PMID- 36710293
OWN - NLM
STAT- MEDLINE
DCOM- 20230920
LR  - 20230920
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 201
IP  - 11
DP  - 2023 Nov
TI  - Sodium Butyrate Ameliorates Fluorosis-Induced Neurotoxicity by Regulating 
      Hippocampal Glycolysis In Vivo.
PG  - 5230-5241
LID - 10.1007/s12011-023-03583-6 [doi]
AB  - Fluorosis can induce neurotoxicity. Sodium butyrate (SB), a histone deacetylase 
      inhibitor, has important research potential in correcting glucose metabolism 
      disorders and is widely used in a variety of neurological diseases and metabolic 
      diseases, but it is not yet known whether it plays a role in combating 
      fluoride-induced neurotoxicity. This study aims to evaluate the effect of SB on 
      fluoride neurotoxicity and the possible associated mechanisms. The results of HE 
      staining and Morris water maze showed that, in mice exposed to 100 mg/L fluoride 
      for 3 months, the hippocampal cells arranged in loosely with large cell gaps and 
      diminished in number. One thousand milligram per kilogram per day SB treatment 
      improved fluoride-induced neuronal cell damage and spatial learning memory 
      impairment. Western blot results showed that the abundance of malate 
      dehydrogenase 2 (MDH2) and pyruvate dehydrogenase (PDH) in the hippocampus of 
      fluorosis mice was increased, the abundance of pyruvate kinase M (PKM), lactate 
      dehydrogenase (LDH), hexokinase (HK), phosphatidylinositol 3-kinase (PI3K), 
      phosphorylated Akt (P-AKT), and hypoxia-inducible factor 1alpha (HIF-1alpha) was 
      inhibited, and the content of lactate and ATP was decreased. SB treatment 
      reversed the decreased glycolysis in the hippocampus of fluorosis mice. These 
      results suggested that SB could ameliorate fluorosis-induced neurotoxicity, which 
      might be linked with its function in regulating glycolysis as well as inhibition 
      of the PI3K/AKT/HIF-1alpha pathway. Sodium butyrate ameliorates fluorosis-induced 
      neurotoxicity by regulating hippocampal glycolysis in vivo (created with MedPeer 
      (www.medpeer.cn)).
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Li, Yangjie
AU  - Li Y
AD  - College of Basic Medicine, Shenyang Medical College, Shenyang, 110034, China.
FAU - Wang, Zhengdong
AU  - Wang Z
AD  - College of Basic Medicine, Shenyang Medical College, Shenyang, 110034, China.
FAU - Li, Jing
AU  - Li J
AD  - School of Pharmacy, Shenyang Medical College, Shenyang, 110034, China.
FAU - Yu, Yang
AU  - Yu Y
AD  - School of Medical Applied Technology, Shenyang Medical College, Shenyang, 110034, 
      China.
FAU - Wang, Yuan
AU  - Wang Y
AD  - Central Hospital Affiliated to Shenyang Medical College, Shenyang, 110034, China.
FAU - Jin, Xiaoxia
AU  - Jin X
AD  - School of Public Health, Shenyang Medical College, Shenyang, 110034, China.
FAU - Dong, Yun
AU  - Dong Y
AD  - Central Hospital Affiliated to Shenyang Medical College, Shenyang, 110034, China.
FAU - Liu, Qingsong
AU  - Liu Q
AD  - School of Public Health, Shenyang Medical College, Shenyang, 110034, China.
FAU - Duan, Xiaoxu
AU  - Duan X
AD  - School of Public Health, Shenyang Medical College, Shenyang, 110034, China. 
      duanxiaoxu@symc.edu.cn.
FAU - Yan, Nan
AU  - Yan N
AD  - School of Medical Applied Technology, Shenyang Medical College, Shenyang, 110034, 
      China. yannan369@163.com.
LA  - eng
PT  - Journal Article
DEP - 20230130
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - 107-92-6 (Butyric Acid)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - Q80VPU408O (Fluorides)
RN  - EC 2.7.1.137 (Phosphatidylinositol 3-Kinase)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Signal Transduction
MH  - *Proto-Oncogene Proteins c-akt/metabolism
MH  - Butyric Acid/pharmacology
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Fluorides/pharmacology
MH  - Glycolysis
MH  - Phosphatidylinositol 3-Kinase/metabolism
MH  - Lactic Acid/metabolism
MH  - Hippocampus/metabolism
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism/pharmacology
OTO - NOTNLM
OT  - Fluorosis
OT  - Glycolysis
OT  - Nervous system
OT  - PI3K/AKT/HIF-1alpha
OT  - Sodium butyrate
EDAT- 2023/01/30 06:00
MHDA- 2023/09/20 06:42
CRDT- 2023/01/29 23:52
PHST- 2022/10/31 00:00 [received]
PHST- 2023/01/22 00:00 [accepted]
PHST- 2023/09/20 06:42 [medline]
PHST- 2023/01/30 06:00 [pubmed]
PHST- 2023/01/29 23:52 [entrez]
AID - 10.1007/s12011-023-03583-6 [pii]
AID - 10.1007/s12011-023-03583-6 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2023 Nov;201(11):5230-5241. doi: 10.1007/s12011-023-03583-6. 
      Epub 2023 Jan 30.