PMID- 36726181 OWN - NLM STAT- MEDLINE DCOM- 20230203 LR - 20230204 IS - 1475-2875 (Electronic) IS - 1475-2875 (Linking) VI - 22 IP - 1 DP - 2023 Feb 1 TI - Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo. PG - 35 LID - 10.1186/s12936-023-04458-w [doi] LID - 35 AB - BACKGROUND: Malaria morbidity and mortality increase in the Democratic Republic of the Congo (DRC) may be the consequence of the low utilization rate of long-lasting insecticidal nets (LLINs) resulting from poor compliance due to adverse events (AEs). This study aimed at determining the prevalence and predictors of AEs following the mass distribution of LLINs in the Kisantu Health Zone (KHZ), a high malaria-endemic region in the DRC. METHODS: A community-based cross-sectional study embedded was conducted within a randomized controlled trial (RCT) after the mass distribution of LLINs in 30 villages located in DRC KHZ. A three-stage sampling method was used without replacement to select 1790 children. Data was collected on adverse events (AEs) using a reporting form and information on demographics, nutritional status, and house characteristics. This was done using a structured questionnaire administered to household heads. Logistic regression models were used to identify predictors of AEs following the mass distribution of LLINs. RESULT: In a total of 1790 children enrolled, 17.8% (95% CI 16.1-19.7) experienced AEs. The most common AEs were respiratory-related (61%). Around 60% of AEs occurred within 24 h of use, and 51% were resolved without treatment. Sleeping under deltamethrin LLINs (Adjusted OR, 95% CI 5.5 [3.8-8.0]) and zinc roofing (Adjusted OR, 95% CI 1.98 [1.1-3.57]) were associated with the risk of reporting an AE following the mass distribution of LLINs. CONCLUSION: Approximately 1 out of 5 children had an AE within 24 h following LLIN use. These adverse events were often respiratory-related. LLINs and roofing types were associated with a higher risk of reporting AEs. However, further research using a robust study design is needed to confirm these findings. Future studies should design and implement interventions aiming to reduce AEs and improve compliance with LLINs. CI - (c) 2023. The Author(s). FAU - Ilombe, Gillon AU - Ilombe G AD - Unit of Entomology, Department of Parasitology, National Institute of Biomedical Research, Kinshasa, Democratic Republic of the Congo. gillonilombe@yahoo.fr. AD - Unit of Clinical Pharmacology and Pharmacovigilance, Department of Base Science, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo. gillonilombe@yahoo.fr. AD - Faculty of Medicine, Global Health Institute, Antwerp University, Antwerp, Belgium. gillonilombe@yahoo.fr. FAU - Mpiempie, Therese AU - Mpiempie T AD - Unit of Clinical Pharmacology and Pharmacovigilance, Department of Base Science, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo. FAU - Mesia, Gauthier AU - Mesia G AD - Unit of Clinical Pharmacology and Pharmacovigilance, Department of Base Science, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo. FAU - Matangila, Junior R AU - Matangila JR AD - Department of Tropical Medicine, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo. FAU - Lulebo, Aimee M AU - Lulebo AM AD - Faculty of Medicine, Public Health School, University of Kinshasa, Kinshasa, Democratic Republic of the Congo. FAU - Maketa, Vivi AU - Maketa V AD - Department of Tropical Medicine, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo. FAU - Mabanzila, Baby AU - Mabanzila B AD - Department of Tropical Medicine, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo. FAU - Muela, Nicole M AU - Muela NM AD - Expanded on Inoculation Logistic Section, Ministry of Public Health Kinshasa, Kinshasa, Democratic Republic of the Congo. FAU - Muanda, Flory T AU - Muanda FT AD - Unit of Clinical Pharmacology and Pharmacovigilance, Department of Base Science, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo. AD - ICES, Toronto, ON, Canada. AD - Department of Physiology and Pharmacology, Western University, London, Ontario, Canada. FAU - Linsuke, Sylvie AU - Linsuke S AD - Faculty of Medicine, Global Health Institute, Antwerp University, Antwerp, Belgium. AD - Department of Epidemiology, National Institute of Biomedical Research, Kinshasa, Democratic Republic of the Congo. FAU - van Geertruyden, Jean-Pierre AU - van Geertruyden JP AD - Faculty of Medicine, Global Health Institute, Antwerp University, Antwerp, Belgium. FAU - Lutumba, Pascal AU - Lutumba P AD - Department of Tropical Medicine, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20230201 PL - England TA - Malar J JT - Malaria journal JID - 101139802 RN - 0 (Insecticides) SB - IM MH - Child MH - Humans MH - *Insecticides/adverse effects MH - Democratic Republic of the Congo/epidemiology MH - Prevalence MH - Cross-Sectional Studies MH - *Insecticide-Treated Bednets MH - *Malaria/prevention & control/epidemiology MH - Mosquito Control/methods PMC - PMC9893672 COIS- All authors declare that they have no competing interests. EDAT- 2023/02/03 06:00 MHDA- 2023/02/04 06:00 PMCR- 2023/02/01 CRDT- 2023/02/02 00:12 PHST- 2022/05/04 00:00 [received] PHST- 2023/01/16 00:00 [accepted] PHST- 2023/02/02 00:12 [entrez] PHST- 2023/02/03 06:00 [pubmed] PHST- 2023/02/04 06:00 [medline] PHST- 2023/02/01 00:00 [pmc-release] AID - 10.1186/s12936-023-04458-w [pii] AID - 4458 [pii] AID - 10.1186/s12936-023-04458-w [doi] PST - epublish SO - Malar J. 2023 Feb 1;22(1):35. doi: 10.1186/s12936-023-04458-w.