PMID- 36713712
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 2470-1343 (Electronic)
IS  - 2470-1343 (Linking)
VI  - 8
IP  - 3
DP  - 2023 Jan 24
TI  - Syntheses, Structural Characterization, and Cytotoxicity Assessment of Novel 
      Mn(II) and Zn(II) Complexes of Aroyl-Hydrazone Schiff Base Ligand.
PG  - 3026-3042
LID - 10.1021/acsomega.2c05927 [doi]
AB  - This work describes the syntheses, structural characterization, and biological 
      profile of Mn(II)- and Zn(II)-based complexes 1 and 2 derived from the 
      aroyl-hydrazone Schiff base ligand (L1). The synthesized compounds were 
      thoroughly characterized by elemental analysis, Fourier transform infrared 
      spectroscopy (FTIR), UV-vis, electron paramagnetic resonance (EPR), nuclear 
      magnetic resonance (NMR), and single-crystal X-ray diffraction (s-XRD). Density 
      functional theory (DFT) studies of complexes 1 and 2 were performed to ascertain 
      the structural and electronic properties. Hirshfeld surface analysis was used to 
      investigate different intermolecular interactions that define the stability of 
      crystal lattice structures. To ascertain the therapeutic potential of complexes 1 
      and 2, in vitro interaction studies were carried out with ct-DNA and bovine serum 
      albumin (BSA) using analytical and multispectroscopic techniques, and the results 
      showed more avid binding of complex 2 than complex 1 and L1. The antioxidant 
      potential of complexes 1 and 2 was examined against the 2,2-diphenyl 
      picrylhydrazyl (DPPH) free radical, which revealed better antioxidant ability of 
      the Mn(II) complex. Moreover, the antibacterial activity of synthesized complexes 
      1 and 2 was tested against Gram-positive and Gram-negative bacteria in which 
      complex 2 demonstrated more effective bactericidal activity than L1 and complex 1 
      toward Gram-positive bacteria. Furthermore, the in vitro cytotoxicity assessment 
      of L1 and complexes 1 and 2 was carried out against MDA-MB-231 (triple negative 
      breast cancer) and A549 (lung) cancer cell lines. The cytotoxic results revealed 
      that the polymeric Zn(II) complex exhibited better and selective cytotoxicity 
      against the A549 cancer cell line as was evidenced by its low IC(50) value.
CI  - (c) 2023 The Authors. Published by American Chemical Society.
FAU - Bashir, Masrat
AU  - Bashir M
AD  - Department of Chemistry, Aligarh Muslim University, Aligarh202002, Uttar Pradesh, 
      India.
FAU - Dar, Aijaz A
AU  - Dar AA
AD  - Department of Chemistry, University of Kashmir, Hazratbal, Srinagar190006, Jammu 
      & Kashmir, India.
FAU - Yousuf, Imtiyaz
AU  - Yousuf I
AUID- ORCID: 0000-0002-6255-8945
AD  - Department of Chemistry, Aligarh Muslim University, Aligarh202002, Uttar Pradesh, 
      India.
LA  - eng
PT  - Journal Article
DEP - 20230111
PL  - United States
TA  - ACS Omega
JT  - ACS omega
JID - 101691658
PMC - PMC9878661
COIS- The authors declare no competing financial interest.
EDAT- 2023/01/31 06:00
MHDA- 2023/01/31 06:01
PMCR- 2023/01/11
CRDT- 2023/01/30 04:18
PHST- 2022/09/13 00:00 [received]
PHST- 2022/12/30 00:00 [accepted]
PHST- 2023/01/30 04:18 [entrez]
PHST- 2023/01/31 06:00 [pubmed]
PHST- 2023/01/31 06:01 [medline]
PHST- 2023/01/11 00:00 [pmc-release]
AID - 10.1021/acsomega.2c05927 [doi]
PST - epublish
SO  - ACS Omega. 2023 Jan 11;8(3):3026-3042. doi: 10.1021/acsomega.2c05927. eCollection 
      2023 Jan 24.