PMID- 36721560
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 12
DP  - 2022 Dec
TI  - Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumors: A Literature 
      Review.
PG  - e33055
LID - 10.7759/cureus.33055 [doi]
LID - e33055
AB  - Histiocytic sarcoma (HS) is a rare tumor that may result from the 
      transdifferentiation of preexisting hematolymphoid neoplasms in a subset of 
      patients. There are instances of correlation or concurrence between HS and a 
      number of cancers, particularly B-cell-associated hematopoietic tumors. Only 
      three cases of HS occurring subsequent to or concurrently with gastrointestinal 
      stromal tumors (GIST) have been recorded. Our main objective was to give an 
      overview of demographics, clinical signs and symptoms, histopathological 
      findings, and immunohistochemical and molecular analysis when HS develops 
      secondary to or concurrently with GIST. A search of PubMed, Google Scholar, and 
      ScienceDirect was undertaken using Medical Subject Headings (MeSH) keywords. 
      According to the findings of our review, there were two males (66.6%) and one 
      female (33.3%). The average age of patients at presentation was 59.6 years. On 
      the immunohistochemistry, three patients were positive for cluster of 
      differentiation (CD) 68 (100%), two patients were positive for CD 163 (67%), one 
      patient was positive for leukocyte common antigen (LCA) (33%), and only one 
      patient was positive for CD 4, CD 10, CD 31, CD 45, human leukocyte antigen 
      (HLA)-DR, lysozyme, and vimentin (33%). On molecular investigation, the gastric 
      mass of only one patient (33.33%) contained a KIT mutation on exon 11. 
      Emperipolesis was observed in one patient (33.33%) on histological examination. 
      Our study provides an important overview of the available literature and gives 
      insight into important diagnostic markers of HS when it occurs secondary to or 
      concurrently with GIST.
CI  - Copyright (c) 2022, Rehman et al.
FAU - Rehman, Shafi
AU  - Rehman S
AD  - Pathology, Shifa College of Medical Technology, Shifa Tameer-E-Millat University, 
      Islamabad, PAK.
FAU - Iqbal, Rashid
AU  - Iqbal R
AD  - Medical Biochemistry, Shifa College of Medical Technology, Shifa Tameer-E-Millat 
      University, Islamabad, PAK.
FAU - Sukaina, Mahnoor
AU  - Sukaina M
AD  - Medicine, Karachi Medical and Dental College, Karachi, PAK.
FAU - Shaik Masthan, Shameera
AU  - Shaik Masthan S
AD  - Medicine, University of Louisville, Louisville, USA.
FAU - Bint I Munir, Amna
AU  - Bint I Munir A
AD  - Medicine, Fatima Jinnah Medical University, Lahore, PAK.
FAU - Iqbal, Yagana
AU  - Iqbal Y
AD  - Internal Medicine, Allama Iqbal Medical College, lahore, PAK.
FAU - Qureshi, Muhammad H
AU  - Qureshi MH
AD  - Internal Medicine, Mayo Hospital, Lahore, PAK.
FAU - Husnain, Ali
AU  - Husnain A
AD  - Medicine, Mayo Hospital, Lahore, PAK.
FAU - Ghafoor, Sana
AU  - Ghafoor S
AD  - Internal Medicine, Shalimar Clinic, Islamabad, PAK.
FAU - Ghafoor, Bushra
AU  - Ghafoor B
AD  - Research, University of Texas Southwestern Medical Center, Dallas, USA.
AD  - Medicine, Dera Ghazi Khan Medical College, Dera Ghazi Khan, PAK.
AD  - Internal Medicine, Nishtar Medical University, Multan, PAK.
FAU - Nagarajan, Jai S
AU  - Nagarajan JS
AD  - Medicine, Sri Ramaswamy Memorial (SRM) Medical College Hospital and Research 
      Centre, Chennai, IND.
FAU - Pervaiz, Fariyal
AU  - Pervaiz F
AD  - Anatomy, Radiology, Cardiac Catheterization, Shifa College of Medical Technology, 
      Shifa Tameer-E-Millat University, Islamabad, PAK.
FAU - Haseeb Ul Rasool, Muhammad
AU  - Haseeb Ul Rasool M
AD  - Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New 
      York City, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221228
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9882698
OTO - NOTNLM
OT  - case reports
OT  - coexistence
OT  - gastrointestinal stromal tumors (gists)
OT  - histiocytic sarcoma
OT  - rare disease
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/02/02 06:00
MHDA- 2023/02/02 06:01
PMCR- 2022/12/28
CRDT- 2023/02/01 01:47
PHST- 2022/12/28 00:00 [accepted]
PHST- 2023/02/01 01:47 [entrez]
PHST- 2023/02/02 06:00 [pubmed]
PHST- 2023/02/02 06:01 [medline]
PHST- 2022/12/28 00:00 [pmc-release]
AID - 10.7759/cureus.33055 [doi]
PST - epublish
SO  - Cureus. 2022 Dec 28;14(12):e33055. doi: 10.7759/cureus.33055. eCollection 2022 
      Dec.