PMID- 36718876
OWN - NLM
STAT- MEDLINE
DCOM- 20230208
LR  - 20231004
IS  - 2047-9980 (Electronic)
IS  - 2047-9980 (Linking)
VI  - 12
IP  - 3
DP  - 2023 Feb 7
TI  - Predictors of Improvement in Exercise Tolerance After Balloon Pulmonary 
      Angioplasty for Chronic Thromboembolic Pulmonary Hypertension.
PG  - e8137
LID - 10.1161/JAHA.122.027395 [doi]
LID - e8137
AB  - Background Balloon pulmonary angioplasty (BPA) improves exercise tolerance and 
      hemodynamic parameters in patients with chronic thromboembolic pulmonary 
      hypertension. However, it is still unclear which patient characteristics 
      contribute to the improvement in exercise tolerance after BPA in chronic 
      thromboembolic pulmonary hypertension. Methods and Results We retrospectively 
      analyzed 126 patients with chronic thromboembolic pulmonary hypertension (aged 
      63+/-14 years; female, 65%) who underwent BPA without concomitant programmed 
      exercise rehabilitation at Keio University between November 2012 and April 2018. 
      Hemodynamic data and 6-minute walk distance (6MWD), as a measure of exercise 
      tolerance, were evaluated before and 1 year after BPA. The clinical 
      characteristics that contributed to improvement in exercise tolerance were 
      elucidated. The 6MWD significantly increased from 372.0 m (256.5-431.3) to 462.0 
      m (378.8-537.0) 1 year after BPA (P<0.001). The improvement rate in the 6MWD 
      after BPA exhibited a good correlation with age, height, mean pulmonary artery 
      pressure, and 6MWD at baseline (Spearman rank correlation coefficients=-0.28, 
      0.24, -0.40, and 0.44, respectively). Additional multivariable linear regression 
      analysis revealed that young age, tall height, high mean pulmonary artery 
      pressure, short 6MWD at baseline, and high lung capacity at baseline were 
      significant predictors of the improvement in 6MWD by BPA (standardized partial 
      regression coefficient -0.39, 0.22, 0.19, -0.62, and 0.25, P<0.001, 0.007, 0.011, 
      <0.001, and <0.001, respectively). Conclusions BPA without concomitant programmed 
      exercise rehabilitation significantly improves exercise tolerance. This was 
      particularly true in young patients with high stature, high mean pulmonary artery 
      pressure, short 6MWD, and lung capacity at the time of diagnosis.
FAU - Daigo, Kyohei
AU  - Daigo K
AUID- ORCID: 0000-0003-2590-8966
AD  - Department of Cardiology Keio University School of Medicine Tokyo Japan.
FAU - Katsumata, Yoshinori
AU  - Katsumata Y
AUID- ORCID: 0000-0001-5576-5789
AD  - Department of Cardiology Keio University School of Medicine Tokyo Japan.
FAU - Esaki, Kosho
AU  - Esaki K
AUID- ORCID: 0000-0003-3830-8265
AD  - Department of Cardiology Keio University School of Medicine Tokyo Japan.
FAU - Iwasawa, Yuji
AU  - Iwasawa Y
AUID- ORCID: 0000-0002-5143-4648
AD  - Department of Cardiology Keio University School of Medicine Tokyo Japan.
FAU - Ichihara, Genki
AU  - Ichihara G
AUID- ORCID: 0000-0002-5580-989X
AD  - Department of Cardiology Keio University School of Medicine Tokyo Japan.
FAU - Miura, Kotaro
AU  - Miura K
AUID- ORCID: 0000-0002-0351-6008
AD  - Department of Cardiology Keio University School of Medicine Tokyo Japan.
FAU - Shirakawa, Kohsuke
AU  - Shirakawa K
AD  - Department of Cardiology Keio University School of Medicine Tokyo Japan.
FAU - Sato, Yasunori
AU  - Sato Y
AD  - Department of Preventive Medicine and Public Health Keio University School of 
      Medicine Tokyo Japan.
FAU - Sato, Kazuki
AU  - Sato K
AUID- ORCID: 0000-0002-0586-1868
AD  - Institute for Integrated Sports Medicine, Keio University School of Medicine 
      Tokyo Japan.
FAU - Fukuda, Keiichi
AU  - Fukuda K
AUID- ORCID: 0000-0003-1413-0482
AD  - Department of Cardiology Keio University School of Medicine Tokyo Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230131
PL  - England
TA  - J Am Heart Assoc
JT  - Journal of the American Heart Association
JID - 101580524
SB  - IM
MH  - Humans
MH  - Female
MH  - *Hypertension, Pulmonary/diagnosis/therapy
MH  - Pulmonary Artery
MH  - *Pulmonary Embolism/diagnosis/therapy/complications
MH  - Exercise Tolerance
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - *Angioplasty, Balloon/adverse effects/methods
MH  - Chronic Disease
PMC - PMC9973625
OTO - NOTNLM
OT  - balloon pulmonary angioplasty
OT  - chronic thromboembolic pulmonary hypertension
OT  - exercise tolerance
EDAT- 2023/02/01 06:00
MHDA- 2023/02/09 06:00
PMCR- 2023/02/07
CRDT- 2023/01/31 06:13
PHST- 2023/02/01 06:00 [pubmed]
PHST- 2023/02/09 06:00 [medline]
PHST- 2023/01/31 06:13 [entrez]
PHST- 2023/02/07 00:00 [pmc-release]
AID - JAH38137 [pii]
AID - 10.1161/JAHA.122.027395 [doi]
PST - ppublish
SO  - J Am Heart Assoc. 2023 Feb 7;12(3):e8137. doi: 10.1161/JAHA.122.027395. Epub 2023 
      Jan 31.