PMID- 36719454
OWN - NLM
STAT- MEDLINE
DCOM- 20231129
LR  - 20231205
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 483
IP  - 5
DP  - 2023 Nov
TI  - A novel EWSR1-MYB fusion in an aggressive advanced breast adenoid cystic 
      carcinoma with mixed classical and solid-basaloid components.
PG  - 717-722
LID - 10.1007/s00428-023-03500-1 [doi]
AB  - Breast adenoid cystic carcinoma (AdCC) with a solid-basaloid component is rare. 
      The solid-basaloid component is usually characterized by solid nests composed of 
      basal-like cells with marked nuclear atypia, high mitotic activity, and necrosis. 
      Given the rarity of such tumors, information on their clinicopathological and 
      genomic characteristics is limited. Herein, we report a case of advanced breast 
      cancer with a poor prognosis with histological and immunohistochemical 
      characteristics of AdCC with a solid-basaloid component. For the solid-basaloid 
      component, fluorescence in situ hybridization (FISH) analysis revealed 
      rearrangement of the EWSR1 and MYB genes, and immunohistochemical staining 
      indicated MYB positivity. Next-generation sequencing-based technology revealed a 
      novel EWSR1-MYB fusion. To our knowledge, this is the first report of an 
      EWSR1-MYB fusion in AdCC with a solid-basaloid component and a poor prognosis. 
      Our findings may extend the genetic understanding of AdCC and aid in the clinical 
      diagnosis of AdCC.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Lei, Ting
AU  - Lei T
AD  - Department of Pathology, The Third Affiliated Hospital of Soochow University, Ju 
      Qian Street 185, Changzhou, 213003, Jiangsu, China.
FAU - Shi, Yongqiang
AU  - Shi Y
AD  - Department of Pathology, The Third Affiliated Hospital of Soochow University, Ju 
      Qian Street 185, Changzhou, 213003, Jiangsu, China.
FAU - Da, Wenyue
AU  - Da W
AD  - Department of Pathology, The Third Affiliated Hospital of Soochow University, Ju 
      Qian Street 185, Changzhou, 213003, Jiangsu, China.
FAU - Xia, Cunyan
AU  - Xia C
AD  - Department of Pathology, The Third Affiliated Hospital of Soochow University, Ju 
      Qian Street 185, Changzhou, 213003, Jiangsu, China.
FAU - Wang, Hui
AU  - Wang H
AUID- ORCID: 0000-0003-2278-9965
AD  - Department of Pathology, The Third Affiliated Hospital of Soochow University, Ju 
      Qian Street 185, Changzhou, 213003, Jiangsu, China. 3wang7hui@163.com.
LA  - eng
GR  - QN202114/Changzhou Science and Technology Bureau/
PT  - Case Reports
PT  - Journal Article
DEP - 20230131
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (EWSR1 protein, human)
RN  - 0 (RNA-Binding Protein EWS)
SB  - IM
MH  - Female
MH  - Humans
MH  - Breast/pathology
MH  - *Breast Neoplasms/pathology
MH  - *Carcinoma, Adenoid Cystic/genetics/pathology
MH  - High-Throughput Nucleotide Sequencing
MH  - In Situ Hybridization, Fluorescence
MH  - RNA-Binding Protein EWS/genetics
OTO - NOTNLM
OT  - Advanced breast adenoid cystic carcinoma
OT  - EWSR1-MYB
OT  - Solid-basaloid components
EDAT- 2023/02/01 06:00
MHDA- 2023/11/27 12:43
CRDT- 2023/01/31 11:14
PHST- 2022/09/27 00:00 [received]
PHST- 2023/01/22 00:00 [accepted]
PHST- 2023/01/19 00:00 [revised]
PHST- 2023/11/27 12:43 [medline]
PHST- 2023/02/01 06:00 [pubmed]
PHST- 2023/01/31 11:14 [entrez]
AID - 10.1007/s00428-023-03500-1 [pii]
AID - 10.1007/s00428-023-03500-1 [doi]
PST - ppublish
SO  - Virchows Arch. 2023 Nov;483(5):717-722. doi: 10.1007/s00428-023-03500-1. Epub 
      2023 Jan 31.