PMID- 36713335
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 1920-8642 (Print)
IS  - 1920-8642 (Linking)
VI  - 14
IP  - 1
DP  - 2023
TI  - Efficacy and safety of remimazolam-based sedation for intensive care unit 
      patients undergoing upper gastrointestinal endoscopy: a cohort study.
PG  - 31-36
LID - 10.5847/wjem.j.1920-8642.2023.020 [doi]
AB  - BACKGROUND: Remimazolam is a novel ultra-short-acting sedative, but its safety 
      and adverse events (AEs) in high-risk patients in the intensive care unit (ICU) 
      setting remain unknown. METHODS: This was a single-center, retrospective study 
      that compared remimazolam to propofol and midazolam in patients undergoing upper 
      gastrointestinal endoscopy. The primary outcome was the incidence of 
      treatment-related AEs. The secondary outcomes were the time to extubation, the 
      length of ICU stay, and the average cost of sedative per case. RESULTS: Of the 88 
      patients analyzed, 47 were treated with remimazolam (mean dose, 7.90+/-4.84 mg), 
      and 41 were treated with propofol (21.19+/-17.98 mg) or midazolam (3.08+/-2.17 mg). 
      There was no statistically significant difference in the average duration of the 
      endoscopic procedure (35.89+/-13.37 min vs. 44.51+/-21.68 min, P=0.133) or the time 
      to extubation (15.00+/-9.75 h vs. 20.59+/-18.71 h, P=0.211) in the remimazolam group 
      (group I) compared to the propofol or midazolam group (group II). ICU stays 
      (5.40+/-2.93 d vs. 4.63+/-3.31 d, P=0.072) and treatment-related AEs (48.61% vs. 
      51.38%, P=0.056) were similar between groups. The average cost of sedative per 
      case was significantly lower in the group I than in the group II (RMB 16.07+/-10.58 
      yuan vs. RMB 24.37+/-15.46 yuan, P=0.016). CONCLUSION: Remimazolam-based sedation 
      was noninferior to the classic sedatives and had lower average cost per case, 
      indicating that it may be used as a promising sedative for high-risk patients 
      during endoscopic procedures in the ICU setting.
CI  - Copyright: (c) World Journal of Emergency Medicine.
FAU - Zhao, Yuan-Rui
AU  - Zhao YR
AD  - Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 
      430060, China.
FAU - Huang, Ke-Sheng
AU  - Huang KS
AD  - Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 
      430060, China.
FAU - Hou, Guo
AU  - Hou G
AD  - Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 
      430060, China.
FAU - Yao, Lan
AU  - Yao L
AD  - Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 
      430060, China.
FAU - Lu, Li-Ping
AU  - Lu LP
AD  - Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 
      430060, China.
FAU - Xu, Song
AU  - Xu S
AD  - Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 
      430060, China.
FAU - Lian, Ying-Tao
AU  - Lian YT
AD  - Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 
      430060, China.
FAU - Yao, Zhun
AU  - Yao Z
AD  - Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 
      430060, China.
FAU - Yu, Zhui
AU  - Yu Z
AD  - Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 
      430060, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - World J Emerg Med
JT  - World journal of emergency medicine
JID - 101549691
PMC - PMC9842476
OTO - NOTNLM
OT  - Endoscopic sedation
OT  - Intensive care unit
OT  - Midazolam
OT  - Propofol
OT  - Remimazolam
COIS- Conflicts of interest: The authors declare that they have no competing interests.
EDAT- 2023/01/31 06:00
MHDA- 2023/01/31 06:01
PMCR- 2023/01/01
CRDT- 2023/01/30 04:14
PHST- 2022/08/26 00:00 [received]
PHST- 2022/12/20 00:00 [accepted]
PHST- 2023/01/30 04:14 [entrez]
PHST- 2023/01/31 06:00 [pubmed]
PHST- 2023/01/31 06:01 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - WJEM-14-31 [pii]
AID - 10.5847/wjem.j.1920-8642.2023.020 [doi]
PST - ppublish
SO  - World J Emerg Med. 2023;14(1):31-36. doi: 10.5847/wjem.j.1920-8642.2023.020.