PMID- 36714920
OWN - NLM
STAT- Publisher
LR  - 20240216
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
DP  - 2023 Feb 3
TI  - Hyperhomocysteinemia increases the risk of vertebrobasilar dissecting aneurysm 
      among the male Han Chinese population: a retrospective case-control study.
PG  - 1-7
LID - 10.1080/00207454.2023.2174024 [doi]
AB  - OBJECT: Vertebrobasilar dissecting aneurysms (VBDAs) are known to have a poor 
      natural history with high rates of re-bleeding and mortality. There is a strong 
      relation between hyperhomocysteinemia (HHcy) and cerebrovascular disease; we 
      perform a retrospective study within the male of Chinese Han population to 
      explore the association between HHcy and VBDAs. METHODS: Eighty-eight male 
      patients with VBDA and Eighty-one male control subjects were evaluated for their 
      serum total homocysteine levels. With multiple logistic regression analysis, the 
      association between HHcy and the risk of VBDAs was estimated. Interaction and 
      stratified analyses were conducted according to age, BMI, smoking status, 
      drinking status, and chronic disease histories. The two-piecewise linear 
      regression model examined the threshold effect. RESULTS: The multivariate 
      logistic regression analyses revealed a significant association between HHcy and 
      VBDAs (odds ratio (OR) = 2.62; 95% confidence interval (CI), 1.02-6.71) after 
      adjusting for classical vascular risk factors. The relationship was stable in all 
      subgroup analysis. The interactive role was not found in the association between 
      HHcy and VBDAs for the potential risk factor. CONCLUSIONS: In summary, our study 
      provides evidence that HHcy can increases the risk of VBDAs in the male Han 
      Chinese population. Further researches with appropriate study designs including 
      sex differences and aneurysm types are needed to verify this association.
FAU - Wang, Qun
AU  - Wang Q
AUID- ORCID: 0000-0002-1559-8530
AD  - Department of Neurosurgery, The First Medical Center, Chinese PLA General 
      Hospital, Haidian District, Beijing, China.
FAU - Liu, Minghang
AU  - Liu M
AD  - Department of Neurosurgery, The First Medical Center, Chinese PLA General 
      Hospital, Haidian District, Beijing, China.
FAU - Zhao, Kai
AU  - Zhao K
AD  - Department of Neurosurgery, The First Medical Center, Chinese PLA General 
      Hospital, Haidian District, Beijing, China.
FAU - Xu, Xinghua
AU  - Xu X
AD  - Department of Neurosurgery, The First Medical Center, Chinese PLA General 
      Hospital, Haidian District, Beijing, China.
FAU - Zhang, JiaShu
AU  - Zhang J
AD  - Department of Neurosurgery, The First Medical Center, Chinese PLA General 
      Hospital, Haidian District, Beijing, China.
FAU - Xu, BaiNan
AU  - Xu B
AD  - Department of Neurosurgery, The First Medical Center, Chinese PLA General 
      Hospital, Haidian District, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20230203
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
SB  - IM
OTO - NOTNLM
OT  - Vertebrobasilar dissecting aneurysms
OT  - case-control study
OT  - homocysteine
OT  - hyperhomocysteinemia
OT  - risk factors
EDAT- 2023/01/31 06:00
MHDA- 2023/01/31 06:00
CRDT- 2023/01/30 04:37
PHST- 2023/01/31 06:00 [pubmed]
PHST- 2023/01/31 06:00 [medline]
PHST- 2023/01/30 04:37 [entrez]
AID - 10.1080/00207454.2023.2174024 [doi]
PST - aheadofprint
SO  - Int J Neurosci. 2023 Feb 3:1-7. doi: 10.1080/00207454.2023.2174024.