PMID- 36725293
OWN - NLM
STAT- MEDLINE
DCOM- 20230206
LR  - 20230206
IS  - 1001-9391 (Print)
IS  - 1001-9391 (Linking)
VI  - 41
IP  - 1
DP  - 2023 Jan 20
TI  - [Effect of transcranial direct current stimulation on neurological injury markers 
      and prognosis in patients with acute and severe carbon monoxide poisoning].
PG  - 39-43
LID - 10.3760/cma.j.cn121094-20211027-00522 [doi]
AB  - Objective: To observe the effects of transcranial direct current stimulation 
      (tDCS) on nerve injury markers and prognosis in patients with acute severe carbon 
      monoxide poisoning (ASCOP) . Methods: In May 2021, 103 ASCOP patients were 
      treated in the emergency department of Harrison International Peace Hospital of 
      Hebei Medical University from November 2020 to January 2021. The patients were 
      divided into two groups according to whether they received tDCS treatment. The 
      control group (50 cases) were given oxygen therapy (hyperbaric oxygen and oxygen 
      inhalation) , reducing cranial pressure, improving brain circulation and cell 
      metabolism, removing oxygen free radicals and symptomatic support, and the 
      observation group (53 cases) was treated with 2 weeks of tDCS intensive treatment 
      on the basis of conventional treatment. All patients underwent at least 24 h 
      bispectral index (BIS) monitoring, BIS value was recorded at the hour and the 24 
      h mean value was calculated. Neuron-specific enolase (NSE) and serum S100B 
      calcium-binding protein (S100B) were detected after admission, 3 d, 7 d and 
      discharge. Follow-up for 60 days, the incidence and time of onset of delayed 
      encephalopathy (DEACMP) with acute carbon monoxide poisoning in the two groups 
      were recorded. Results: The NSE and S100B proteins of ASCOP patients were 
      significantly increased at admission, but there was no significant difference 
      between the two groups (P=0.711, 0.326) . The NSE and S100B proteins were further 
      increased at 3 and 7 days after admission. The increase in the observation group 
      was slower than that in the control group, and the difference was statistically 
      significant (P(3 d)=0.045, 0.032, P(7 d)=0.021, 0.000) ; After 14 days, it 
      gradually decreased, but the observation group decreased rapidly compared with 
      the control group, with a statistically significant difference (P=0.009, 0.025) . 
      The 60 day follow-up results showed that the incidence of DEACMP in the 
      observation group was 18.87% (10/53) , compared with 38.00% (19/50) in the 
      control group (P=0.048) ; The time of DEACMP in the observation group[ 
      (16.79+/-5.28) d] was later than that in the control group[ (22.30+/-5.42) d], and 
      the difference was statistically significant (P=0.013) . Conclusion: The early 
      administration of tDCS in ASCOP patients can prevent the production of NSE and 
      S100B proteins, which are markers of nerve damage. and can improve the incidence 
      and time of DEACMP.
FAU - Du, Y R
AU  - Du YR
AD  - Department of Rehabilitation Medicine, Harrison International Peace Hospital 
      Affiliated to Hebei Medical University, Hengshui 053000, China.
FAU - Du, Y X
AU  - Du YX
AD  - Emergency Department, Harrison International Peace Hospital Affiliated to Hebei 
      Medical University, Hengshui 053000, China.
FAU - Wang, P
AU  - Wang P
AD  - Emergency Department, Harrison International Peace Hospital Affiliated to Hebei 
      Medical University, Hengshui 053000, China.
FAU - Wang, W Z
AU  - Wang WZ
AD  - Emergency Department, Harrison International Peace Hospital Affiliated to Hebei 
      Medical University, Hengshui 053000, China.
LA  - chi
GR  - 2020014032Z/Hengshui Municipal Science and Technology Plan Self-funded Project/
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
JT  - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng 
      zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
JID - 8410840
RN  - 0 (Biomarkers)
RN  - S88TT14065 (Oxygen)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
SB  - IM
MH  - Humans
MH  - Biomarkers
MH  - *Brain Diseases/etiology/therapy
MH  - *Carbon Monoxide Poisoning/complications/therapy
MH  - Oxygen
MH  - Phosphopyruvate Hydratase
MH  - Prognosis
MH  - S100 Calcium Binding Protein beta Subunit
MH  - *Transcranial Direct Current Stimulation
OTO - NOTNLM
OT  - Acute
OT  - Neuron-specific enolase
OT  - Prognosis
OT  - S100B protein
OT  - Severe carbon monoxide poisoning
OT  - Transcranial direct current stimulation
EDAT- 2023/02/02 06:00
MHDA- 2023/02/04 06:00
CRDT- 2023/02/01 21:20
PHST- 2023/02/01 21:20 [entrez]
PHST- 2023/02/02 06:00 [pubmed]
PHST- 2023/02/04 06:00 [medline]
AID - 10.3760/cma.j.cn121094-20211027-00522 [doi]
PST - ppublish
SO  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2023 Jan 20;41(1):39-43. doi: 
      10.3760/cma.j.cn121094-20211027-00522.