PMID- 36727029
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230203
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Mechanism of homocysteine-mediated endothelial injury and its consequences for 
      atherosclerosis.
PG  - 1109445
LID - 10.3389/fcvm.2022.1109445 [doi]
LID - 1109445
AB  - Homocysteine (Hcy) is an intermediate amino acid formed during the conversion 
      from methionine to cysteine. When the fasting plasma Hcy level is higher than 15 
      mumol/L, it is considered as hyperhomocysteinemia (HHcy). The vascular endothelium 
      is an important barrier to vascular homeostasis, and its impairment is the 
      initiation of atherosclerosis (AS). HHcy is an important risk factor for AS, 
      which can promote the development of AS and the occurrence of cardiovascular 
      events, and Hcy damage to the endothelium is considered to play a very important 
      role. However, the mechanism by which Hcy damages the endothelium is still not 
      fully understood. This review summarizes the mechanism of Hcy-induced endothelial 
      injury and the treatment methods to alleviate the Hcy induced endothelial 
      dysfunction, in order to provide new thoughts for the diagnosis and treatment of 
      Hcy-induced endothelial injury and subsequent AS-related diseases.
CI  - Copyright (c) 2023 Yuan, Chu, Lin, Zhu, Qian, Yu, Yao, Ping, Chen and Liu.
FAU - Yuan, Deqiang
AU  - Yuan D
AD  - Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, China.
FAU - Chu, Jiapeng
AU  - Chu J
AD  - Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, China.
FAU - Lin, Hao
AU  - Lin H
AD  - Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, China.
FAU - Zhu, Guoqi
AU  - Zhu G
AD  - Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, China.
FAU - Qian, Jun
AU  - Qian J
AD  - Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, China.
FAU - Yu, Yunan
AU  - Yu Y
AD  - Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, China.
FAU - Yao, Tongqing
AU  - Yao T
AD  - Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, China.
FAU - Ping, Fan
AU  - Ping F
AD  - Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, China.
FAU - Chen, Fei
AU  - Chen F
AD  - Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, China.
FAU - Liu, Xuebo
AU  - Liu X
AD  - Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230116
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9884709
OTO - NOTNLM
OT  - atherosclerosis
OT  - endothelial cells
OT  - homocysteine
OT  - hyperhomocysteinemia
OT  - inflammation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/02/03 06:00
MHDA- 2023/02/03 06:01
PMCR- 2022/01/01
CRDT- 2023/02/02 02:05
PHST- 2022/11/27 00:00 [received]
PHST- 2022/12/28 00:00 [accepted]
PHST- 2023/02/02 02:05 [entrez]
PHST- 2023/02/03 06:00 [pubmed]
PHST- 2023/02/03 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.1109445 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2023 Jan 16;9:1109445. doi: 10.3389/fcvm.2022.1109445. 
      eCollection 2022.