PMID- 36714924
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231102
IS  - 1744-764X (Electronic)
IS  - 1474-0338 (Linking)
VI  - 22
IP  - 7
DP  - 2023 Jul-Dec
TI  - The impact of pharmacist intervention on the intravenous-to-oral switch therapy 
      of proton pump inhibitors in cardiovascular surgery.
PG  - 611-619
LID - 10.1080/14740338.2023.2172162 [doi]
AB  - BACKGROUND: The prescriptions of proton pump inhibitors (PPIs) have been widely 
      concerned due to both huge increase in medical costs and possible long-term 
      adverse events (AEs) caused by the improper route of drug administration. The aim 
      of this study was to assess the effectiveness of pharmacist interventions on the 
      clinical outcome and safety of switching from intravenous (IV) to oral PPIs 
      therapy. PATIENTS AND METHODS: A retrospective, single-center, pre- intervention 
      (early -stage)- and intervention (later -stage) study was performed in a Chinese 
      hospital. RESULTS: A total of 1736 patients were included in the study. After 
      12 months of interventions, significant improvements in the number of rational IV 
      to oral switch in patients with oral switch indications were found. The median 
      duration of oral therapy was increased, while the duration of PPIs therapy was 
      decreased. Pharmacist interventions led to significant reductions in mean PPI 
      costs, mean total drug costs, mean hospitalization costs, and the risk for 
      long-term adverse events. CONCLUSION: This study provides important evidence on 
      the beneficial effect of pharmacist interventions on promoting an optimal IV to 
      oral switch of PPIs and substantial cost saving by shortening the duration of IV 
      PPIs therapy and reducing the risk for long-term AEs.
FAU - Bao, Jianan
AU  - Bao J
AD  - Department of Pharmacy, Medical Center of Soochow University, Dushu Lake Hospital 
      Affiliated to Soochow University, Suzhou, Jiangsu, China.
FAU - Zhou, Ling
AU  - Zhou L
AD  - Department of Pharmacy, the First Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, China.
FAU - Xu, Mengying
AU  - Xu M
AD  - Department of Pharmacy, Medical Center of Soochow University, Dushu Lake Hospital 
      Affiliated to Soochow University, Suzhou, Jiangsu, China.
FAU - Ma, Jingjing
AU  - Ma J
AD  - Department of Pharmacy, Medical Center of Soochow University, Dushu Lake Hospital 
      Affiliated to Soochow University, Suzhou, Jiangsu, China.
LA  - eng
PT  - Journal Article
DEP - 20230202
PL  - England
TA  - Expert Opin Drug Saf
JT  - Expert opinion on drug safety
JID - 101163027
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Humans
MH  - *Proton Pump Inhibitors/adverse effects
MH  - *Pharmacists
MH  - Retrospective Studies
MH  - Hospitalization
MH  - Administration, Intravenous
OTO - NOTNLM
OT  - PPI therapy duration
OT  - Proton pump inhibitors
OT  - cost saving
OT  - intravenous-to-oral switch therapy
OT  - pharmacist intervention
EDAT- 2023/01/31 06:00
MHDA- 2023/01/31 06:01
CRDT- 2023/01/30 04:37
PHST- 2023/01/31 06:01 [medline]
PHST- 2023/01/31 06:00 [pubmed]
PHST- 2023/01/30 04:37 [entrez]
AID - 10.1080/14740338.2023.2172162 [doi]
PST - ppublish
SO  - Expert Opin Drug Saf. 2023 Jul-Dec;22(7):611-619. doi: 
      10.1080/14740338.2023.2172162. Epub 2023 Feb 2.