PMID- 3672524
OWN - NLM
STAT- MEDLINE
DCOM- 19871211
LR  - 20190727
IS  - 0041-008X (Print)
IS  - 0041-008X (Linking)
VI  - 91
IP  - 2
DP  - 1987 Nov
TI  - Teratogenic effects of polychlorinated dibenzofurans in combination in C57BL/6N 
      mice.
PG  - 246-55
AB  - Polychlorinated dibenzofurans (PCDFs) are highly toxic environmental contaminants 
      which have been involved in several incidents of human poisoning. Two congeners, 
      2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF) and 
      1,2,3,4,7,8-hexachlorodibenzofuran (HCDF), have been shown to persist in the 
      tissues of victims of accidental ingestion from Japan and Taiwan. The 
      teratogenicity of these compounds, both alone and in combination, was assessed in 
      C57BL/6N mice. Pregnant mice were treated with 10 ml/kg corn oil containing no 
      PCDFs, 4-PeCDF (0-30 micrograms/kg), HCDF (0-300 micrograms/kg), or a combination 
      of the two on gestation Days 10-13, followed by necropsy on gestation Day 18. 
      Maternal and fetal toxicity were assessed and selected soft tissues were examined 
      for abnormalities. Both chemicals caused hydronephrosis and cleft palate in the 
      absence of any overt toxicity. Hydronephrosis occurred at doses approximately 
      fivefold lower than those causing cleft palate. The combination of 4-PeCDF and 
      HCDF was additive for terata based on responses predicted by probit analysis. In 
      addition, the combination of 2,3,4,5,3',4'-hexachlorobiphenyl (0-60 mg/kg), a 
      structurally related compound also present in PCDF poisoning victims, and 4-PeCDF 
      appears additive. Thus, these chemicals, which cause toxic effects similar to 
      those of 2,3,7,8-tetrachlorodibenzo-p-dioxin, are additive in the induction of 
      fetal anomalies in the mouse.
FAU - Birnbaum, L S
AU  - Birnbaum LS
AD  - Systemic Toxicology Branch, National Institute of Environmental Health Sciences, 
      Research Triangle Park, North Carolina 27709.
FAU - Harris, M W
AU  - Harris MW
FAU - Crawford, D D
AU  - Crawford DD
FAU - Morrissey, R E
AU  - Morrissey RE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Benzofurans)
RN  - 0 (Polymers)
RN  - 0 (Teratogens)
RN  - 0 (polychlorodibenzofuran)
SB  - IM
MH  - Animals
MH  - Benzofurans/*toxicity
MH  - Body Weight/drug effects
MH  - Cleft Palate/chemically induced
MH  - Female
MH  - Fetal Death
MH  - Fetus/drug effects
MH  - Hydronephrosis/chemically induced
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Polymers
MH  - Pregnancy
MH  - Structure-Activity Relationship
MH  - *Teratogens
EDAT- 1987/11/01 00:00
MHDA- 1987/11/01 00:01
CRDT- 1987/11/01 00:00
PHST- 1987/11/01 00:00 [pubmed]
PHST- 1987/11/01 00:01 [medline]
PHST- 1987/11/01 00:00 [entrez]
AID - 0041-008X(87)90105-0 [pii]
AID - 10.1016/0041-008x(87)90105-0 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 1987 Nov;91(2):246-55. doi: 10.1016/0041-008x(87)90105-0.