PMID- 36726012
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230829
IS  - 2058-7716 (Print)
IS  - 2058-7716 (Electronic)
IS  - 2058-7716 (Linking)
VI  - 9
IP  - 1
DP  - 2023 Feb 2
TI  - ERCC6L facilitates the progression of laryngeal squamous cell carcinoma by the 
      binding of FOXM1 and KIF4A.
PG  - 41
LID - 10.1038/s41420-023-01314-3 [doi]
LID - 41
AB  - The role of excision repair cross-complementation group 6-like (ERCC6L) has been 
      reported in several cancers, but little is known about its expression and 
      function in laryngeal squamous cell carcinoma (LSCC). In this study, the 
      expression of ERCC6L in LSCC was determined by immunohistochemistry and its 
      correlation with prognostic factors was analyzed. Furthermore, cytological 
      functional validation elucidated the role and underlying mechanisms of ERCC6L 
      dysregulation in LSCC. Our data revealed that ERCC6L expression was elevated in 
      LSCC and it's correlated with TNM stage. In addition, ERCC6L knockdown LSCC cells 
      showed decreased proliferation and migration, increased apoptosis, and reactive 
      oxygen species (ROS). Mechanically, overexpression of ERCC6L promoted nuclear 
      translocation of FOXM1 to facilitate direct binding to the KIF4A promoter and 
      upregulated KIF4A expression. Furthermore, KIF4A knockdown attenuated the role of 
      ERCC6L overexpression in promoting proliferation, migration, and tumorigenesis of 
      LSCC cells. In summary, ERCC6L promoted the binding of FOXM1 and KIF4A in LSCC 
      cells to drive their progression, which may be a promising target for precision 
      therapy in this disease.
CI  - (c) 2023. The Author(s).
FAU - Cui, Meng
AU  - Cui M
AD  - Department of Head and Neck Thyroid, The Affiliated Cancer Hospital of Zhengzhou 
      University & Henan Cancer Hospital, 127 Dongming Road, Zhengzhou, 450008, 
      People's Republic of China.
FAU - Chang, Yu
AU  - Chang Y
AD  - Department of Oncology, The First Affiliated Hospital of Zhengzhou University, 1 
      Jianshe Dong Road, Zhengzhou, 450007, People's Republic of China.
FAU - Wang, Jiheng
AU  - Wang J
AD  - Department of Head and Neck Thyroid, The Affiliated Cancer Hospital of Zhengzhou 
      University & Henan Cancer Hospital, 127 Dongming Road, Zhengzhou, 450008, 
      People's Republic of China.
FAU - Wu, Junfu
AU  - Wu J
AD  - Department of Head and Neck Thyroid, The Affiliated Cancer Hospital of Zhengzhou 
      University & Henan Cancer Hospital, 127 Dongming Road, Zhengzhou, 450008, 
      People's Republic of China.
FAU - Li, Gang
AU  - Li G
AD  - Department of Head and Neck Thyroid, The Affiliated Cancer Hospital of Zhengzhou 
      University & Henan Cancer Hospital, 127 Dongming Road, Zhengzhou, 450008, 
      People's Republic of China.
FAU - Tan, Jie
AU  - Tan J
AUID- ORCID: 0000-0002-3011-7715
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Peking University 
      People's Hospital, Peking University, Xi Zhi Men South Street 11, Western 
      District, Beijing, 100034, P.R. China. feie1980@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230202
PL  - United States
TA  - Cell Death Discov
JT  - Cell death discovery
JID - 101665035
EIN - Cell Death Discov. 2023 Aug 29;9(1):322. PMID: 37644015
PMC - PMC9892579
COIS- The authors declare no competing interests.
EDAT- 2023/02/03 06:00
MHDA- 2023/02/03 06:01
PMCR- 2023/02/02
CRDT- 2023/02/02 00:00
PHST- 2022/09/28 00:00 [received]
PHST- 2023/01/09 00:00 [accepted]
PHST- 2023/01/04 00:00 [revised]
PHST- 2023/02/02 00:00 [entrez]
PHST- 2023/02/03 06:00 [pubmed]
PHST- 2023/02/03 06:01 [medline]
PHST- 2023/02/02 00:00 [pmc-release]
AID - 10.1038/s41420-023-01314-3 [pii]
AID - 1314 [pii]
AID - 10.1038/s41420-023-01314-3 [doi]
PST - epublish
SO  - Cell Death Discov. 2023 Feb 2;9(1):41. doi: 10.1038/s41420-023-01314-3.