PMID- 36718059
OWN - NLM
STAT- MEDLINE
DCOM- 20230728
LR  - 20230728
IS  - 2772-2716 (Electronic)
IS  - 2772-2708 (Linking)
VI  - 17
IP  - 1
DP  - 2023
TI  - Lymphocytic Esophagitis: A Case Series of Esophageal Disease with Increasing 
      Frequency.
PG  - 79-84
LID - 10.2174/2772270817666230130093341 [doi]
AB  - BACKGROUND: Lymphocytic esophagitis (LE) is a poorly understood clinical finding 
      that has been increasingly identified in the last decade. Previous studies 
      proposed increased frequency of LE in elderly females, as well as associations 
      with smoking and pediatric Crohn's disease. OBJECTIVE: We aimed to determine the 
      patient characteristics and clinical features of our adult LE patients. As 
      inflammation in the esophagus has been linked to cancer, this review also 
      describes this association. However, there are no reported cases of malignant 
      transformation in those with underlying lymphocytic esophagitis. METHODS: We 
      retrospectively reviewed records for patients at the University of Missouri 
      Hospital- Columbia (located in the USA) who had a histopathological diagnosis of 
      LE. Cases of LE were identified using the pathology reporting system at the 
      University of Missouri Hospital for esophageal biopsy specimens for the 
      above-mentioned period. RESULTS: The data of a total of 20 adult cases with 
      esophageal biopsy specimens consistent with LE were included. CONCLUSION: LE 
      seems to be a benign but disturbing clinical problem and should be remembered in 
      elderly females complaining of dysphagia or refractory reflux symptoms. It has 
      similar endoscopic findings of eosinophilic esophagitis with rings and 
      esophagitis. Smoking and hiatal hernia are common risk factors. The majority of 
      LE patients can respond to proton pump inhibitor (PPI) therapy. Endoscopic 
      dilations and steroid therapy should be considered for PPI nonresponder LE 
      patients.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Yousef, Mohamad
AU  - Yousef M
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, Missouri, Mo, USA.
FAU - Chela, Harleen
AU  - Chela H
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, Missouri, Mo, USA.
FAU - Ertugrul, Hamza
AU  - Ertugrul H
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, Missouri, Mo, USA.
FAU - Albarrak, Abdulmajeed
AU  - Albarrak A
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, Missouri, Mo, USA.
FAU - Basar, Omer
AU  - Basar O
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, Missouri, Mo, USA.
FAU - Pasha, Syed
AU  - Pasha S
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, Missouri, Mo, USA.
FAU - Mousa, Yousef
AU  - Mousa Y
AD  - Department of Pediatrics, Right Way (Germany) Heidekreis-Klinikum GmbH 
      Krankenhaus Walsrode, Walsrode, Germany.
FAU - Al Juboori, Alhareth
AU  - Al Juboori A
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, Missouri, Mo, USA.
FAU - Frazier, Shellaine
AU  - Frazier S
AD  - Department of Pathology, University of Missouri, Columbia, Missouri, Mo, USA.
FAU - Tahan, Veysel
AU  - Tahan V
AUID- ORCID: 0000-0001-6796-9359
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, Missouri, Mo, USA.
FAU - Daglilar, Ebubekir
AU  - Daglilar E
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, Missouri, Mo, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Recent Adv Inflamm Allergy Drug Discov
JT  - Recent advances in inflammation & allergy drug discovery
JID - 101776469
SB  - IM
MH  - Adult
MH  - Female
MH  - Child
MH  - Humans
MH  - Aged
MH  - Retrospective Studies
MH  - *Eosinophilic Esophagitis/diagnosis
MH  - *Deglutition Disorders/epidemiology
MH  - Lymphocytes/pathology
OTO - NOTNLM
OT  - Lymphocytic esophagitis
OT  - dysphagia
OT  - heartburn
OT  - inflammation
OT  - reflux disease
OT  - regurgitation
EDAT- 2023/02/01 06:00
MHDA- 2023/07/28 06:43
CRDT- 2023/01/31 00:53
PHST- 2022/09/15 00:00 [received]
PHST- 2022/12/19 00:00 [revised]
PHST- 2022/12/30 00:00 [accepted]
PHST- 2023/07/28 06:43 [medline]
PHST- 2023/02/01 06:00 [pubmed]
PHST- 2023/01/31 00:53 [entrez]
AID - RAIAD-EPUB-129139 [pii]
AID - 10.2174/2772270817666230130093341 [doi]
PST - ppublish
SO  - Recent Adv Inflamm Allergy Drug Discov. 2023;17(1):79-84. doi: 
      10.2174/2772270817666230130093341.