PMID- 36713752
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 2772-3747 (Electronic)
IS  - 2772-3747 (Linking)
VI  - 2
IP  - 7
DP  - 2022 Dec
TI  - Clinical and Predictive Value of Computed Tomography Angiography in High-Altitude 
      Pulmonary Hypertension.
PG  - 803-815
LID - 10.1016/j.jacasi.2022.09.014 [doi]
AB  - BACKGROUND: High-altitude pulmonary hypertension (HAPH), as the group 3 pulmonary 
      hypertension, has been less studied so far. The limited medical conditions in the 
      high-altitude plateau are responsible for the delay of the clinical management of 
      HAPH. OBJECTIVES: This study aims to identify the imaging characteristics of HAPH 
      and explore noninvasive assessment of mean pulmonary arterial pressure (mPAP) 
      based on computed tomography angiography (CTA). METHODS: Twenty-five patients 
      with suspected HAPH were enrolled. Right heart catheterization (RHC) and 
      pulmonary angiography were performed. Echocardiography and CTA image data were 
      collected for analysis. A multivariable linear regression model was fit to 
      estimate mPAP (mPAP(predicted)). A Bland-Altman plot and pathological analysis 
      were performed to assess the diagnostic accuracy of this model. RESULTS: Patients 
      with HAPH showed slow blood flow and coral signs in lower lobe pulmonary artery 
      in pulmonary arteriography, and presented trend for dilated pulmonary vessels, 
      enlarged right atrium, and compressed left atrium in CTA (P for trend <0.05). The 
      left lower pulmonary artery-bronchus ratio (odds ratio: 1.13) and the ratio of 
      right to left atrial diameter (odds ratio: 1.09) were significantly associated 
      with HAPH, and showed strong correlation with mPAP(RHC), respectively (r = 0.821 
      and r = 0.649, respectively; all P < 0.0001). The mPAP(predicted) model using 
      left lower artery-bronchus ratio and ratio of right to left atrial diameter as 
      covariates showed high correlation with mPAP(RHC) (r = 0.907; P < 0.0001). 
      Patients with predicted HAPH also had the typical pathological changes of 
      pulmonary hypertension. CONCLUSIONS: Noninvasive mPAP estimation model based on 
      CTA image data can accurately fit mPAP(RHC) and is beneficial for the early 
      diagnosis of HAPH.
CI  - (c) 2022 The Authors.
FAU - Zeng, Yanxi
AU  - Zeng Y
AD  - Department of Cardiology, Shigatse People's Hospital, Tibet, China.
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, 
      Tongji University, Shanghai, China.
FAU - Yu, Qing
AU  - Yu Q
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, 
      Tongji University, Shanghai, China.
FAU - Maimaitiaili, Nuerbiyemu
AU  - Maimaitiaili N
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, 
      Tongji University, Shanghai, China.
FAU - Li, Bingyu
AU  - Li B
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, 
      Tongji University, Shanghai, China.
FAU - Liu, Panjin
AU  - Liu P
AD  - Department of Cardiology, Shigatse People's Hospital, Tibet, China.
FAU - Hou, Yongzhi
AU  - Hou Y
AD  - Department of Ultrasound, Shigatse People's Hospital, Tibet, China.
FAU - Mima
AU  - Mima
AD  - Department of Cardiology, Shigatse People's Hospital, Tibet, China.
FAU - Cirenguojie
AU  - Cirenguojie
AD  - Department of Radiology, Shigatse People's Hospital, Tibet, China.
FAU - Sumit, Gupta
AU  - Sumit G
AD  - Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, Massachusetts, USA.
FAU - Dejizhuoga
AU  - Dejizhuoga
AD  - Department of Cardiology, Shigatse People's Hospital, Tibet, China.
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, 
      Tongji University, Shanghai, China.
FAU - Liu, Yong
AU  - Liu Y
AD  - Department of Radiology, Shanghai Tenth People's Hospital, School of Medicine, 
      Tongji University, Shanghai, China.
FAU - Peng, Wenhui
AU  - Peng W
AD  - Department of Cardiology, Shigatse People's Hospital, Tibet, China.
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, 
      Tongji University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20221213
PL  - United States
TA  - JACC Asia
JT  - JACC. Asia
JID - 9918452380106676
PMC - PMC9877215
OTO - NOTNLM
OT  - ABR, pulmonary artery-bronchus ratio
OT  - HAPH, high-altitude pulmonary hypertension
OT  - LVEF, left ventricle ejection fraction
OT  - PASP, pulmonary arterial systolic pressure
OT  - PH, pulmonary hypertension
OT  - RHC, right heart catheterization
OT  - TRPG, tricuspid regurgitation pressure gradient
OT  - computed tomography
OT  - mPAP, mean pulmonary arterial pressure
OT  - plateau
OT  - pulmonary arterial pressure
OT  - pulmonary artery-bronchus ratio
OT  - rPA, the ratio of main pulmonary artery to aorta diameter
OT  - rRLA, the ratio of right to left atrial diameter
COIS- Supported by the National Natural Science Foundation of China (81900239, 
      82070230, 91939101) and the Clinical Research Plan of SHDC (No. SHDC2020CR4019). 
      The authors have reported that they have no relationships relevant to the 
      contents of this paper to disclose.
EDAT- 2023/01/31 06:00
MHDA- 2023/01/31 06:01
PMCR- 2022/12/13
CRDT- 2023/01/30 04:18
PHST- 2022/04/27 00:00 [received]
PHST- 2022/09/06 00:00 [revised]
PHST- 2022/09/07 00:00 [accepted]
PHST- 2023/01/30 04:18 [entrez]
PHST- 2023/01/31 06:00 [pubmed]
PHST- 2023/01/31 06:01 [medline]
PHST- 2022/12/13 00:00 [pmc-release]
AID - S2772-3747(22)00335-0 [pii]
AID - 10.1016/j.jacasi.2022.09.014 [doi]
PST - epublish
SO  - JACC Asia. 2022 Dec 13;2(7):803-815. doi: 10.1016/j.jacasi.2022.09.014. 
      eCollection 2022 Dec.