PMID- 36716611
OWN - NLM
STAT- Publisher
LR  - 20231022
IS  - 1769-7131 (Electronic)
IS  - 0987-7053 (Linking)
VI  - 53
IP  - 4
DP  - 2023 Aug
TI  - Patients with neuropathic pain from lumbosacral radiculopathy demonstrate similar 
      pressure pain thresholds and conditioned pain modulation to those with 
      fibromyalgia.
PG  - 102841
LID - S0987-7053(22)00125-3 [pii]
LID - 10.1016/j.neucli.2022.102841 [doi]
AB  - OBJECTIVE: The purpose of the study was to evaluate pain thresholds, impairment 
      of the endogenous pain modulatory system, and self-reported cognitive-emotional 
      and central sensitization-related symptoms among three subject groups: a rarely 
      studied patient cohort with neuropathic pain from lumbosacral radiculopathy 
      (NPLSR), patients with fibromyalgia (FM) and healthy controls (HC). METHODS: 
      Patient-reported pain-related symptomology was evaluated with 
      psychometricallyvalidated questionnaires. Pressure pain threshold (PPT), heat 
      pain threshold (HPT), and cold pain threshold (CPT) were assessed in the low back 
      and contralateral forearm. Conditioned pain modulation (CPM) was evaluated with a 
      recently introduced methodology that accounts for a standard error of 
      measurement. RESULTS: Compared to the HC subjects, the FM and NPLSR subjects had 
      significantly lower pain thresholds and more CPM impairment. No significant 
      differences in PPT and CPM were observed between the FM and NPLSR groups. 
      Significant group differences were found in self-reported symptoms of depression, 
      anxiety, stress, and central sensitization. Self-reported symptom severity 
      increased in a stair-step fashion, with the HC group scoring lowest and FM group 
      scoring highest. CONCLUSION: The NPLSR group manifested CPM dysfunction and 
      pressure hyperalgesia at similar levels to the FM group, indicating that these 
      two chronic pain syndromes, likely based on different pathophysiological 
      mechanisms, in fact share some common pain processing features. However, though 
      both patient groups demonstrated similarities in pain processing, self-reported 
      cognitive-emotional and central sensitization-related symptom severity was 
      significantly higher in the FM cohort, which distinguished them from the chronic 
      NPLSR cohort.
CI  - Copyright (c) 2022 Elsevier Masson SAS. All rights reserved.
FAU - Knezevic, Aleksandar
AU  - Knezevic A
AD  - Faculty of Medicine University of Novi Sad, Serbia; Medical Rehabilitation Clinic 
      University Clinical Centre of Vojvodina, Serbia. Electronic address: 
      aleksandar.knezevic@mf.uns.ac.rs.
FAU - Kovacevic, Milena
AU  - Kovacevic M
AD  - Faculty of Medicine University of Novi Sad, Serbia.
FAU - Jeremic-Knezevic, Milica
AU  - Jeremic-Knezevic M
AD  - Faculty of Medicine University of Novi Sad, Serbia.
FAU - Nikolasevic, Zeljka
AU  - Nikolasevic Z
AD  - Faculty of Medicine University of Novi Sad, Serbia.
FAU - Tomasevic-Todorovic, Snezana
AU  - Tomasevic-Todorovic S
AD  - Faculty of Medicine University of Novi Sad, Serbia; Medical Rehabilitation Clinic 
      University Clinical Centre of Vojvodina, Serbia.
FAU - Zivanovic, Zeljko
AU  - Zivanovic Z
AD  - Faculty of Medicine University of Novi Sad, Serbia; Neurology Clinic University 
      Clinical Centre of Vojvodina, Serbia.
FAU - Spasojevic, Tijana
AU  - Spasojevic T
AD  - Faculty of Medicine University of Novi Sad, Serbia; Medical Rehabilitation Clinic 
      University Clinical Centre of Vojvodina, Serbia.
FAU - Garipi, Enis
AU  - Garipi E
AD  - Faculty of Medicine University of Novi Sad, Serbia; Medical Rehabilitation Clinic 
      University Clinical Centre of Vojvodina, Serbia.
FAU - Vojnovic, Larisa
AU  - Vojnovic L
AD  - Faculty of Medicine University of Novi Sad, Serbia; Medical Rehabilitation Clinic 
      University Clinical Centre of Vojvodina, Serbia.
FAU - Popovic, Dunja
AU  - Popovic D
AD  - Faculty of Medicine University of Novi Sad, Serbia; Medical Rehabilitation Clinic 
      University Clinical Centre of Vojvodina, Serbia.
FAU - Neblett, Randy
AU  - Neblett R
AD  - PRIDE Research Foundation, Dallas, TX, USA.
LA  - eng
PT  - Journal Article
DEP - 20230128
PL  - France
TA  - Neurophysiol Clin
JT  - Neurophysiologie clinique = Clinical neurophysiology
JID - 8804532
SB  - IM
OTO - NOTNLM
OT  - Central Sensitization Inventory
OT  - Chronic pain
OT  - Conditioned pain modulation
OT  - Fibromyalgia
OT  - Lumbar radiculopathy
OT  - Neuropathic pain
OT  - Pain thresholds
COIS- Declaration of Competing Interest None declared.
EDAT- 2023/01/31 06:00
MHDA- 2023/01/31 06:00
CRDT- 2023/01/30 18:11
PHST- 2022/05/07 00:00 [received]
PHST- 2022/11/13 00:00 [revised]
PHST- 2022/12/17 00:00 [accepted]
PHST- 2023/01/31 06:00 [pubmed]
PHST- 2023/01/31 06:00 [medline]
PHST- 2023/01/30 18:11 [entrez]
AID - S0987-7053(22)00125-3 [pii]
AID - 10.1016/j.neucli.2022.102841 [doi]
PST - ppublish
SO  - Neurophysiol Clin. 2023 Aug;53(4):102841. doi: 10.1016/j.neucli.2022.102841. Epub 
      2023 Jan 28.