PMID- 36712965
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 10
DP  - 2022
TI  - Caloric restriction induced epigenetic effects on aging.
PG  - 1079920
LID - 10.3389/fcell.2022.1079920 [doi]
LID - 1079920
AB  - Aging is the subject of many studies, facilitating the discovery of many 
      interventions. Epigenetic influences numerous life processes by regulating gene 
      expression and also plays a crucial role in aging regulation. Increasing data 
      suggests that dietary changes can alter epigenetic marks associated with aging. 
      Caloric restriction (CR)is considered an intervention to regulate aging and 
      prolong life span. At present, CR has made some progress by regulating signaling 
      pathways associated with aging as well as the mechanism of action of 
      intercellular signaling molecules against aging. In this review, we will focus on 
      autophagy and epigenetic modifications to elaborate the molecular mechanisms by 
      which CR delays aging by triggering autophagy, epigenetic modifications, and the 
      interaction between the two in caloric restriction. In order to provide new ideas 
      for the study of the mechanism of aging and delaying aging.
CI  - Copyright (c) 2023 Zhai, Kongsberg, Pan, Hao, Wang and Sun.
FAU - Zhai, Jingfang
AU  - Zhai J
AD  - School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, 
      Shandong First Medical University & Shandong Academy of Medical Sciences, NHC Key 
      Laboratory of biotechnology drugs (Shandong Academy of Medical Sciences), Key Lab 
      for Rare & Uncommon Diseases of Shandong Province, Ji'nan, Shandong, China.
FAU - Kongsberg, William H
AU  - Kongsberg WH
AD  - School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, 
      Shandong First Medical University & Shandong Academy of Medical Sciences, NHC Key 
      Laboratory of biotechnology drugs (Shandong Academy of Medical Sciences), Key Lab 
      for Rare & Uncommon Diseases of Shandong Province, Ji'nan, Shandong, China.
FAU - Pan, Yinbo
AU  - Pan Y
AD  - School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, 
      Shandong First Medical University & Shandong Academy of Medical Sciences, NHC Key 
      Laboratory of biotechnology drugs (Shandong Academy of Medical Sciences), Key Lab 
      for Rare & Uncommon Diseases of Shandong Province, Ji'nan, Shandong, China.
FAU - Hao, Canhua
AU  - Hao C
AD  - School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, 
      Shandong First Medical University & Shandong Academy of Medical Sciences, NHC Key 
      Laboratory of biotechnology drugs (Shandong Academy of Medical Sciences), Key Lab 
      for Rare & Uncommon Diseases of Shandong Province, Ji'nan, Shandong, China.
FAU - Wang, Xiaojing
AU  - Wang X
AD  - School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, 
      Shandong First Medical University & Shandong Academy of Medical Sciences, NHC Key 
      Laboratory of biotechnology drugs (Shandong Academy of Medical Sciences), Key Lab 
      for Rare & Uncommon Diseases of Shandong Province, Ji'nan, Shandong, China.
FAU - Sun, Jie
AU  - Sun J
AD  - School of Pharmacy and Pharmaceutical Sciences & Institute of Materia Medica, 
      Shandong First Medical University & Shandong Academy of Medical Sciences, NHC Key 
      Laboratory of biotechnology drugs (Shandong Academy of Medical Sciences), Key Lab 
      for Rare & Uncommon Diseases of Shandong Province, Ji'nan, Shandong, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230113
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC9880295
OTO - NOTNLM
OT  - aging
OT  - autophagy
OT  - caloric restriction
OT  - drugs
OT  - epigenetic
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/31 06:00
MHDA- 2023/01/31 06:01
PMCR- 2022/01/01
CRDT- 2023/01/30 04:08
PHST- 2022/10/25 00:00 [received]
PHST- 2022/12/31 00:00 [accepted]
PHST- 2023/01/30 04:08 [entrez]
PHST- 2023/01/31 06:00 [pubmed]
PHST- 2023/01/31 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 1079920 [pii]
AID - 10.3389/fcell.2022.1079920 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2023 Jan 13;10:1079920. doi: 10.3389/fcell.2022.1079920. 
      eCollection 2022.