PMID- 36714594
OWN - NLM
STAT- MEDLINE
DCOM- 20230131
LR  - 20230619
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - The value of HDL subfractions in predicting cardiovascular outcomes in untreated, 
      diabetic patients with stable coronary artery disease: An age- and gender-matched 
      case-control study.
PG  - 1041555
LID - 10.3389/fendo.2022.1041555 [doi]
LID - 1041555
AB  - OBJECTIVE: The aim of the present study was to examine the value of high-density 
      lipoprotein (HDL) subfractions for predicting cardiovascular events (CVEs) in 
      untreated type 2 diabetes mellitus (T2DM) patients with stable coronary artery 
      disease (SCAD) using an age- and gender-matched case-control study. METHODS: In 
      total, 185 SCAD patients and 185 T2DM patients with SCAD were enrolled and 
      subjected to a clinical follow-up of CVEs. HDL subfractions were analyzed using 
      the Quantimetrix Lipoprint System. The relationship between HDL subfractions and 
      CVEs in T2DM patients with SCAD was evaluated by Kaplan-Meier analysis and Cox 
      proportional hazard models. RESULTS: During a median 37.7-month follow-up, T2DM 
      patients with SCAD had a higher percentage of CVEs compared to SCAD patients 
      (p=0.039). The concentration of the combined intermediate and small HDL-C 
      subfraction (defined as the mixed HDL subfraction) was related to the event 
      incidence in T2DM patients with SCAD (p=0.004), and it was positively associated 
      with increased CVEs even after adjustment in three models. Kaplan-Meier curve 
      analysis indicated that T2DM patients with SCAD in the high mixed HDL subfraction 
      group (>28 mg/dL) had lower event-free survival rates (p=0.008). CONCLUSIONS: 
      Elevated concentration of the mixed HDL subfraction concentration predicts events 
      in T2DM patients with SCAD.
CI  - Copyright (c) 2023 Zhang, Jin, Zhang, Zhu, Dong, Sun, Guo, Dou, Xu and Li.
FAU - Zhang, Wei
AU  - Zhang W
AD  - State Key Laboratory of Cardiovascular Disease, Cardiometabolic Medicine Center, 
      Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing, China.
FAU - Jin, Jinglu
AU  - Jin J
AD  - State Key Laboratory of Cardiovascular Disease, Cardiometabolic Medicine Center, 
      Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing, China.
FAU - Zhang, Huiwen
AU  - Zhang H
AD  - State Key Laboratory of Cardiovascular Disease, Cardiometabolic Medicine Center, 
      Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing, China.
FAU - Zhu, Yaxin
AU  - Zhu Y
AD  - State Key Laboratory of Cardiovascular Disease, Cardiometabolic Medicine Center, 
      Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing, China.
FAU - Dong, Qian
AU  - Dong Q
AD  - State Key Laboratory of Cardiovascular Disease, Cardiometabolic Medicine Center, 
      Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing, China.
FAU - Sun, Jing
AU  - Sun J
AD  - State Key Laboratory of Cardiovascular Disease, Cardiometabolic Medicine Center, 
      Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing, China.
FAU - Guo, Yuanlin
AU  - Guo Y
AD  - State Key Laboratory of Cardiovascular Disease, Cardiometabolic Medicine Center, 
      Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing, China.
FAU - Dou, Kefei
AU  - Dou K
AD  - State Key Laboratory of Cardiovascular Disease, Cardiometabolic Medicine Center, 
      Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing, China.
FAU - Xu, Ruixia
AU  - Xu R
AD  - State Key Laboratory of Cardiovascular Disease, Cardiometabolic Medicine Center, 
      Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing, China.
FAU - Li, JianJun
AU  - Li J
AD  - State Key Laboratory of Cardiovascular Disease, Cardiometabolic Medicine Center, 
      Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230112
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Lipoproteins, HDL)
SB  - IM
EIN - Front Endocrinol (Lausanne). 2023 Jun 01;14:1208564. PMID: 37334289
MH  - Humans
MH  - *Coronary Artery Disease/complications
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Case-Control Studies
MH  - Cholesterol, HDL
MH  - Lipoproteins, HDL
PMC - PMC9877453
OTO - NOTNLM
OT  - cardiovascular events
OT  - coronary artery disease
OT  - diabetes
OT  - high-density lipoprotein subfractions
OT  - predicting value
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/31 06:00
MHDA- 2023/02/01 06:00
PMCR- 2023/01/12
CRDT- 2023/01/30 04:32
PHST- 2022/09/11 00:00 [received]
PHST- 2022/12/28 00:00 [accepted]
PHST- 2023/01/30 04:32 [entrez]
PHST- 2023/01/31 06:00 [pubmed]
PHST- 2023/02/01 06:00 [medline]
PHST- 2023/01/12 00:00 [pmc-release]
AID - 10.3389/fendo.2022.1041555 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 Jan 12;13:1041555. doi: 
      10.3389/fendo.2022.1041555. eCollection 2022.