PMID- 36727809
OWN - NLM
STAT- MEDLINE
DCOM- 20230515
LR  - 20230830
IS  - 1537-2677 (Electronic)
IS  - 0740-9303 (Linking)
VI  - 39
IP  - 3
DP  - 2023 May-Jun 01
TI  - Effect of Multimodal Preemptive Analgesia of Flurbiprofen Axetil, Nalbuphine, and 
      Retrobulbar Block on Postoperative Pain and Enhanced Recovery in Patients 
      Undergoing Oculoplastic Day Surgery: A Prospective, Randomized, Double-Blinded 
      Study.
PG  - 260-265
LID - 10.1097/IOP.0000000000002308 [doi]
AB  - PURPOSE: To evaluate the effect of either flurbiprofen axetil or nalbuphine 
      combined with retrobulbar block (RB) before surgery on postoperative pain control 
      and enhanced recovery in day-care patients undergoing orbital implantation. 
      METHODS: A total of 45 patients undergoing orbital implantation with general 
      anesthesia were randomly divided into three groups: flurbiprofen axetil (1 mg/kg) 
      combined with RB (group F), nalbuphine (0.1 mg/kg) combined with RB (group N), 
      and placebo as normal saline with RB (group C). The primary outcome was the 
      average pain score (numeric rating scale: 0-10) within the first 24 hours. Other 
      outcomes including the peak pain score, paracetamol requirement, quality of 
      recovery (QoR)-15, and adverse effects (AEs) were assessed. RESULTS: The average 
      and peak pain scores within 24 hours after surgery in group F were significantly 
      lower than in other groups ( p < 0.0167). Compared with group C, the NRS scores 
      were significantly decreased at 2 and 4 hours in group F, and 2 hours in group N 
      after surgery ( p < 0.0167), but without significant differences at other 
      measured time points. The time to first paracetamol oral intake displayed a 
      significant difference among the three groups ( p < 0.0167). CONCLUSION: 
      Preemptive use of flurbiprofen axetil 1 mg/kg combined with RB is an optimal 
      choice for multimodal analgesia for day-care patients undergoing orbital 
      implantation in terms of efficient acute pain control, without impeding 
      patient-enhanced recovery.
CI  - Copyright (c) 2023 The American Society of Ophthalmic Plastic and Reconstructive 
      Surgery, Inc.
FAU - Ye, Zexi
AU  - Ye Z
AD  - Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen 
      University, Guangzhou 510060, China.
AD  - Department of Anesthesiology, State Key Laboratory of Ophthalmology, Zhongshan 
      Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
FAU - Zhu, Yanling
AU  - Zhu Y
AD  - Department of Anesthesiology, State Key Laboratory of Ophthalmology, Zhongshan 
      Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - Department of Anesthesiology, State Key Laboratory of Ophthalmology, Zhongshan 
      Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
FAU - Wang, Yongyi
AU  - Wang Y
AD  - Department of Anesthesiology, State Key Laboratory of Ophthalmology, Zhongshan 
      Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
FAU - Huang, Jingxia
AU  - Huang J
AD  - Department of Anesthesiology, State Key Laboratory of Ophthalmology, Zhongshan 
      Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
FAU - Gan, Xiaoliang
AU  - Gan X
AD  - Department of Anesthesiology, State Key Laboratory of Ophthalmology, Zhongshan 
      Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20230124
PL  - United States
TA  - Ophthalmic Plast Reconstr Surg
JT  - Ophthalmic plastic and reconstructive surgery
JID - 8508431
RN  - I0OU31PUI5 (flurbiprofen axetil)
RN  - L2T84IQI2K (Nalbuphine)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Humans
MH  - *Nalbuphine/therapeutic use
MH  - Ambulatory Surgical Procedures
MH  - Acetaminophen/therapeutic use
MH  - Prospective Studies
MH  - Pain, Postoperative/prevention & control
MH  - *Analgesia
MH  - Double-Blind Method
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2023/02/03 06:00
MHDA- 2023/05/15 06:42
CRDT- 2023/02/02 07:46
PHST- 2023/05/15 06:42 [medline]
PHST- 2023/02/03 06:00 [pubmed]
PHST- 2023/02/02 07:46 [entrez]
AID - 00002341-202305000-00010 [pii]
AID - 10.1097/IOP.0000000000002308 [doi]
PST - ppublish
SO  - Ophthalmic Plast Reconstr Surg. 2023 May-Jun 01;39(3):260-265. doi: 
      10.1097/IOP.0000000000002308. Epub 2023 Jan 24.