PMID- 36725456
OWN - NLM
STAT- MEDLINE
DCOM- 20230303
LR  - 20230303
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 84
IP  - 3
DP  - 2023 Mar
TI  - Next-generation sequencing-based HLA typing reveals the association of 
      HLA-B*46:01:01 and HLA-DRB1*09:01:02 alleles with carbamazepine-induced 
      hypersensitivity reactions in Vietnamese patients with epilepsy.
PG  - 186-195
LID - S0198-8859(23)00005-8 [pii]
LID - 10.1016/j.humimm.2023.01.005 [doi]
AB  - Several studies have reported an association between certain human leukocyte 
      antigen (HLA) alleles and carbamazepine (CBZ)-induced hypersensitivity reactions 
      in patients with epilepsy. Here, the relationship between the clinical spectrum 
      and the HLA allele profiles in patients with CBZ-induced hypersensitivity 
      reactions was investigated using next-generation sequence (NGS) data obtained 
      from 65 Vietnamese patients with epilepsy, including 33 with CBZ-tolerance and 32 
      patients with CBZ-hypersensitivity, in which only 8 with severe cutaneous adverse 
      drug reactions and 24 were mild-hypersensitive patients. Three loci of HLA class 
      I (HLA-A, -B, and -C) and two loci of HLA class II (HLA-DQA1 and -DRB1) were 
      included in our analysis. We observed a higher prevalence of three alleles, 
      HLA-B*46:01:01, HLA-DQA1*03:02:01, and HLA-DRB1*09:01:02, in the CBZ 
      hypersensitivity group compared to that in the CBZ tolerant group. Notably, all 
      hypersensitive patients with HLA-DQA1*03:02:01 also harbored HLA-DRB1*09:01:02. 
      We also used molecular modeling to gain mechanistic insight into the interactions 
      of HLA-B*46:01 and HLA-DRB1*09:01 with CBZ. Our findings proposed the direct 
      interaction of CBZ with peptide-binding pockets of these HLA proteins. The 
      sensitivity and specificity of HLA-B*46:01:01 in considering with the appearance 
      of HLA-DRB1*09:01:02 were 46.88% and 84.85%, respectively. Our data suggest that 
      the presence of HLA-B*46:01:01/HLA-DRB1*09:01:02 is a potential marker of 
      CBZ-induced hypersensitivity reactions in Vietnamese patients.
CI  - Copyright (c) 2023 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Bui, Thao Phuong
AU  - Bui TP
AD  - Key Laboratory of Enzyme and Protein Technology, VNU University of Science, 
      Vietnam National University, Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Viet Nam; 
      Department of Biology, VNU University of Science, Vietnam National University, 
      Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Viet Nam.
FAU - Nguyen, Linh Thi Tu
AU  - Nguyen LTT
AD  - Key Laboratory of Enzyme and Protein Technology, VNU University of Science, 
      Vietnam National University, Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Viet Nam; 
      Department of Biology, VNU University of Science, Vietnam National University, 
      Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Viet Nam.
FAU - Le, Phuong Lan
AU  - Le PL
AD  - Department of Biology, VNU University of Science, Vietnam National University, 
      Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Viet Nam.
FAU - Le, Nhan Thi Thanh
AU  - Le NTT
AD  - Key Laboratory of Enzyme and Protein Technology, VNU University of Science, 
      Vietnam National University, Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Viet Nam.
FAU - Nguyen, Thuy Doan
AU  - Nguyen TD
AD  - Department of Neuroscience, Hanoi Medical University, 1 Ton That Tung, Dong Da, 
      Hanoi, Viet Nam; Department of Neurology & Stroke, Tam Anh General Hospital, 108 
      Hoang Nhu Tiep, Bo De, Long Bien, Hanoi, Viet Nam.
FAU - Van Nguyen, Lieu
AU  - Van Nguyen L
AD  - Department of Neuroscience, Hanoi Medical University, 1 Ton That Tung, Dong Da, 
      Hanoi, Viet Nam; Department of Neurology & Stroke, Tam Anh General Hospital, 108 
      Hoang Nhu Tiep, Bo De, Long Bien, Hanoi, Viet Nam.
FAU - Van Nguyen, Anh Thi
AU  - Van Nguyen AT
AD  - Key Laboratory of Enzyme and Protein Technology, VNU University of Science, 
      Vietnam National University, Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Viet Nam.
FAU - Trinh, Thai Hong
AU  - Trinh TH
AD  - Key Laboratory of Enzyme and Protein Technology, VNU University of Science, 
      Vietnam National University, Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Viet Nam; 
      Department of Biology, VNU University of Science, Vietnam National University, 
      Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Viet Nam. Electronic address: 
      thaith@vnu.edu.vn.
LA  - eng
PT  - Journal Article
DEP - 20230131
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Anticonvulsants)
RN  - 33CM23913M (Carbamazepine)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*09:01:02 antigen)
SB  - IM
MH  - Humans
MH  - Alleles
MH  - Anticonvulsants/adverse effects
MH  - *Carbamazepine/adverse effects
MH  - *Drug Hypersensitivity/genetics
MH  - *Epilepsy/drug therapy
MH  - High-Throughput Nucleotide Sequencing
MH  - Histocompatibility Testing
MH  - *HLA-B Antigens/genetics
MH  - *HLA-DRB1 Chains/genetics
MH  - Southeast Asian People
OTO - NOTNLM
OT  - Carbamazepine
OT  - Epilepsy
OT  - HLA-B*46:01:01
OT  - HLA-DRB1*09:01:02
OT  - Hypersensitivity
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/02/02 06:00
MHDA- 2023/03/04 06:00
CRDT- 2023/02/01 22:03
PHST- 2022/06/15 00:00 [received]
PHST- 2022/11/03 00:00 [revised]
PHST- 2023/01/17 00:00 [accepted]
PHST- 2023/02/02 06:00 [pubmed]
PHST- 2023/03/04 06:00 [medline]
PHST- 2023/02/01 22:03 [entrez]
AID - S0198-8859(23)00005-8 [pii]
AID - 10.1016/j.humimm.2023.01.005 [doi]
PST - ppublish
SO  - Hum Immunol. 2023 Mar;84(3):186-195. doi: 10.1016/j.humimm.2023.01.005. Epub 2023 
      Jan 31.