ORCID: 0000-0002-8580-8476
AD  - Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck 
      School of Medicine,, University of Southern California, Los Angeles, CA, USA. 
      rene.sotelo@med.usc.edu.
CN  - Complications and Adverse Events in Lymphadenectomy of the Inguinal Area (CALI) 
      project, the International Consensus Panel on Complications in Urology (ICPCU), 
      and the Intraoperative Complications assessment and reporting with Universal 
      Standards (ICARUS) Global Surgical Collaboration
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20230128
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - *Penile Neoplasms/surgery/pathology
MH  - *Vulvar Neoplasms/surgery/etiology
MH  - Lymph Node Excision/adverse effects/methods
MH  - *Melanoma/surgery
MH  - *Lymphatic Vessels/pathology
EDAT- 2023/01/29 06:00
MHDA- 2023/03/03 06:00
CRDT- 2023/01/28 23:18
PHST- 2022/12/14 00:00 [accepted]
PHST- 2023/01/29 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/01/28 23:18 [entrez]
AID - 10.1007/s00268-022-06882-6 [pii]
AID - 10.1007/s00268-022-06882-6 [doi]
PST - ppublish
SO  - World J Surg. 2023 Apr;47(4):962-974. doi: 10.1007/s00268-022-06882-6. Epub 2023 
      Jan 28.