PMID- 36714567 OWN - NLM STAT- MEDLINE DCOM- 20230131 LR - 20230208 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 13 DP - 2022 TI - Multiple statistical models reveal specific volatile organic compounds affect sex hormones in American adult male: NHANES 2013-2016. PG - 1076664 LID - 10.3389/fendo.2022.1076664 [doi] LID - 1076664 AB - BACKGROUND: Some VOCs are identified as endocrine-disrupting chemicals (EDCs), interfering with the effect of sex hormones. However, no studies focused on the common spectrum of environmental VOCs exposure affecting sex hormones in the average male population. OBJECTIVES: We aimed to explore the association between VOCs and sex hormones in American adult males using multiple statistical models. METHODS: The generalized linear (GLM), eXtreme Gradient Boosting (XGBoost), weighted quantile sum (WQS), Bayesian kernel machine regression (BKMR) and stratified models were used to evaluate the associations between Specific Volatile Organic Compounds and sex hormones in American adult male from NHANES 2013-2016. RESULTS: Pearson correlation model revealed the potential co-exposure pattern among VOCs. XGBoost algorithm models and the WQS model suggested the relative importance of VOCs. BKMR models reveal that co-exposure to the VOCs was associated with increased Testosterone (TT), Estradiol (E(2)), SHBG and decreased TT/E(2). GLM models revealed specific VOC exposure as an independent risk factor causing male sex hormones disorders. Stratified analysis identified the high-risk group on the VOCs exposures. We found Blood 2,5-Dimethylfuran in VOCs was the most significant effect on sex hormones in male. Testosterone increased by 213.594 (ng/dL) (124.552, 302.636) and estradiol increased by 7.229 (pg/mL) for each additional unit of blood 2,5-Dimethylfuran (ng/mL). CONCLUSION: This study is an academic illustration of the association between VOCs exposure and sex hormones, suggesting that exposure to VOCs might be associated with sex hormone metabolic disorder in American adult males. CI - Copyright (c) 2023 Wei, Cao, Zhou, Zhang, Zhang, Wang, Xiong, Deng, Xiong, Liu, He, Guo, Shao, Chen and Chen. FAU - Wei, Chengcheng AU - Wei C AD - Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Cao, Li AU - Cao L AD - Department of Orthopaedic, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Zhou, Yuancheng AU - Zhou Y AD - Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Zhang, Wenting AU - Zhang W AD - Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Zhang, Pu AU - Zhang P AD - Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Wang, Miao AU - Wang M AD - Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Xiong, Ming AU - Xiong M AD - Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Deng, Changqi AU - Deng C AD - Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Xiong, Qi AU - Xiong Q AD - Chongqing Medical University, Chongqing, China. FAU - Liu, Weihui AU - Liu W AD - Department of Urology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China. FAU - He, Qingliu AU - He Q AD - Department of Urology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China. FAU - Guo, Yihong AU - Guo Y AD - Department of Urology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China. FAU - Shao, Zengwu AU - Shao Z AD - Department of Orthopaedic, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Chen, Xiaogang AU - Chen X AD - Department of Urology, Huangshi Central Hospital, The Affliated Hospital of Hubei Polytechnic University, Huangshi, China. FAU - Chen, Zhaohui AU - Chen Z AD - Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230112 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Volatile Organic Compounds) RN - 0 (Gonadal Steroid Hormones) RN - 3XMK78S47O (Testosterone) RN - 4TI98Z838E (Estradiol) SB - IM MH - Male MH - Humans MH - United States/epidemiology MH - *Volatile Organic Compounds MH - Nutrition Surveys MH - Bayes Theorem MH - Gonadal Steroid Hormones MH - Testosterone MH - Estradiol MH - Models, Statistical PMC - PMC9877519 OTO - NOTNLM OT - SHBG OT - estradiol (E2) OT - machine learning OT - testosterone (TT) OT - volatile organic compounds (VOCs) COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/01/31 06:00 MHDA- 2023/02/01 06:00 PMCR- 2022/01/01 CRDT- 2023/01/30 04:32 PHST- 2022/10/21 00:00 [received] PHST- 2022/12/13 00:00 [accepted] PHST- 2023/01/30 04:32 [entrez] PHST- 2023/01/31 06:00 [pubmed] PHST- 2023/02/01 06:00 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2022.1076664 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2023 Jan 12;13:1076664. doi: 10.3389/fendo.2022.1076664. eCollection 2022.