PMID- 36724583
OWN - NLM
STAT- MEDLINE
DCOM- 20230911
LR  - 20230911
IS  - 1769-7131 (Electronic)
IS  - 0987-7053 (Linking)
VI  - 53
IP  - 3
DP  - 2023 Jun
TI  - Multimodal integration and modulation of visual and somatosensory inputs on the 
      corticospinal excitability.
PG  - 102842
LID - S0987-7053(22)00126-5 [pii]
LID - 10.1016/j.neucli.2022.102842 [doi]
AB  - OBJECTIVE: Corticospinal excitability may be affected by various sensory inputs 
      under physiological conditions. In this study, we aimed to investigate the 
      corticospinal excitability by using multimodal conditioning paradigms of combined 
      somatosensory electrical and visual stimulation to understand the sensory-motor 
      integration. METHODS: We examined motor evoked potentials (MEP) obtained by using 
      transcranial magnetic stimulation (TMS) that were conditioned by using a single 
      goggle-light-emitting diode (LED) stimulation, peripheral nerve electrical 
      stimulation (short latency afferent inhibition protocol), or a combination of 
      both (goggle-LED+electrical stimulation) at different interstimulus intervals 
      (ISIs) in 14 healthy volunteers. RESULTS: We found MEP inhibition at ISIs of 
      50-60 ms using the conditioned goggle-LED stimulation. The combined goggle-LED 
      stimulation at a 60 ms ISI resulted in an additional inhibition to the electrical 
      stimulation. CONCLUSIONS: Visual inputs cause significant modulatory effects on 
      the corticospinal excitability. Combined visual and somatosensory stimuli 
      integrate probably via different neural circuits and/or interneuron populations. 
      To our knowledge, multimodal integration of visual and somatosensory inputs by 
      using TMS-short latency inhibition protocol have been evaluated via 
      electrophysiological methods for the first time in this study.
CI  - Copyright (c) 2022 Elsevier Masson SAS. All rights reserved.
FAU - Yildiz, Fatma Gokcem
AU  - Yildiz FG
AD  - Faculty of Medicine, Department of Neurology, Hacettepe Univesity, EMG-TMS Unit, 
      Ankara, Turkey; Hacettepe University, Institute of Neurological Sciences and 
      Psychiatry, Ankara, Turkey. Electronic address: gokcemyildiz@hotmail.com.
FAU - Temucin, Cagri Mesut
AU  - Temucin CM
AD  - Faculty of Medicine, Department of Neurology, Hacettepe Univesity, EMG-TMS Unit, 
      Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20230131
PL  - France
TA  - Neurophysiol Clin
JT  - Neurophysiologie clinique = Clinical neurophysiology
JID - 8804532
SB  - IM
MH  - Humans
MH  - *Evoked Potentials, Motor/physiology
MH  - Electric Stimulation/methods
MH  - Reaction Time/physiology
MH  - Time
MH  - *Transcranial Magnetic Stimulation/methods
MH  - Neural Inhibition/physiology
MH  - Muscle, Skeletal/physiology
OTO - NOTNLM
OT  - Goggle LED
OT  - Multimodal integration
OT  - Short latency afferent inhibition
OT  - Transcranial magnetic stimulation
OT  - Visual cortex
COIS- Declaration of Competing Interest None of the authors has any direct or indirect 
      conflicts of interest.
EDAT- 2023/02/02 06:00
MHDA- 2023/09/11 06:42
CRDT- 2023/02/01 18:08
PHST- 2022/06/20 00:00 [received]
PHST- 2022/12/06 00:00 [revised]
PHST- 2022/12/17 00:00 [accepted]
PHST- 2023/09/11 06:42 [medline]
PHST- 2023/02/02 06:00 [pubmed]
PHST- 2023/02/01 18:08 [entrez]
AID - S0987-7053(22)00126-5 [pii]
AID - 10.1016/j.neucli.2022.102842 [doi]
PST - ppublish
SO  - Neurophysiol Clin. 2023 Jun;53(3):102842. doi: 10.1016/j.neucli.2022.102842. Epub 
      2023 Jan 31.