PMID- 36716931 OWN - NLM STAT- MEDLINE DCOM- 20230310 LR - 20230320 IS - 1872-9711 (Electronic) IS - 0161-813X (Linking) VI - 95 DP - 2023 Mar TI - Cobalt nanoparticles induce mitochondrial damage and beta-amyloid toxicity via the generation of reactive oxygen species. PG - 155-163 LID - S0161-813X(23)00018-9 [pii] LID - 10.1016/j.neuro.2023.01.010 [doi] AB - Exposure to cobalt nanoparticles (CoNPs) has been associated with neurodegenerative disorders, while the mitochondrial-associated mechanisms that mediate their neurotoxicity have yet to be fully characterized. In this study, we reported that CoNPs exposure reduced the survival and lifespan in the nematodes, Caenorhabditis elegans (C. elegans). Moreover, exposure to CoNPs aggravated the induction of paralysis and the aggregation of beta-amyloid (Abeta). These effects were accompanied by reactive oxygen species (ROS) overproduction, ATP reduction as well as mitochondrial fragmentation. Dynamin-related protein 1 (drp-1) activation and ensuing mitochondrial fragmentation have been shown to be associated with CoNPs-reduced survival. In order to address the role of mitochondrial damage and ROS production in CoNPs-induced Abeta toxicity, the mitochondrial reactive oxygen species scavenger mitoquinone (Mito Q) was used. Our results showed that Mito Q pretreatment alleviated CoNPs-induced ROS generation, rescuing mitochondrial dysfunction, thereby lessening the CoNPs-induced Abeta toxicity. Taken together, we show for the first time, that increasing of ROS and the upregulation of drp-1 lead to CoNPs-induced Abeta toxicity. Our novel findings provide in vivo evidence for the mechanisms of environmental toxicant-induced Abeta toxicity, and can afford new modalities for the prevention and treatment of CoNPs-induced neurodegeneration. CI - Copyright (c) 2023 Elsevier B.V. All rights reserved. FAU - Chen, Jingrong AU - Chen J AD - Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. FAU - Chen, Cheng AU - Chen C AD - Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; The key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. FAU - Wang, Na AU - Wang N AD - Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. FAU - Wang, Chunyu AU - Wang C AD - Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. FAU - Gong, Zhaohui AU - Gong Z AD - Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. FAU - Du, Jingxian AU - Du J AD - Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. FAU - Lai, Honglin AU - Lai H AD - Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. FAU - Lin, Xinpei AU - Lin X AD - Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; The key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. FAU - Wang, Wei AU - Wang W AD - Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; The key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. FAU - Chang, Xiangyu AU - Chang X AD - Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; The key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. FAU - Aschner, Michael AU - Aschner M AD - Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 209, 1300 Morris Park Avenue, Bronx, NY 10461, USA. FAU - Guo, Zhenkun AU - Guo Z AD - The key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 209, 1300 Morris Park Avenue, Bronx, NY 10461, USA. FAU - Wu, Siying AU - Wu S AD - Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; The key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. FAU - Li, Huangyuan AU - Li H AD - Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; The key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. Electronic address: lhy@fjmu.edu.cn. FAU - Zheng, Fuli AU - Zheng F AD - Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China; The key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian Province, China. Electronic address: f.zheng@fjmu.edu.cn. LA - eng GR - R01 ES010563/ES/NIEHS NIH HHS/United States GR - R01 ES007331/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20230127 PL - Netherlands TA - Neurotoxicology JT - Neurotoxicology JID - 7905589 RN - 0 (Reactive Oxygen Species) RN - 0 (Amyloid beta-Peptides) RN - 3G0H8C9362 (Cobalt) SB - IM MH - Animals MH - Reactive Oxygen Species/metabolism MH - *Amyloid beta-Peptides/toxicity MH - Cobalt/toxicity MH - Caenorhabditis elegans/metabolism MH - *Nanoparticles/toxicity OTO - NOTNLM OT - Abeta toxicity OT - Caenorhabditis elegans OT - Cobalt nanoparticles OT - Drp-1 OT - Mito Q OT - Reactive oxygen species COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/01/31 06:00 MHDA- 2023/03/11 06:00 CRDT- 2023/01/30 19:26 PHST- 2022/10/25 00:00 [received] PHST- 2023/01/24 00:00 [revised] PHST- 2023/01/25 00:00 [accepted] PHST- 2023/01/31 06:00 [pubmed] PHST- 2023/03/11 06:00 [medline] PHST- 2023/01/30 19:26 [entrez] AID - S0161-813X(23)00018-9 [pii] AID - 10.1016/j.neuro.2023.01.010 [doi] PST - ppublish SO - Neurotoxicology. 2023 Mar;95:155-163. doi: 10.1016/j.neuro.2023.01.010. Epub 2023 Jan 27.