PMID- 36714040
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 1687-6962 (Print)
IS  - 1687-6970 (Electronic)
IS  - 1687-6962 (Linking)
VI  - 2023
DP  - 2023
TI  - Impact of Ketamine on Quality of Recovery after Laparoscopic Surgery: A 
      Single-Centre Single-Blinded Trial Using the QoR-15 Questionnaire.
PG  - 8890025
LID - 10.1155/2023/8890025 [doi]
LID - 8890025
AB  - BACKGROUND: The quality of recovery is a cluster of patient-related outcomes that 
      emphasise not only pain but different physical and emotional dimensions. 
      Traditionally, ketamine is used to improve postoperative analgesia and avoid 
      opioid consumption and opioid-related side effects. OBJECTIVE: The present study 
      sought to evaluate if intraoperative ketamine administration (as a part of 
      multimodal analgesia) influences the quality of recovery after laparoscopic 
      surgery. DESIGN: A prospective two-armed, single-blinded trial. Settings. 
      Tertiary single-centre trial between July 2021 and January 2022. Patients. From 
      the 146 patients initially admitted to the study, 127 patients were enrolled, 60 
      in the ketamine group (group K) and 67 in the control group (group NK). 
      Intervention. Both groups received a rigid intraoperative anaesthesia protocol; 
      furthermore, in group K, 0.5 mg/kg of the ideal body weight of ketamine was 
      administered. Main Outcome Measures. The primary outcome was to evaluate the 
      effect of ketamine administration on the postoperative quality of recovery using 
      the Portuguese version of the Quality of Recovery-15 (QoR-15) Questionnaire 24 h 
      after surgery. The total score and minimal clinically significant difference 
      (MCID) of the QoR-15 were compared. Other variables were also assessed such as 
      the presence of emergence delirium (ED), the Numeric Rating Scale (NRS) for pain, 
      and the presence of postoperative nausea and vomiting (PONV). RESULTS: A total of 
      127 patients were allocated to the study groups, 60 in group K and 67 in group 
      NK. Regarding the primary outcome, no differences were found in individual 
      categories (15 items) and in the total score of QoR-15 (p=0.214). Concerning 
      improvement (MCID >/= 8) or worsening (MCID </= 8) in quality of recovery, no 
      difference was found between the groups (24 vs. 32 and 6 vs. 6; p=0.776). 
      Finally, no difference was found in secondary postoperative outcomes including ED 
      (p=0.55), NRS (p=0.401), and PONV (p=0.55). CONCLUSION: In this study, the 
      administration of ketamine in laparoscopic surgery had no impact on the quality 
      of recovery 24 h after surgery. This trial is registered with NCT03724019.
CI  - Copyright (c) 2023 Helder Pereira et al.
FAU - Pereira, Helder
AU  - Pereira H
AUID- ORCID: 0000-0002-5921-8093
AD  - Department of Surgery and Physiology-Faculty of Medicine, University of Porto, 
      Alameda Professor Hernani Monteiro, Porto, Portugal.
AD  - Anaesthesia Department, Centro Hospitalar Universitario de Sao Joao, Alameda 
      Professor Hernani Monteiro, Porto, Portugal.
FAU - Graca, Maria Ines
AU  - Graca MI
AUID- ORCID: 0000-0002-5433-9216
AD  - Anaesthesia Department, Centro Hospitalar Universitario de Sao Joao, Alameda 
      Professor Hernani Monteiro, Porto, Portugal.
FAU - Fonseca, Diana
AU  - Fonseca D
AUID- ORCID: 0000-0002-1774-3631
AD  - Anaesthesia Department, Centro Hospitalar Universitario de Sao Joao, Alameda 
      Professor Hernani Monteiro, Porto, Portugal.
FAU - Mendes-Castro, Alfredo
AU  - Mendes-Castro A
AUID- ORCID: 0000-0002-5363-8628
AD  - Anaesthesia Department, Centro Hospitalar Universitario de Sao Joao, Alameda 
      Professor Hernani Monteiro, Porto, Portugal.
AD  - Department of Community Medicine, Information and Health Decision 
      Sciences-Faculty of Medicine, University of Porto, Alameda Professor Hernani 
      Monteiro, Porto, Portugal.
FAU - Abelha, Fernando
AU  - Abelha F
AUID- ORCID: 0000-0002-2805-2908
AD  - Department of Surgery and Physiology-Faculty of Medicine, University of Porto, 
      Alameda Professor Hernani Monteiro, Porto, Portugal.
AD  - Anaesthesia Department, Centro Hospitalar Universitario de Sao Joao, Alameda 
      Professor Hernani Monteiro, Porto, Portugal.
LA  - eng
SI  - ClinicalTrials.gov/NCT03724019
PT  - Journal Article
DEP - 20230120
PL  - United States
TA  - Anesthesiol Res Pract
JT  - Anesthesiology research and practice
JID - 101532982
PMC - PMC9883102
COIS- The authors declare that they have no conflicts of interest regarding the 
      publication of this article.
EDAT- 2023/01/31 06:00
MHDA- 2023/01/31 06:01
PMCR- 2023/01/20
CRDT- 2023/01/30 04:23
PHST- 2022/11/06 00:00 [received]
PHST- 2023/01/11 00:00 [revised]
PHST- 2023/01/13 00:00 [accepted]
PHST- 2023/01/30 04:23 [entrez]
PHST- 2023/01/31 06:00 [pubmed]
PHST- 2023/01/31 06:01 [medline]
PHST- 2023/01/20 00:00 [pmc-release]
AID - 10.1155/2023/8890025 [doi]
PST - epublish
SO  - Anesthesiol Res Pract. 2023 Jan 20;2023:8890025. doi: 10.1155/2023/8890025. 
      eCollection 2023.