PMID- 36718225
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 1179-1349 (Print)
IS  - 1179-1349 (Electronic)
IS  - 1179-1349 (Linking)
VI  - 15
DP  - 2023
TI  - Role of Serum Lipids, Blood Glucose and Blood Pressure in Breast Cancer Risk for 
      Women with Type 2 Diabetes Mellitus.
PG  - 109-121
LID - 10.2147/CLEP.S386471 [doi]
AB  - PURPOSE: Women with type 2 diabetes mellitus (T2DM) have an increased risk of 
      breast cancer. We aimed to determine the contribution of lipids, glucose and 
      blood pressure to this risk based on the multifactorial nature of T2DM. PATIENTS 
      AND METHODS: This population-based cohort study used data from a Dutch database 
      (the Groningen Initiative to Analyse Type 2 Diabetes Treatment) for the period 
      2004-2013. The cohort included women diagnosed with T2DM, aged 30-80 years, with 
      no history of breast cancer and with follow-up data for at least 1 year. We used 
      Cox proportional hazards models to estimate the associations of exposures with 
      breast cancer occurrence, reporting adjusted hazard ratios (aHR) with 95% 
      confidence intervals (CI). Exposures of interest included total cholesterol, 
      high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol 
      (LDL-C), triglycerides, glycated hemoglobin A (HbA1c) and systolic blood pressure 
      (SBP). RESULTS: During a median of 4.45 years' follow-up, 183 of 10,183 included 
      women received a breast cancer diagnosis. We observed U-shaped associations with 
      breast cancer incidence for total cholesterol and HDL-C at baseline. Compared 
      with moderate elevations, women had significantly higher breast cancer risks 
      associated with high total cholesterol (aHR, 95% CI: 1.72, 1.15-2.55) and HDL-C 
      (aHR, 95% CI: 1.74, 1.18-2.58) levels, while low total cholesterol (aHR, 95% CI: 
      1.43, 0.94-2.19) and HDL-C (aHR, 95% CI: 1.44, 0.95-2.17) levels produced 
      marginal effects without significance. Women with high LDL-C levels more often 
      received a breast cancer diagnosis than those with medium levels (aHR, 95% CI: 
      1.56, 1.03-2.35). CONCLUSION: This real-world dataset highlights the importance 
      of balancing lipid profiles, particularly total cholesterol and HDL-C. 
      Dysregulation of the lipid profile, not the glucose or blood pressure profiles, 
      may increase the risk of breast cancer in women with T2DM.
CI  - (c) 2023 Zhang et al.
FAU - Zhang, Fan
AU  - Zhang F
AUID- ORCID: 0000-0001-9302-9993
AD  - Department of Epidemiology, University Medical Center Groningen, University of 
      Groningen, Groningen, the Netherlands.
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou, 
      People's Republic of China.
AD  - Oncology Research Laboratory, Cancer Hospital of Shantou University Medical 
      College, Shantou, People's Republic of China.
FAU - de Bock, Geertruida H
AU  - de Bock GH
AUID- ORCID: 0000-0003-3104-4471
AD  - Department of Epidemiology, University Medical Center Groningen, University of 
      Groningen, Groningen, the Netherlands.
FAU - Denig, Petra
AU  - Denig P
AUID- ORCID: 0000-0002-7929-4739
AD  - Department of Clinical Pharmacy and Pharmacology, University Medical Center 
      Groningen, University of Groningen, Groningen, the Netherlands.
FAU - Landman, Gijs W
AU  - Landman GW
AD  - Department of Internal Medicine, Gelre Hospital, Apeldoorn, the Netherlands.
FAU - Zhang, Qingying
AU  - Zhang Q
AUID- ORCID: 0000-0002-4908-4757
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou, 
      People's Republic of China.
FAU - Sidorenkov, Grigory
AU  - Sidorenkov G
AUID- ORCID: 0000-0002-1926-8862
AD  - Department of Epidemiology, University Medical Center Groningen, University of 
      Groningen, Groningen, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20230124
PL  - New Zealand
TA  - Clin Epidemiol
JT  - Clinical epidemiology
JID - 101531700
PMC - PMC9884051
OTO - NOTNLM
OT  - breast cancer
OT  - cholesterol
OT  - glycated hemoglobin A
OT  - systolic blood pressure
OT  - triglycerides
COIS- Fan Zhang received from the Graduate School of Medical Sciences, University of 
      Groningen, University Medical Center Groningen: a PhD position grant. The authors 
      report no other conflicts of interest in this work.
EDAT- 2023/02/01 06:00
MHDA- 2023/02/01 06:01
PMCR- 2023/01/24
CRDT- 2023/01/31 01:45
PHST- 2022/08/16 00:00 [received]
PHST- 2022/12/05 00:00 [accepted]
PHST- 2023/01/31 01:45 [entrez]
PHST- 2023/02/01 06:00 [pubmed]
PHST- 2023/02/01 06:01 [medline]
PHST- 2023/01/24 00:00 [pmc-release]
AID - 386471 [pii]
AID - 10.2147/CLEP.S386471 [doi]
PST - epublish
SO  - Clin Epidemiol. 2023 Jan 24;15:109-121. doi: 10.2147/CLEP.S386471. eCollection 
      2023.